关键区别 - 骨髓增生与骨髓增生
不同血细胞的产生发生在骨髓。Stem cellslying within the marrow differentiate into various cell types along a spectrum of cell lineages. This process of differentiation is highly regulated predominantly by the genes. Therefore,突变这些基因可能会混乱整个过程,从而导致无数的血液学疾病,这些血液学疾病将两组广泛归类为骨髓增生性和骨髓增生性。在脊髓增生性疾病中,不同血细胞谱系中细胞的数量有所增加。骨髓发育异常是指干细胞无法成熟红细胞,,,,白血细胞,,,,and血小板。因此,骨髓增生性和骨髓增生性的关键区别在于,在骨髓增生性疾病中,there is an increase in the number of normal cells whereas, in myelodysplastic disorders, there is an increase in the number of abnormal immature cells.
CONTENTS
1。概述和关键差异
2。什么是骨髓增生性
3。什么是骨髓塑料
4。Similarity Between Myeloproliferative and Myelodysplastic
5。Side by Side Comparison – Myeloproliferative vs Myelodysplastic in Tabular Form
6.Summary
什么是骨髓增生性?
在脊髓增生性疾病中,不同血细胞谱系中细胞的数量有所增加。The pathognomic feature of myeloproliferative conditions is the presence of a mutated and constitutively activatedtyrosinekinase gene along with various aberrations in the signaling pathways that lead to growth factor independence.
大多数骨髓增生性疾病源自多能髓样祖细胞,偶尔来自多能干细胞。
这些疾病中观察到的常见病理变化包括,
- 增加骨髓的增殖驱动
- 外载体hematopoiesis
- 骨髓纤维化以及外周血细胞减少症
- 转换为acute leukemia
以下是骨髓增生性疾病的主要品种:
- Chronic myelogenous leukemia
- 多余的Vera
- 基本的thrombocytopenia
- 原发性骨髓纤维化
- 全身性肥大性
- 慢性嗜酸性白血病
- 干细胞白血病
什么是骨髓塑料?
骨髓增生出现是指干细胞无法成熟到红细胞,白细胞和血小板中。Consequently, the hemopoiesis is impaired and there is a higher risk of developing acute myeloid leukemia.
在这些骨髓发育不良的条件下,骨髓中的干细胞被多种能够增殖但以无效方式增殖的多种肿瘤多型干细胞所取代。因此,患者将患有全年。
Myelodysplastic disorders can be due to acquired causes such as exposure to genotoxic radiation or idiopathic causes.
Morphological Changes
有骨髓增生,这与差分差异化有关粒细胞,,,,巨核细胞在某些情况下,也可以观察到肌细胞的增加,也可以观察到肌细胞的增加。
Clinical Features
- 通常,70岁以上的老年人受到这种状况的影响
- Recurrent infections
- Unexplained hemorrhages
- 弱点
骨髓发育障碍分为各种亚组,以评估疾病预后。患者通常在症状发作后的9-29个月内死亡。
Treatments
- Allogeneic hemopoietic stem cell transplantation
- 控制感染的抗生素
- Blood product transfusion
我s the Similarity Between Myeloproliferative and Myelodysplastic?
- Both kinds of disorders are primarily due to the genetic mutations affecting the production of cells within the bone marrow.
骨髓增生性和骨髓增生性有什么区别?
骨髓增生性与骨髓增生性 |
|
在脊髓增生性疾病中,不同血细胞谱系中细胞的数量有所增加。 | 骨髓塑性出现是指干细胞无法成熟成红细胞,白细胞和血小板。 |
Pathognomic Features | |
The pathognomic feature of myeloproliferative conditions is the presence of a mutated and constitutively activated tyrosine kinase gene along with various aberrations in the signaling pathways that lead to growth factor independence. | 在这些骨髓发育不良的条件下,骨髓中的干细胞被各种能够增殖但无效方式增殖的肿瘤多型干细胞所取代。 |
常见的病理变化 | |
|
有骨髓增生,,,,which is associated with disordered differentiation of granulocytes, megakaryocytes, erythroids, etc. In some cases, an increase in the myeloblasts can also be observed. |
摘要 - 骨髓增生与骨髓增生
在脊髓增生性疾病中,不同血细胞谱系中细胞的数量有所增加。骨髓增生出现是指干细胞无法成熟到红细胞,白细胞和血小板中。在骨髓增生性疾病中,正常血细胞的数量有所增加,而在骨髓增生性疾病中,异常未成熟细胞的数量增加。这是骨髓增生性和骨髓增生性的主要区别。
参考:
1. Kumar,Vinay,Stanley Leonard Robbins,Ramzi S. Cotran,Abul K. Abbas和Nelson Fausto。罗宾斯和科特兰疾病的病理基础。第9版。宾夕法尼亚州费城:Elsevier Saunders,2010年。印刷。
图片提供:
1.“骨髓增生性疾病(3953335782)的骨髓中的网状蛋白增加”(CC BY 2.0)通过下议院维基梅迪亚
2。“Megakaryocytes in MDS (RAEB and 5q-chromosome abnormality)” By The Armed Forces Institute of Pathology (AFIP) – PEIR Digital Library (Pathology image database). (Public Domain) via下议院维基梅迪亚
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