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Difference Between NF1 and NF2

December 18, 2017Posted byRanidu

Key Difference – NF1vs NF2

Neurofibromatosis is one of the commonest neurogenetic disorders characterized by the development of numeroustumorsarising from the nervous tissues. There are two forms of neurofibromatosis as NF1 (alias von Recklinghausen’s disease) and NF2.Only the neurofibromas develop in NF1. But different types of nervous tumors including cutaneous neurofibromas, acoustic neuromas, meningiomas, and gliomas develop in NF2. This is thekey differencebetween NF1 and NF2.

CONTENTS

1.Overview and Key Difference
2.What is NF1
3.What is NF2
4.Similarities Between NF1 and NF2
5.Side by Side Comparison – NF1 vs NF2 in Tabular Form
6.Summary

What is NF1?

Neurofibromatosis 1aliasvon Recklinghausen’s diseaseis one of the commonest neurogenetic disorders with a prevalence of 1 in 3000. It is usually due to the inheritance of an autosomal dominantmutantgenebut there are cases due to acquired mutations in the relevant gene too.

NF1 is characterized by numerous neurofibromas arising from theneurilemmal sheathand pigmentation.

Skin neurofibromas are present as subcutaneous, pedunculated lumps that increase in number throughout the life.Plexiform neurofibromasusually develop on the major nerves and proximal nerve roots.

Associated features of the disease include,

  • Learning difficulties
  • Malignant transformation
  • Scoliosis
  • Fibrodysplasia
Difference Between NF1 and NF2

图1:纤维瘤

Management

Surgical removal of the neurofibromas has to be done if the symptoms develop

What is NF2?

Neurofibromatosis 2or NF2 is a rarer disease than NF1. It is also an autosomal dominant disorder where many different types of tumors appear.

  • Cutaneous neurofibromas
  • Acoustic neuromas
  • Meningiomas
  • Gliomas

What is the Similarity Between NF1 and NF2?

  • Both are autosomal dominant diseases characterized by the formation of tumors

NF1和NF2有什么区别?

Neurofibromatosis 1 (NF1) vs Neurofibromatosis 2 (NF2)

Only neurofibromas develop in NF1. Different types of tumors including Cutaneous neurofibromas, acoustic neuromas, meningiomas, and gliomas develop in NF2.

Summary – NF1vs NF2

Neurofibromatosis is a nervous disorder with a genetic predisposition. In NF1 only neurofibromas develop whereas in NF2 different types of tumors including cutaneous neurofibromas, acoustic neuromas, meningiomas and gliomas develop. This is the key difference between NF1 and NF2.

Download the PDF Version of NF1 vs NF2

You can download PDF version of this article and use it for offline purposes as per citation note. Please download PDF version hereDifference Between Nf1 and Nf2

Reference:

1.库马尔,Parveen J., and Michael L. Clark. Kumar & Clark clinical medicine. Edinburgh: W.B. Saunders.

Image Courtesy:

1.”Neurofibroma02’By Klaus D. Peter, Gummersbach, Germany – Own work(CC BY 3.0)viaCommons Wikimedia

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Filed Under:DiseasesTagged With:Compare NF1 and NF2,Neurofibromatosis 1,Neurofibromatosis 2,NF1,NF1 and NF2 Differences,NF1 and NF2 Similarities,NF1 Cause,NF1 Clinical Features,NF1 Symptoms,NF1 Treatment,NF1 vs NF2,NF2,NF2原因,NF2 Clinical Features,NF2 Symptoms,NF2 Treatment,von Recklinghausen’s disease

About the Author:Ranidu

Ranidu is passionate about writing articles on medical topics in general parlance. His experience in communicating with the general public during his medical practice has enabled him to describe facts that a layman has to know about a particular disorder in a concise and understandable manner.

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