Thekey differencebetween colonization and infection is thatcolonization is the process of establishment of the microbe in the body tissues while infection is the process of invading body tissues by the microbe to cause the symptoms of the disease.
The病原icity微生物是一个完整的生化和结构过程,由微生物引起疾病的完整机制定义。例如,细菌的致病性可能与细菌细胞的不同成分(例如胶囊)相关,fimbriae, lipopolysaccharides (LPS) and other cell wall components. We can also associate it with the active secretion of substances that damage the host tissues or protect the bacteria from host defenses. Colonization and infection are two terms in microbial pathogenicity. The first stage of the microbial pathogenicity is colonization. It is known as the correct establishment of the pathogen in the host tissues. On the contrary, infection is the invasion of body tissues by the病原引起疾病。
内容
1.Overview and Key Difference
2.什么是殖民化
3.What is Infection
4.殖民和感染之间的相似之处
5。并排比较 - 与表格形式的定植与感染
6。概括
什么是殖民化?
这是微生物和病原体定植的第一步。这是在宿主入口的右侧门户上正确的病原体的正确建立。病原体通常与与外部环境接触的宿主组织定殖。人类条目的门户是泌尿生殖道,消化道,呼吸道,皮肤和结膜。定居这些区域的通常生物具有组织粘附机制。这些依从性机制具有克服和承受宿主防御表达的恒定压力的能力。可以简单地通过细菌附着在人类的粘膜表面时所显示的粘附机制来简单地解释。
细菌附着eukaryotic表面需要两个因素,即受体和一个ligand. The receptors are usuallycarbohydrates或者peptides残留在真核细胞表面上的残基。细菌配体称为粘附。它通常是细菌细胞表面的大分子成分。粘附与宿主细胞受体相互作用。粘附和宿主细胞受体通常以特定的互补方式相互作用。这种特异性与之间的关系类型相媲美酶和substrate or抗体和抗原. Moreover, some ligands in bacteria are described as, Type 1 fimbriae, Type 4 pili, S-layer, Glycocalyx, capsule, lipopolysaccharide (LPS), teichoic acid and lipoteichoic acid (LTA).
什么是感染?
感染is the invasion of body tissues by infectious agents such as bacteria,病毒, their multiplication and the collective responses by the hosts to particular infectious factors ortoxins. Communicable diseases and transmissible diseases are alternative names for infectious diseases. Hosts like humans can overcome infections by using theirinnate and adaptive immune systems. The innate immune system consists of cells likedendritic cells,中性粒细胞,mast cells和巨噬细胞that can fight infections. Moreover, receptors like TLR’S (Toll-like receptors) in the innate immune system easily recognize the infectious agents. Bactericides likelysosomes酶s are highly important in the innate immune system.
In the case of the adaptive immune system, the antigen presenting cells (APS),B cells和T lymphocytesare collectively inducing antigen-antibody reactions to eliminate the infectious agents from the human body completely. However, the pathogen has varied mechanisms in order to overcome the innate and adaptive immune system of a human. In addition, pathogens have evading mechanisms like preventing from attaching to human macrophages and lysosomes. Also, pathogens producetoxins喜欢endotoxins, enterotoxins,Shiga toxins, cytotoxins, heat-stable toxins, and heat-labile toxins. Some of the well-known bacteria likeSalmonella,E-coli在成功的感染过程中产生毒素。此外,只能通过克服宿主的完整分子免疫机制来成功感染。
What are the Similarities Between Colonization and Infection?
- Colonization and infection are the main steps of the microbial pathogenicity.
- 他们共同努力引起疾病。
- 此外,这两个步骤对于疾病或症状的发生极为重要。
- Both of them are equally important for pathogen multiplication.
What is the Difference Between Colonization and Infection?
Colonization is the process of establishment of the microbe in the body tissues. In contrast, infection is the invasion of body tissues by a pathogen, their multiplication and, the collective responses by the hosts to particular infectious factors or toxins of the pathogen. Adhesins like pili, fimbriae, and LPS are extremely important for colonization while infection does not need adhesions. Moreover, The cell receptors are important in attaching to the pathogen for a successful colonization process; however, the cell receptors are not important for infection.
定植和感染之间的另一个区别是它们的毒素产生。定植不会产生毒素,而感染则不会产生毒素。此外,前者不会引起疾病或症状,而后者则不会引起疾病或症状。定植和感染之间的另一个区别是急性炎症。定植不会引起急性炎症或损害宿主,而感染会导致急性炎症并损害宿主组织。
概括– Colonizationvs感染
细菌病例中的致病性与细菌细胞的不同成分有关,例如胶囊,纤维膜,脂多糖(LPS),Pili和其他细胞壁成分,例如Teichoic Acid,Glycocalyx等。损害宿主组织或保护细菌免受宿主防御的物质。定植和感染是微生物致病性的两个主要步骤。微生物致病性的第一阶段是定殖。它是宿主组织中病原体的正确建立或宿主进入的右门户。相反,感染是病原体引起疾病的侵袭人体组织。这是定殖和感染之间的差异。
下载殖民化与感染的PDF版本
You can download PDF version of this article and use it for offline purposes as per citation note. Please download PDF version hereDifference Between Colonization and Infection
Reference:
1. WI,肯尼斯·托达尔·麦迪逊(Kenneth Todar Madison)。细菌病原体的定殖和侵袭,Available here.
2.“感染”。Wikipedia,Wikimedia基金会,2017年11月18日,Available here.
Image Courtesy:
1.’Pathogenic Infection’By Uhelskie – Own work,(CC BY-SA 4.0)viaCommons Wikimedia
2.’Chain of Infection’ By Julesmcn – By Genieieiop – Own work(CC BY-SA 4.0)viaCommons Wikimedia
发表评论