Key Difference – PeginterferonAlfa 2a vs 2b
在药物领域,针对不同疾病的不同药物开发了不同的药物。它们是通过基于研究的证据开发的,该证据导致该药物在特定疾病状况中非常有效,副作用较少。Peginterferons在市场上以Peginterferon Alfa 2A和Peginterferon Alfa 2b的价格广泛使用。peginterferon alfa 2a用于治疗程序乙型肝炎和Cand Peginterferon Alfa 2B is used for the treatment ofMelanoma还有丙型肝炎,但不是Hepatitis B。这是关键区别在Peginterferon Alfa 2a和2b之间。
CONTENTS
1。概述和关键差异
2。什么是peginterferon alfa 2a
3。什么是peginterferon alfa 2b
4。Similarities Between Peginterferon Alfa 2A and 2B
5.Side by Side Comparison – Peginterferon Alfa 2A vs 2B in Tabular Form
6.Summary
什么是peginterferon alfa 2a?
在用于治疗丙型肝炎和丙型肝炎的不同药物的背景下,peginterferon alfa-2a在其中广泛使用。peginterferon alfa-2a也称为Pegypation Interferon alfa-2a。这属于阿尔法干扰素家族,它是卵形的,以防止药物崩溃。在药品领域,该产品以品牌名称出售Pegasys。Peginterferon alfa-2a is an interferon. In the context ofimmunology,,,,interferons are considered as proteins that are released in response to a viral infection. Interferons act on viruses and thereby prevent the compromising of the immune system.
治疗丙型肝炎,席拉组合py of Peginterferon alfa-2a and ribavirin is practiced. It has been found out that the combination therapy treatment is much more effective rather than providing Peginterferon alfa-2a alone. The use of ribavirin combined therapy during pregnancy is strictly prohibited. But in the disease condition Hepatitis B, Peginterferon alfa-2a is provided alone and not as combination therapy. During the treatment of both Hepatitis B and Hepatitis C, the therapeutic is injected under the skin.
In the United States, Peginterferon alfa-2a was approved for medical use in the year of 2002 by the World Health Organization. Also, this drug is approved worldwide for the treatment of chronic hepatitis C which includes immuno-compromised individuals with艾滋病病毒andcirrhosisas a co-infection. As of most of the drugs, Peginterferon alfa-2a has its set of common side effects. This includes nausea,疲劳,,,,headache,,,,hair loss. The side effects also could be at severe levels which include精神病,感染,血块andautoimmune disorders。
什么是peginterferon alfa 2b?
Peginterferon alfa-2b is utilized in the treatment of Hepatitis C and Melanoma. Similar to Peginterferon alfa-2a, Peginterferon alfa-2b is given as a combined drug with ribavirin during the treatment of Hepatitis C. During the condition of melanoma, it is given as achemotherapeutic手术完成后。在两种治疗方法中,都将药物注射在皮肤下。peginterferon alfa-2b是一种干扰素,属于阿尔法干扰素家族,并在宿主细胞被病毒感染时参与消除过程。
Peginterferon alfa-2b consists of common side effects such as nausea, pain at the site of injection, hair loss and sometimes fever. The side effects may be fatal which results in psychosis, problems in the liver, formation of blood clots and occurrence of irregular heartbeats.
Peginterferon Alfa-2b利用JAK-STAT信号通路作为主要作用机理。通过一系列反应,将进行细胞分化,最终将导致apoptosis;程序性细胞死亡。peginterferon alfa-2b具有抄写几个基因以充当多功能的能力cytokine这是免疫调节的。这种多功能细胞因子涉及许多利用不同细胞的免疫机制,包括诱导T helper cells发展成II型T辅助细胞,以最大化刺激B细胞并增加产量antibodiesagainst the specific抗原这是非自我的。
What are the Similarities Between Peginterferon Alfa 2A and 2B?
- 两种药物均用于治疗丙型肝炎
- 两种药物都有常见的副作用,例如恶心,疲劳和头痛
- Both drugs have common fatal side effects such as psychosis andthrombosis。
What is the Difference Between Peginterferon Alfa 2A and 2B?
Peginterferon Alfa 2A vs Peginterferon Alfa 2B |
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Peginterferon Alfa 2A is an interferon which is utilized in the treatment of Hepatitis B and C. | Peginterferon alfa 2b是一种药物,用于治疗丙型肝炎和黑色素瘤。 |
替代名称 | |
Pegasys, Pegylated Alfa 2A | Pegintron,Pegypated Alfa 2b |
致命的副作用 | |
自身免疫性疾病 | 心跳不规则 |
Summary – PeginterferonAlfa 2a vs 2b
Peginterferon Alfa 2A is used for the treatment of Hepatitis C and Hepatitis B. It is present in under the brand name Pegasys. Peginterferon Alfa 2A is combined with Ribavirin during the treatment of Hepatitis C. But it is provided as a single drug for Hepatitis B. Peginterferon Alfa 2B is utilized during treatment for Hepatitis C and melanoma. Similar to Peginterferon Alfa 2A in hepatitis C treatment, Peginterferon Alfa 2B is used as a combined drug with ribavirin. Both drugs possess common side effects such as fatigue and headache, psychosis and thrombosis.
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参考:
1.Manns,Michael P等。“与干扰素alfa-2b加上利巴韦林相比,Peginterferon Alfa-2b加上利巴韦林,用于初步治疗慢性丙型肝炎:一项随机试验。”柳叶刀,第1卷。358,没有。9286,2001,第958–965页,doi:10.1016/s0140-6736(01)06102-5。
2.Fried,Michael W.等。“ Peginterferon alfa-2a加上利巴韦林,用于慢性丙型肝炎病毒感染。”新英格兰医学杂志,第1卷。347,没有。13,2002,pp。975–982。,doi:10.1056/nejmoa020047。
3.Torriani,Francesca J.等。“ HIV感染患者的慢性丙型肝炎病毒感染的Peginterferon alfa-2a加上利巴韦林。”新英格兰医学杂志,第1卷。351,没有。5,2004,pp。438–450。,doi:10.1056/nejmoa040842。
图片提供:
1。’1215279’by pixabay (Public Domain) via下议院维基梅迪亚
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