Fatty Liver vs Cirrhosis
Fatty liver and cirrhosis are two conditions that affect the liver. They both are common conditions, and both are often detected in alcoholics. Alcohol may or may not be the cause for both conditions; diet can cause fatty liver while NASH is a non-alcoholic type of cirrhosis. Many think that these disorders are specific to alcohol consumption, but the reality is while almost all people with fatty liver and cirrhosis have got it because of excessive alcohol consumption, there are other causes for fatty liver and cirrhosis.
Fatty Liver
脂肪肝脏是一种普遍的疾病,许多年轻人也拥有它。虽然酒精是脂肪肝脏的已知危险因素,但富含脂肪的不健康饮食是通常的罪魁祸首。我们食用的脂肪食品被脂肪酶分解了,在进入系统循环之前,产生的脂肪酸和甘油在肝脏进入肝脏。在肝脏中,许多脂肪酸和甘油被吸收到肝细胞中。它们在那里被存储在肝细胞的细胞质中。由于胶束可溶于水,细胞可以包含的脂肪量有一个限制。多余的沉积物作为脂肪球。这是脂肪肝的病理生理学。
Metabolic disorders like diabetes increases the chance of getting fatty liver. Diabetes is due to inability to absorb and utilize sugar in the blood stream. This triggers a starvation reaction and fat stores in peripheral adipose tissue gets broken down and transported to the liver. This results in an excess of fats in liver cells. There may be a transient increase in liver enzymes, but most are biochemically normal. Fatty liver is a risk factor for cirrhosis. It also bodes poor prognosis in conditions that affect the liver cells like dengue.
Cirrhosis
肝硬化是肝脏结构的不可逆转改变。Long term consumption of an excessive amount of alcohol, hepatitis B, hepatitis C, autoimmune diseases, drugs (methotrexate, methyldopa and amiodarone), genetic disorders (alfa antitrypsin deficiency, Wilson’s disease and hemochromatosis) and Budd-Chiari syndrome are a few causes of cirrhosis.
Cirrhosis may be asymptomatic early-on. When the disease progresses features of liver failure may manifest themselves. White nails, white proximal half and red distal half of nails, enlargement of distal phalanx of fingers like a club, yellowish discoloration of eyes and skin, parotid gland swelling, male breast enlargement, red palms, hand contractures (Dupuytren’s), bilateral ankle swelling, small testes (testicular atrophy) and liver enlargement (in early disease) are the common clinical features of hepatic cirrhosis. Delayed blood clotting (because liver produces most of the clotting factors), encephalopathy (due to impaired ammonia metabolism and neurotransmitter synthesis), low blood sugar (due to poor glycogen breakdown and storage in liver), spontaneous bacterial peritonitis and portal hypertension are a few complications is chronic liver disease.
全血数(贫血,感染,血小板计数),血液尿素,血清肌酐(肝肾脏综合征),包括伽马GT在内的肝酶(酒精中毒高),直接和间接胆红素(Jaundice),血清白蛋白(低IN IN IN IN IN IN IN含量低)肝功能较差),出血时间,凝血时间(肝功能较差),肝炎病毒学,自身抗体,阿尔法胎儿蛋白,开胃蛋白脂蛋白,阿尔法抗胰蛋白酶和腹部的超声扫描是常规研究。
Daily weight, heart rate, blood pressure and urine output monitoring, serum electrolytes, abdominal girth, temperature chart, examining for pleural effusion, tender abdomen due to peritonitis, and low salt and low protein diet are recommended. Antibiotics flush out ammonia forming gut bacteria in case of liver failure. Diuretic remove excess fluid. Ascitic tap removes excessive fluid in the peritoneal cavity. Interferones, ribavirin, and penicillamine have their roles according to the clinical presentation.
What is the difference between Fatty Liver and Cirrhosis?
•脂肪肝比肝硬化更常见。
• Fatty liver is a risk factor for cirrhosis while the reverse is not true.
•脂肪肝是可逆的疾病,而肝硬化则不是。
• Fatty liver does not interfere with liver function while cirrhosis does.
• Fatty liver does not alter liver architecture while cirrhosis does.
•即使在晚期疾病中,脂肪肝也不会导致急性症状。
• Fatty liver does not cause liver failure while cirrhosis does.
• Fatty liver may be cured completely with diet and anti-lipid agents while cirrhosis can only be managed.
• Cirrhosis may necessitate liver transplant while fatty liver never does.
Alice Xsays
Thank you!
Lisa Johnsonsays
A big thank you for the information