Difference Between Mode of Action and Mechanism of Action

Key Difference – Mode of Action vs Mechanism of Action

When a substance enters a living cell, it brings about physical, chemical, structural and functional changes by interacting with the host’s代谢和生化途径。这些相互作用可以诱导细胞的正常作用或抑制细胞的作用。期间药品discovery and administration, it is of great importance to identify the effect caused by the drug to the host system and how the effect is caused by bio chemical interactions, which is more appropriately termed as the Pharmacokinetics of the drug. The terms, Mode of action and Mechanism of Action describe the above two scenarios.生物分子的作用方式进入人体refers to the mode in which the action is brought about and is characterized by the changes that take place in terms of physiological aspects. Mechanism of action refers to the process by which a substance undergoes bio chemical changes within the host in order to bring about the specific action of the administered substance.这是作用方式和作用机理之间的关键区别。

内容

1.Overview and Key Difference
2.What is Mode of Action
3.什么是行动机理
4。作用方式和作用机理之间的相似之处
5。并排比较 - 行动方式与表格形式的作用机理
6。概括

什么是行动方式？

药物等物质的作用方式抗生素or a农药或杂草剂是指该特定物质对宿主细胞的作用引起的物理，解剖或功能变化。这种变化在细胞水平上描述，但结果可能是宏观的。抗生素的模式，例如青霉素, which is isolated from青霉notatum，is the destruction of thebacterial cell通过防止交叉链路形成墙肽聚糖layers. This will result in further destruction of the particular pathogenic bacteria. Thus, the mode of action is important in characterizing substances into groups based upon its resulting actions. For example, all antibiotics that inhibit cell wall synthesis in pathogenic bacteria are classified as cell wall degrading antibiotics and Penicillin, ampicillin and β – lactam containing antibiotics are classified under this category.

什么是行动机制？

The mechanism of action of any biomolecule entering the host system describes the series of bio chemical reactions they undergo in the host cell which results in their mode of action. Biochemical alterations that take place after the administration of a biomolecule is specific and take place under controlled conditions. They can be an酶resulting in forming an enzyme – substrate complex or a ligand binding with its receptor via weak interactions or an antibody binding with itsantigen。The changes brought about by interfering the host cell metabolism is also known as the Pharmacokinetics of a drug or any other chemical entering the cell. The mechanism of action of a drug/antibiotic or any other chemical is highly specific. Thus, when administering correct doses, drugs that are determined upon prolonged research on the particular molecule should be administered. The specific substance should be targeted for a specific cell or organ in the host where that substance will interact with the host mechanism either to upregulate or downregulate the action.

The mechanism of action of Penicillin can be described as follows;

The β lactam ring of penicillin irreversibly binds with the active sites of transpeptidase and acylates by preventing the formation of cross links. When cross link formation is prevented, the cell wall formation in bacteria is prevented. Thus, a specific inhibitor enzyme reaction takes place via specific irreversible binding.

What are the Similarities Between Mode of Action and Mechanism of Action?

• Both actions take place following the administration of a foreign biomolecule into a host cell.
• 两种动作在药物设计和代谢中都很重要。

作用方式和作用机理有什么区别？

行动方式vs Mechanism of Action
生物分子的作用方式是指引起动作的模式，并以细胞中发生的变化为特征。	作用机理是指该物质在宿主内发生生物化学变化的过程，以实现施用物质的特定作用。
结果
由于作用方式，细胞中发生了生理，化学和功能变化。	As a result of the mechanism of action, an alteration of a bio-chemical reaction occurs.
Importance
作用方式对于根据其最终作用来表征不同化合物很重要。	作用机理对于设计药物，阐明特定药物的剂量并评估其对施用的影响很重要。

摘要 - 作用方式与动作机理

药物或抗生素的作用方式和作用机理在生物化学方面具有狭窄的差异，因为这两者都指在给宿主细胞的外源分子施用后发生的变化。这两个概念在药理学中进行了广泛研究，并且是开发用于疾病靶标和致病微生物的新药物的当前趋势。生物分子的作用方式是指引起动作的模式，并以细胞中发生的变化为特征。作用机理是指该物质在宿主内发生生物化学变化的过程，以实现施用物质的特定作用。这是作用方式和作用机理之间的区别。

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参考：

1. Cushnie，T P等。“细菌细胞的形态和超微结构变化是抗菌作用机理的指标。”细胞和分子生命科学：CMLS。，美国国家医学图书馆，2016年12月。Available here。2017年8月17日访问。
2.“自然新闻。”自然新闻，自然出版集团。Available here。2017年8月17日访问。
3. Yocum, R R, et al. “The mechanism of action of penicillin. Penicillin acylates the active site of Bacillus Stear thermophilous D-Alanine carboxypeptidase.” The Journal of biological chemistry., U.S. National Library of Medicine, 10 May 1980.Available here。2017年8月17日访问。

Image Courtesy:

1. Ajereen的“ EMA401行动机制” - 自己的工作（CC BY-SA 3.0）viaCommons Wikimedia