这关键区别between H1 and H2 receptors is that theH1 receptor couples with Gq/11 stimulating phospholipase C while the H2 receptor interacts with Gs to activate adenylyl cyclase.
Histamine is an organic nitrogenous compound that involves local immune responses. Furthermore, it works as a neurotransmitter in the中枢神经系统and the uterus. It participates in inflammatory responses and works as a mediator of itching.嗜碱性粒细胞和肥大细胞产生组胺,组胺增加毛细血管对白细胞和必要的蛋白质的渗透性,以对抗感染剂。为了执行组胺的作用,应约束G蛋白-coupled histamine receptors. There are four types of histamine receptors namely H1, H2, H3, and H4. H1 and H2 are present in associative with the central nervous system and periphery. Hence, the difference between H1 and H2 receptors mainly lies with their mechanism of action.
CONTENTS
1。概述和关键差异
2。What are H1 Receptors
3。什么是H2受体
4。H1和H2受体之间的相似性
5。Side by Side Comparison – H1 vs H2 Receptors in Tabular Form
6。Summary
什么是H1受体?
组胺H1受体或H1受体是四个组胺结合受体之一,它是G蛋白偶联受体。这是涉及在过敏反应过程中产生症状的主要受体。它是一种蛋白质,也是七型跨膜分子。因此,它能够通过G蛋白偶联反应将信号从外部环境转移到细胞内第二使者。
此外,在身体的周围,尤其是在平滑肌中,可以观察到H1受体的广泛分布。除外围外,H1受体还居住在肾上腺髓质,血管内皮,心脏和中枢神经系统等。H1受体结合介导的功能是平滑肌肉的收缩,毛细管渗透性的增加,介导了CNS中的神经频率,CNS,CNS,CNS,CNS,CNS,CNS,CNS,CNS,,CNS,CNS,CNS,CNS,CNS渗透。等等
什么是H2受体?
H2受体是另一种组胺结合受体,它是GS蛋白偶联受体。当这种受体刺激的腺苷环酶激活时,它会增加细胞内浓度营在许多组织中。在中枢神经系统中,尤其是在大脑中,可以看到H2受体的广泛分布。受体浓度在基底神经节,海马,杏仁核和大脑皮层中很高。
Hypothalamus and cerebellum have a low concentration of H2 receptors. Furthermore, H2 receptors present in the parietal cells located in the stomach. It is responsible for regulating the gastric acid level. And also H2 receptors can be seen in the heart, uterus and vascular smooth muscle cells. When the binding of histamine to H2 receptors blocks, it can reduce the amount of acid produced by the stomach. Hence, H2 receptor agonists are popular H2 blockers which use to treat duodenal ulcers, gastric ulcers, Zollinger -Ellison disease etc.
H1和H2受体之间有什么相似之处?
- H1和H2受体是G蛋白偶联受体。
- 组胺与这两个受体结合。
- 这y are proteins.
- 而且,两个受体都位于身体的各个部位。
- 主要是,它们被广泛分布在哺乳动物的大脑中。
- 此外,两者都介导组胺作用。
H1和H2受体之间的区别是什么?
H1和H2受体是两种类型的组胺结合受体,用于发挥组胺作用。H1和H2受体之间的差异主要在于每个受体的机制。H1受体夫妇与GQ/11刺激磷脂酶C,而H2受体与GS相互作用以激活腺苷酸环化酶。H1和H2受体之间的另一个区别是,H1受体主要负责内部时钟,而H2受体则负责调节胃酸水平。
以下信息图显示了表格形式的H1和H2受体之间的差异。
Summary – H1 vs H2 Receptors
H1和H2受体都是类似Rhopopsin的G蛋白偶联受体。它们介导组胺在过敏反应和许多其他生理反应中的作用。组胺与其中的四个组胺受体结合,其中H1和H2主要存在于中枢神经系统中。因此,H1受体夫妻伴有刺激磷脂酶C的GQ/11,而H2受体与GS相互作用以激活腺苷酸环化酶。此外,H1受体主要涉及睡眠效果周期的调节,而H2受体主要涉及刺激顶叶细胞以分泌胃酸。这是H1和H2受体之间的差异。
参考:
1.“组胺H2受体。”。神经图像,学术出版社。在这里可用
2。EMBL-EBI, InterPro. “InterPro.” The European Bioinformatics Institute < EMBL-EBI.在这里可用
图片提供:
1。”H1 Receptor with Doxepin”By Nakane, Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han, Takuya Kobayashi, Raymond C. Stevens & So Iwata (July 2011). “Structure of the human histamine H1 receptor complex with doxepin”. Nature 475 (7354): 65–70. DOI:10.1038/nature10236. PMID 21697825., (Public Domain) via下议院维基梅迪亚
2.“胃酸分泌的决定因素” Adam L. Vanwert,Pharm.D。,博士学位。- 自己的工作,(公共领域)通过下议院维基梅迪亚
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