蛋白酶和肽酶之间的差异|比较类似术语之间的差异

关键区别 - 蛋白酶与肽酶

蛋白质是大分子。它们主要由碳，氢，氧和氮组成。由于其在身体的结构和功能方面的作用，这是一种重要的营养。蛋白质消化或蛋白水解始于胃，尽管大量蛋白质消化发生在小肠使用胰腺酶。蛋白质消化的最终产物是氨基酸，，，，which are readily absorbed in the small intestine and transported via the blood to target organs. Protein degradation is also a common procedure practiced under an industrial environment. Protein degradation is mainly done in industries such as leather, wool, and food industry. Protein degradation is an enzyme-catalyzed reaction. Hence, at present, these enzymes are produced worldwide usingrecombinant DNA technology。两种蛋白水解酶蛋白酶和肽酶在自然现象和工业尺度中都参与蛋白质降解。蛋白酶s are a type of hydrolases, which are involved in the cleavage of the肽键在蛋白质中，肽酶是一种能够裂解肽链末端的蛋白酶。This is the key difference between Protease and Peptidase.

1。概述和关键差异
2。什么是蛋白酶
3。什么是肽酶
4。蛋白酶和肽酶之间的相似性
5。并排比较 - 表格形式的蛋白酶与肽酶
6.Summary

什么是蛋白酶?

蛋白酶是一种水解酶，属于酶委员会3类（EC3）的类别。蛋白酶参与激活亲核试剂这将攻击肽键的碳。这种亲核攻击之后是高能中间体的形成。为了稳定这种中间体，不稳定的复合物将被降解以达到稳定性。这种降解将导致肽键的切割，导致两个肽的片段。基于这种催化机制，蛋白酶有四种主要类型：天冬氨酸，半胱氨酸蛋白酶，天冬氨酸蛋白酶和金属蛋白酶。每个酶类别的亲核攻击方法略有不同。

蛋白酶s are used in two main contexts: under natural conditions in protein digestion and degradation, under industrial conditions to produce commercial products.

在生理学的背景下，蛋白酶对于食物蛋白的消化，蛋白质更新，细胞分裂，流血级联反应，信号转导，处理，加工是必不可少的多肽激素，凋亡和几种引起疾病的生物的生命周期，包括复制逆转录病毒。

图01：蛋白酶

皮革工业应用的蛋白酶anufacturing, wool manufacturing, production of Klenow fragments, peptide synthesis, digestion of unwanted proteins during nucleic acid purification, use of proteases in cell culture experiments and tissue dissociation, preparation of recombinant antibody fragments for research, diagnostics, and therapy.

根据对肽链接的攻击部位，将蛋白酶进一步分为雌激酶和内肽酶。

什么是肽酶？

肽酶是一种蛋白酶。肽酶的作用机理类似于蛋白酶。肽酶的特征是雌激酶，并参与裂解末端肽键。末端肽连接可以是羧基端子末端或氨基端子末端。

图02：肽酶动作

Similar to proteases, peptidases also have two main applications. They are in physiology and in industrial applications.

What are the Similarities Between Protease and Peptidase?

Both are proteolytic enzymes.
两者都是水解酶。
Both enzymes can be produced via recombinant DNA technology.
两种酶都参与裂解蛋白质和降解蛋白质的肽键。
Both have applications in industry – leather industry, wool industry, food industry and recombinant DNA technology and proteomics.
在生理学中，蛋白酶和肽酶用于消化过程。

蛋白酶和肽酶有什么区别？

蛋白酶vs Peptidase
蛋白酶是裂解蛋白质中肽键的酶。	肽酶是一种能够裂解肽链末端的蛋白酶。
Action
蛋白酶can be endopeptidases or exopeptidases.	肽酶是肽酶。

Summary – Protease vs Peptidase

蛋白酶s and peptidases are proteolytic enzymes which have a variety of functional roles in physiology. The basic difference between proteases and peptidases is that protease can be endopeptidases or exopeptidases whereas peptidases are exopeptidases. At present, these enzymes are produced via recombinant DNA technology as it will result in a high yield and high-quality end products which are cost effective.

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References:

1。Mótyán, JánosAndrás, et al. “Research Applications of Proteolytic Enzymes in Molecular Biology.” Biomolecules, MDPI, Dec. 2013,在这里可用。2017年9月15日访问。
2.“结构生物化学/酶催化机制/蛋白酶。”结构生物化学/酶催化机制/蛋白酶 - Wikibooks，开放世界的开放书籍，在这里可用。2017年9月15日访问。