Difference Between Interferon Beta-1A and 1B

关键差异 -干扰素beta-1a vs 1b

在现代药物的背景下，使用不同的技术合成各种类型的药物，以便针对不同的疾病疾病开发有效的治疗剂。治疗multiple sclerosis这是一种脱髓鞘疾病，干扰素β-1A和干扰素β-1B被广泛使用。两种治疗剂都不是治愈疾病相反，它们有效地减少了疾病状况的进展。干扰素β-1Ais utilized during the early stage of the disease condition for effectiveresults,在疾病疾病的第二进行阶段，使用干扰素β-1B。这是关键区别在干扰素β-1A和干扰素β-1B之间。

内容

1.概述和关键差异
2.What is Interferon Beta-1A
3.What is Interferon Beta-1B
4。干扰素β-1A和1B之间的相似之处
5。并排比较 - 干扰素β-1A与1B的表格形式
6。概括

What is Interferon Beta-1A?

在多发性硬化症的治疗中，使用干扰素β1A。多发性硬化症是一种疾病，发生在神经系统。神经细胞被称为覆盖髓鞘。髓鞘由Schwann细胞which increase the speed of transmission of nerve impulses. Multiple sclerosis is a demyelinating disease which disrupts the myelin tissue. Multiple sclerosis causes different physical andmental disorders。

干扰素β1A是一种属于干扰素家族的药物。它是一个细胞因子并由哺乳动物细胞产生。干扰素β1A不是可以治愈多发性硬化症疾病状况的药物。如果在早期发现疾病状况，该药物将有效地起作用，以减慢疾病状况的快速发展。干扰素β1A以可注射形式施用。注射后，注射皮肤面积极易受到皮肤反应的发展，包括皮肤坏死。

皮肤reacti的发生ons is more prevalent in females within the first month of treatment. If the skin reactions are at mild conditions, the drug is provided continuously. But if conditions like cutaneous necrosis occur, the treatment procedures are discontinued. With time, due to the destruction of fat tissue, the site of injection could be dented. This is a rare condition during the treatment of Interferon Beta 1A. In order to prevent the occurrence of infections at the site of injection, the site of injection is rotated in patients and aseptic techniques are utilized.

The drug Interferon Beta 1A involves in balancing the pro-inflammatory and anti-inflammatory agents present in the brain. Also, it acts to reduce the number of inflammatory cells that cross the blood-brain barrier. Interferon Beta 1A treatment cause the reduction of inflammation of neurons and improves the survival rate of neurons by the increment of production of the nerve growth factor.

What is Interferon Beta-1B?

干扰素Beta-1B is another type of cytokine which belongs to the family, interferons. This is synthesized in modified大肠杆菌。该药物在多发性硬化症的第二阶段的治疗过程中有效使用。多发性硬化症的第一阶段用干扰素β-1A治疗，发现同一药物对于疾病的第二阶段无效。因此，干扰素β-1B被用作多发性硬化症第二进行性阶段的治疗性。该药物无法治愈该疾病，而是会减少疾病的快速发展。

Unlike Interferon Beta-1A, the effects of Interferon Beta-1B are still under investigation. The drug is administered as a subcutaneous injection. The drug is only available in the form of injection. Since it is provided to the subcutaneous layer of the skin, the site of injection is highly susceptible to the occurrence of infections. This is more prevalent in females than males. The occurrence of skin infections directly affects the treatment procedures. If the infections are at mild conditions, the drug is administered continuously. But if conditions like cutaneous necrosis occur the provision of the drug is discontinued. The occurrence of infections could be minimized with the practice ofaseptic技术。

Similar to Interferon Beta-1A, Interferon Beta-1B involves in balancing the pro-inflammatory and anti-inflammatory agents present in the brain. The therapeutic involves the reduction of neuron inflammation and prevents the excess transfer of inflammatory cells across the blood-brain barrier. The neuronal survival is uplifted by Interferon Beta-1B by the production of nerve growth factor.

干扰素β-1A和1B之间有什么相似之处？

• 干扰素β-1A和1B具有相同的副作用，例如皮肤感染，可能导致皮肤坏死。
• 两种药物都无法治愈，但在一定程度上降低了疾病的进展。
• 两种药物都平衡了大脑中存在的促炎和抗炎药。
• Both drugs prevent the excess transfer of inflammatory cells across the blood-brain
• 两种药物都通过产生神经生长因子来提高神经元存活率。

干扰素β-1A和1B有什么区别？

干扰素β-1A与干扰素β-1B
干扰素β–1a是一种在疾病病的早期阶段使用的药物，以获得有效结果。	干扰素Beta – 1B is another type of cytokine which belongs to the family, interferons.
有效条件
干扰素β–1a在多发性硬化症的一级阶段用作有效的治疗性。	干扰素β - 1B有效地用于治疗该疾病的第二进行性阶段。
Synthesis
In mammalian cells.	在修改中大肠杆菌。

总结——干扰素beta-1a vs 1b

干扰素β-1Aand Interferon Beta-1B are two types of therapeutics which are used during the treatment of multiple. Both drugs don’t act as a cure for the disease but effectively reduce the progression of the disease. Interferon Beta-1A is provided during initial stages of the disease whilst Interferon Beta-1B is provided during the second progressive stage. Both the therapeutics possesses similar side effects which are skin infections. The infections could lead to fatal levels such as cutaneous necrosis. Both drugs prevent the excess transfer of inflammatory cells across the blood-brain barrier and increase the rate of neuronal survival by the production of nerve growth factor. This can be identified as the difference between Interferon Beta-1A and Interferon Beta-1B.

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You can download PDF version of this article and use it for offline purposes as per citation note. Please download PDF version hereDifference Between Interferon Beta-1A and 1B

Reference:

1.Jacobs，Lawrence D.等。“肌内干扰素β -1A用于复发多发性硬化症的疾病进展。”Wiley Comprions，Wiley Company，Wiley订阅服务Annals of Neurology，2004年10月8日。Available here
2.“Interferon beta-1b.” The Lancet, Elsevier, 22 Sept. 2003.Available here

Image Courtesy:

1.’1AU1人干扰素-Beta01'由Nevit Dilmen（CC BY-SA 3.0）via下议院维基梅迪亚