Difference Between Gangrene and Necrosis

Gangrene vs Necrosis

Necrosis and gangrene are two terms encountered in pathology. Although these are not terms usually heard among non-medical people, it is helpful to understand the basic differences especially if these happen to you or your loved ones. After extensive tissue injury, the doctors may use these terms when they explain things to you. They are very difficult to explain in a few simple terms because they are complex processes with multiple important stages. Therefore, medical professionals use the terms necrosis and gangrene to refer to the whole process. The first thing to get into our heads is that there are various types of necrosis and gangrene is one such type. The difference between necrosis and gangrene is, therefore, subtle.

Necrosis

Necrosis may occur directly or after cell degeneration. Early changes are very subtle and appear on electron microscope only after 2 to 3 hours and in the light microscope only after 6 hours. Cellular changes can be divided into nuclear changes and cytoplasmic changes. Nuclear material may first clump into dense masses, which stain with basic stains. This is known as “Pyknosis”. Afterwards, these clumps may break up into small particles in a process known as “Karyorrhexis”, or get lysed in a process called “Karyolysis”. Cytoplasmic changes start with thecytoplasmbecominghomogenousand stain deeply with acidic stains. This is due to denaturation of cytoplasmic proteins. Specialorganellesabsorb water and swell.Enzymesget released fromlysosomes,细胞分解（自溶）。从生化上，所有这些变化都与大量钙离子涌入。坏死有多种类型。它们是凝血性坏死，液化坏死，脂肪坏死，案例坏死，胶质性坏死，纤维蛋白不同的坏死和坏死。

在coagulative necrosis细胞将细胞轮廓保留几天，而所有其他变化发生。这种类型的坏死通常在血液供应不足后最常见的固体器官中看到。在liquefactive necrosisthe cell is lysed completely; thus there is no cellular outline. This is commonly seen in the brain and spinal cord. There are two types of fat necrosis; enzymatic and non-enzymatic fat necrosis. Inenzymatic fat necrosiswhich occurs characteristically inacutepancreatitis，细胞脂肪被裂解成脂肪酸，并且glycerolby pancreatic lipase and the result forms complexes with calcium. Thus, the appearance is chalky white.Non-enzymatic fat necrosisis mostly seen in subcutaneous tissue, breast and abdomen. Patients with non-enzymatic fat necrosis almost always give a history of trauma. However, trauma is not clearly identified as the definitive cause. Fibrosis closely follows non-enzymatic fat necrosis forming a solid mass sometimes indistinguishable from a cancer clinically.Caseous and gummatous necrosisare due to granuloma formation after infections.Fibrinoid necrosisis commonly seen in autoimmune diseases.

Gangrene

坏疽是一个广泛使用的术语，指的是临床状况，在临床状态下，由于次要因次要而异。bacterial infection. There are three types of gangrene; dry, wet and gas gangrene.Dry gangrenemostly occurs at extremities due to poor blood supply resulting from blockage ofarteries.Wet gangrene严重的细菌感染叠加在坏死上。它可以在四肢和内部器官中发生。湿的坏疽很难从相邻的健康组织中划分。因此，手术切除很困难。Mortality ratein wet gangrene is high.Gas gangreneis due to Clostridium perfringens infection. It is characterized by extensive necrosis and production of gas. There is crepitation on palpation.

坏死和Gangre之间的区别是什么ne?

• Necrosis can occur without infection while gangrene is due to infection of necrotic tissue.

• Gangrene is usually extensive than other types of necrosis.

• Mortality in gangrene is higher than in other types of necrosis.

Read more:

1.Difference Between Necrosis and Apoptosis