What is the Difference Between CMV IgG and IgM

Thekey differencebetween CMV IgG and IgMis that CMV IgG is a type of CMVantibodythat indicates a person was infected with CMV at some time during their life, while CMV IgM is a type of CMV antibody that indicates a primaryinfectionin combination with the presence ofIgg.

Cytomegalovirus (CMV) is a commonherpes virus这会感染人类，但通常是无害的。当您一次感染一次时，该病毒在整个生命周期中一直保持体内。CMV的传播通过血液，唾液，尿液，精液和母乳等体液进行。健康的人没有表现出症状或疾病。在其他人中，症状可能包括发烧，疲劳，肌肉酸痛，喉咙痛和腺体肿胀。CMV感染是怀孕期间的关注点，因为它可以传递给婴儿。此外，CMV是对免疫功能低下的人的关注，尤其是那些接受器官，干细胞或骨髓移植或具有艾滋病的人。轻度的CMV感染通常不会治疗。但是，如果出现症状，可以服用抗病毒药物。为了诊断CMV感染，可以进行血清学检查（抗体测试），并检测血液中的CMV抗体。 CMV IgM and CMV IgG are two types of CMV antibodies produced in response to a CMV infection.

内容

1.Overview and Key Difference
2.What is CMV IgG
3.What is CMV IgM
4.Similarities – CMV IgG and IgM
5.CMV IgG与表格形式的IgM
6.Summary – CMV IgG vs IgM

What is CMV IgG?

CMV IgG is one of the two types of CMV antibodies. CMV IgG appears after 1 to 2 weeks of IgM antibody detection. It shows a peak at 2 to 3 months post-infection. Then it remains detectable throughout the lifetime.

Generally, IgG levels go up during the active infection. Then it starts to stabilize as CMV infection resolves and the virus becomes inactive. A 4-fold increase in IgG between the first and second samples confirm an active infection. After a primary infection, a certain level of IgG (measurable amount) remains in our body for a lifetime in order to protect us from reinfection.

What is CMV IgM?

巨细胞病毒IgM抗体出现在first 1 to 2 weeks after primary infection of CMV. Therefore, this type of antibody is produced as a first response to CMV infection. However, it is not always an indication of primary infection. It can be detected during the secondary infection as well. But positive CMV IgM tells us an indication of a recent infection. In most individuals, IgM level gradually decreases and becomes undetectable by 4 months after infection.

In some people, it may remain detectable until a year. When CMV reactivates in the body after a certain period of time, IgM reappears and comes to a detectable level. Hence, it is evident that the presence of IgM does not always indicate a primary infection.

CMV IgG和IgM之间有什么相似之处？

• CMV IgG and IgM are two types of antibodies produced by our body in response to CMV infection.
• They are used to diagnose the infection.
• 在血清学测试期间，检测到同一样品中两种抗体的存在或不存在。

What is the Difference Between CMV IgG and IgM?

CMV IgG is an antibody produced by our body after several weeks of CMV primary infection while CMV IgM is an antibody produced by our body as the first response to the primary infection of CMV. So, this is the key difference between CMV IgG and IgM. Moreover, the presence of CMV IgG indicates that a person was infected with CMV at some time during their life, while the presence of CMV IgM together with IgG indicates the primary infection of CMV. Thus, this is another main difference between CMV IgG and IgM. Furthermore, IgG remains for the life while IgM gradually decreases and becomes undetectable after 4 months of post-infection.

The following infographic lists the differences between CMV IgG and IgM in tabular form for side by side comparison.

Summary – CMV IgG vs IgM

CMV IgG and IgM are two types of antibodies produced in our body against CMV. CMV IgM is produced as a first response to this infection. Therefore, IgM appears within the first 1 to 2 weeks after primary (new) infection. CMV IgG is produced several weeks after the primary infection. IgG levels go up during the active infection and then declines with the viral inactivation. However, a measurable amount of IgG remains throughout the lifetime in order to provide protection against CMV reinfections. The presence or absence of both types of antibodies is measured during a serological test. Thus, this is the summary of the difference between CMV IgG and IgM.

Reference:

1.“”巨细胞病毒（CMV）：症状，原因，治疗和预防。”WebMD.
2. “Cytomegalovirus (CMV) Tests。”在线实验室测试，2021年3月24日。

Image Courtesy:

1.“”Cytomegalovirus 01”从恩维基百科转移到下议院。来自疾病控制与预防中心的公共卫生图像图书馆（PHIL）（公共领域）通过Commons Wikimedia
2. “IGM方案” Artur JanFijałkowski(CC BY-SA 2.5)via Commons Wikimedia