D二聚体和FDP之间的差异

关键区别 - DDimer vsFDP

Fibrinogenis one of the main components involved inblood clotting process. Fibrinogen is the protein in which thefibrinnetwork is formed upon injury to tissue. This process is known as blood clotting. Fibrinolysis is the process where the fibrin is broken down by the action of plasmin. These degradation products are known as Fibrin Degradation Products (FDPs). Fibrin Degradation Product or FDP is a product of fibrinolysis that remains after the clot has been dissolved. D Dimer is the final product of fibrin degradation and is a type of FDP. Thekey differencebetween FDP and D Dimer is the structure.FDP do not contain extra linkages of D and E subunits of Fibrin, whereas D dimer is composed of extra linkages.

内容

1.Overview and Key Difference
2.什么是D二聚体
3.什么是FDP
4.Similarities Between D Dimer and FDP
5.Side by Side Comparison – D Dimer vs FDP in Tabular Form
6.概括

什么是D二聚体?

D Dimer is the final end product of fibrinolysis. It is the type of a Fibrin Degradation Product. It has a molecular weight of 180 kDa and is composed of extra linkages with D and E subunits of fibrin. Thus, D dimer is composed of remnants of all three chains of fibrinogen that are termed as; alpha, beta and gamma. These chains are cross-linked with disulfide bonds. D Dimer attains a dimeric structure as the name suggests. The dimeric structure of D dimer is held by isopeptide bonds between the gamma chains. They are intermolecularcovalent bonds.

The D dimer test is a test done to the analysis of cardiac health andatherosclerosis. D dimer levels of healthy individuals lie below 0.5 µg/ml whereas, elevated levels suggest thrombosis, pulmonary embolism and atherosclerosis. Monoclonal antibodies are used in the D dimer test to precisely identify the levels of antibodies. This test is much error prone due to the existence of many FDPs similar to D dimer.

什么是FDP？

Fibrin Degradation Product or FDP is the remnant of fibrinolysis, and is the process in which a blood clot is dissolved or disintegrated. FDPs remain in the bloodstream upon fibrinolysis. Upon tissue injury, the血液凝血因子，血小板and other cofactors combine together to form a fine network of fibrin that will act as a net over the injury until it is healed. Once the tissue healing process is completed, the blood clot is broken down and dissolved by an enzymatic process that utilizes Plasmin. The cross-linked fibrin network is disintegrated to produce FDPs.

自民党测试对心脏的健康做了分析and atherosclerosis. Similar to D dimer test, elevated levels of FDP will suggest thrombosis, atherosclerosis and pulmonary embolism.

D二聚体和FDP之间有什么相似之处？

• Both D Dimer and EDP are degradation products of fibrinolysis
• 分析D二聚体和EDP分子的血栓形成，动脉粥样硬化和肺栓塞。
• Both tests involving FDP and D dimer are done as coagulation tests.
• Plasmin is involved in the degradation of fibrin, to yield both FDP and D dimer.

D二聚体和FDP有什么区别？

D Dimer vs FDP
D Dimer is the final product of fibrin degradation and is a type of FDP.	Fibrin Degradation Product or FDP is a product of fibrinolysis that remains after the clot has been dissolved.
Structure
D Dimer is a dimeric structure.	EDP can be a simple mesh-like structure.

概括– DDimer vsFDP

D二聚体和FDP是纤维蛋白溶解的降解产物，而最终二聚体最终产物是D二聚体。纤维蛋白溶解或纤维蛋白网络的降解是作为凝结过程的后事件发生的。纤溶酶参与将产生FDP和D二聚体的降解过程。这两个组件都用作实验室测试标本，以分析动脉粥样硬化的风险。这是D二聚体和FDP之间的差异。

Reference:

1.“纤维蛋白降解产物（FDP）：这是什么？”Healthline，Healthline Media。Available here
2.“What Is the D-Dimer Test?” WebMD, WebMD.Available here

Image Courtesy:

1.’D-Dimère’By Pocout – Own work,(CC BY-SA 3.0)viaCommons Wikimedia
2.“纤维蛋白溶解”在en.wikipedia的jfdwolff，(CC BY-SA 3.0)viaCommons Wikimedia