What is the Difference Between Nicotinic Acid and Nicotinamide

Thekey difference between nicotinic acid and nicotinamide是烟酸可用于治疗高cholesterol, whereas nicotinamide is useful in treatingarthritis和佩拉格拉。

Nicotinic acid and nicotinamide are closely similar in chemical structures. Nicotinamide contains anamidegroup that is notably absent in nicotinic acid. However, they have different applications.

内容

1.Overview and Key Difference
2.What is Nicotinic Acid
3.什么是烟酰胺
4.Nicotinic Acid vs Nicotinamide in Tabular Form
6.Summary – Nicotinic Acid vs Nicotinamide

What is Nicotinic Acid?

Nicotinic acid is an organic compound having the chemical formula C₆H₅NO₂. It appears as white and translucent crystals. Nicotinic acid is also known asniacin. This substance is a form of vitamin B3 and is also an essential human nutrient. We usually get nicotinic acid from food, including both whole and processed food. The food items that give us this compound includes fortified packaged food, meat, poultry, redfish (e.g., tuna, salmon), nuts, legumes, and seeds.

As a dietary supplement, nicotinic acid is useful in treating pellagra, which is a disease that occurs from the deficiency of niacin. The symptoms of this compound’s deficiency include lesions on the skin and mouth, anemia, headache, tiredness, etc.

烟酰胺是烟酸的酰胺衍生物。因此，我们可以使用烟酰胺作为烟酸缺乏的治疗方法。这是因为烟酰胺可以通过不引起任何冲洗来以补救量进行给药。

烟酸是一种水溶性固体，是吡啶的衍生物。它在碳-3位置有一个羧基。在酰胺衍生物烟酰胺中，该羧基由羧酰胺组取代。

什么是烟酰胺?

Nicotinamide can be described as an amide chemical compound having the functional group –C(=O)NH₂. It is a form of vitamin B3 and is available in various food sources. For example, we can find this substance in yeast, meat, milk, and green vegetables. Nicotinamide is useful as a medication; we can use this substance orally to prevent and treat pellagra. Nicotinic acid or niacin is also useful as a substitute for this process, but unlike nicotinic acid, nicotinamide does not cause skin flushing. In its cream form, we can use this substance to treat acne. However, nicotinamide is an amide of nicotinic acid.

As a medication, nicotinamide has minimal side effects. However, when there are high doses of this substance inside the body, it can cause liver problems. According to research studies, normal doses are safe for use during pregnancy.

In the chemical structure of nicotinamide, there is a pyridine ring to which a primary amide group is attached in the meta position. We can categorize nicotinamide as an amide of nicotinic acid. It is an aromatic compound. Moreover, this compound can undergo electrophilic substitution reactions and transformations of its two functional groups.

What is the Difference Between Nicotinic Acid and Nicotinamide?

Nicotinic acid and nicotinamide are closely similar in chemical structures. Here, nicotinamide contains an amide group that is notably absent in nicotinic acid. The key difference between nicotinic acid and nicotinamide is that nicotinic acid is useful in treating high cholesterol, whereas nicotinamide is useful in treating arthritis and pellagra.

The below infographic presents the differences between nicotinic acid and nicotinamide in tabular form for side-by-side comparison.

Summary – Nicotinic Acid vs Nicotinamide

Nicotinic acid is an organic compound having the chemical formula C₆H₅NO₂, while nicotinamide is an amide chemical compound having the functional group –C(=O)NH₂. The key difference between nicotinic acid and nicotinamide is that nicotinic acid is useful in treating high cholesterol, whereas nicotinamide is useful in treating arthritis and pellagra.