What is the Difference Between Neurofibroma and Neurofibromatosis

Thekey difference between neurofibroma and neurofibromatosis是神经纤维瘤是一种条件benign, slow-growing nerve-sheath肿瘤成长外周神经系统，而神经纤维瘤病是一组三个疾病，其中良性肿瘤在神经系统的支持细胞和神经元中生长。

Nervous system tumors typically develop in the brain and spinal cord. They can be either benign (non-cancerous) or malignant (cancerous). The tumors that originally grow in the nervous system are primary tumors, while tumors that begin elsewhere in the body and spread to the nervous system are secondary tumors (metastatic). These tumors may affect both the central and peripheral nervous systems. Neurofibroma and neurofibromatosis are two types of conditions where benign tumors grow in the nervous system.

内容

1.Overview and Key Difference
2.What is Neurofibroma
3.什么是神经纤维瘤病
4.相似性 - 神经纤维瘤和神经纤维瘤病
5。Neurofibroma vs Neurofibromatosis in Tabular Form
6。Summary – Neurofibroma vs Neurofibromatosis

What is Neurofibroma?

Neurofibroma is a condition where benign, slow-growing nerve-sheath tumors grow in the peripheral nervous system. In 90% of cases, it is a stand-alone or solitary tumor condition. In the remaining cases, it is found in persons with neurofibromatosis type I. A neurofibroma can develop within a major or minor or nerve anywhere in the body. The symptoms are often mild or absent. However, if the tumors press against nerves or grow within them, people may experience pain or numbness in the affected area. The cause of sporadic neurofibroma is not known. But other neurofibromas arise from non-myelinatedSchwann细胞that only express the inactive version of the NF1 gene. This leads to a complete loss of expression of functional neurofibromin.

This condition has been subdivided into two categories: dermal and plexiform. Dermal neurofibromas are associated with a single peripheral nerve, while plexiform neurofibromas are associated with multiple nerve bundles. Dermal neurofibroma further divides into; cutaneous, subcutaneous, and deep nodular. The diagnosis can be made through blood tests, biopsy, MRI or electromyography (EMG/NCV). Treatments include surgery, radiation, chemotherapy, ACE inhibitors, MEK inhibitors, and drugs such as sirolimus, erlotinib, peginterferon alfa-2b, sorafenib, etc. Gene therapy for neurofibromin I gene may be a treatment option in the future.

什么是神经纤维瘤病?

Neurofibromatosis is a group of three conditions (神经纤维瘤病I，神经纤维瘤病II，和切旺瘤病），其中良性肿瘤在神经系统的支持细胞和神经元中生长。在神经纤维瘤病I中，症状包括皮肤上的浅棕色斑点，腋下雀斑和腹股沟，神经肿块和脊柱侧弯。在神经纤维瘤病II中，症状包括听力丧失，年轻时的白内障，平衡问题，肉色皮瓣和肌肉浪费。此外，在雪旺瘤病中，一个位置或身体范围内可能会出现疼痛。神经纤维瘤病通常是由神经系统的支撑细胞而不是神经元本身引起的。

神经纤维瘤病是由某些可以遗传或自发发生的基因的基因突变引起的。神经纤维瘤病I是由于NF1基因在17号染色​​体上的突变而引起的。神经纤维瘤病II是由于染色体22上NF2基因的突变引起的。Schwannomatosis是由于染色体22的各种突变引起的。基因检测。治疗计划包括手术，放射线，化学疗法，人工耳蜗或听觉脑干植入物，适用于由于这种情况而导致听力损失的人。

神经纤维瘤和神经纤维瘤病之间有什么相似之处？

• Neurofibroma and neurofibromatosis are two types of conditions where benign tumors grow in the nervous system.
• Both conditions are slow-growing.
• These conditions are generally non-cancerous.
• They can be due to genetic mutation of the NF1 gene.
• They are treatable with removal surgery, radiation and chemotherapy.

What is the Difference Between Neurofibroma and Neurofibromatosis?

Neurofibroma is a condition where benign slow-growing nerve-sheath tumors grow in the peripheral nervous system, while neurofibromatosis is a group of three conditions, neurofibromatosis I, neurofibromatosis II, and schwannomatosis, in which benign tumors grow in supporting cells and neurons of the nervous system. So, this is the key difference between neurofibroma and neurofibromatosis. Furthermore, neurofibroma affects only the peripheral nervous system, while neurofibromatosis affects both peripheral and central nervous systems.

The following table summarizes the difference between neurofibroma and neurofibromatosis.

Summary – Neurofibroma vs Neurofibromatosis

Nervous system tumors usually affect both peripheral and central nervous systems. Neurofibroma and neurofibromatosis are two types of conditions where benign tumors grow in the nervous system. Neurofibroma is a condition where benign slow-growing nerve-sheath tumors grow in the peripheral nervous system, while neurofibromatosis is a group of three conditions (neurofibromatosis I, neurofibromatosis II, and schwannomatosis) in which benign tumors grow in supporting cells and neurons of the nervous system. Thus, this summarizes the difference between neurofibroma and neurofibromatosis.

Reference:

1.“”Neurofibromas。”约翰·霍普金斯医学。
2. “Neurofibromatosis。”AANS.

Image Courtesy:

1.“”神经纤维瘤的人的背” By Seiradcruz at English Wikipedia（CC BY-SA 3.0）通过Commons Wikimedia
2. “9913People with Neurofibromatosis in the Philippines 03” Jfvelasquez Floro - 通过Commons Wikimedia自己的作品（CC0）