KeyDifference–TCellDependentvs Independent Antigens
In the context ofimmunology,抗原是具有诱导特定能力的特定分子免疫反应因此生产antibodies因此。抗体是特异性的。抗原呈递细胞是一种辅助细胞,与主要的组织相容性复合物(MHC)形成复合物以显示抗原。T细胞lymphocytesare specific cells or a subset ofwhite blood cellswhich recognize antigens selectively. Depending on theT细胞淋巴细胞,抗原有两种。T细胞依赖性抗原和T细胞独立抗原。T细胞依赖性抗原无法刺激直接激活B cellsin the production of antibodies without the assistance of T cells whilst T cell independent antigens have the ability to无需T细胞的辅助,诱导B细胞的直接刺激在抗体的产生中。This is thekey differencebetween T cell-dependent and independent lymphocytes.
内容
1.Overview and Key Difference
2.What are T Cell Dependent Antigens
3.什么是T细胞独立抗原
4.Similarities Between T Cell Dependent and Independent Antigens
5.并排比较 - T细胞依赖性与独立抗原以表格形式
6。概括
什么是T细胞依赖性抗原?
T细胞-dependent antigens are antigens that don’t have the capacity of direct stimulation of B cells in the production of antibodies without the assistance of T cells. This helps in the production ofcytokines。Cytokines can be either interferons, interleukins or growth factors. Cytokines involve in the activation, differentiation, and proliferation of B cells.
T细胞-dependent antigens are proteins. Many antigen determinants are present in T cell-dependent antigens.
什么是T细胞独立抗原?
T细胞非依赖性抗原是一种抗原,具有在无T细胞帮助的情况下诱导B细胞直接刺激B细胞的能力。T细胞非依赖性抗原是聚合物抗原,例如多糖。The responses induced to T cell independent antigens are different from a response that is induced to a typical antigen. They possess the same antigenic determinants with many repetitions, and this is a characteristic feature of T cell independent antigens.
Many types of these antigens possess the ability to activate B cell clones which are specific to the antigens. This process is known as多克隆激活。这些抗原进一步细分为两类。I型和II型。该细分是根据I型和II型细胞多克隆激活B细胞的能力进行的。Type I T cell independent antigensare considered as polyclonal activators whileII型T细胞独立抗原不是这样的激活剂。I型抗原具有必不可少的B细胞激活活性,该活性诱导了B淋巴细胞的直接增殖和分化,而B淋巴细胞的直接增殖无需B细胞。这些抗原独立于其BCR特异性。B细胞的激活是通过Toll样受体发生的,该受体一旦BCR刺激完成,就会存在于B细胞表面上。
II型抗原consist of repetitive structures known asepitopes。These cells lack the activity of B cell activation. Type II antigens activate only mature B cells. They energize the immature B cells which prevent the involvement of immature B cells in any response of the immune system. These antigens are considered to be resistance to degradations and therefore tends to persist for longer for longer periods of times carrying out the specific functions of the immune system.
T细胞依赖性和独立抗原之间的相似性是什么?
- 两种类型的抗原涉及不同的免疫反应,这些抗原通过B细胞的激活诱导抗体产生。
What is the Difference Between T Cell Dependent and Independent Antigens?
T Cell Dependent Antigen vs T Cell Independent Antigen |
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T细胞依赖性抗原是抗原,在没有T细胞的帮助的情况下,无法刺激抗体产生B细胞的直接激活。 | T细胞-independent antigens are the antigens which have the ability to induce direct stimulation of B cells in the production of antibodies without the assistance of T cells. |
Chemical Nature | |
T细胞dependent antigens are proteins. | T细胞-independent antigens are polysaccharides; polymeric antigens which also can be either glycolipids or nucleic acids. |
次级同种型 | |
Igg,Ige和IgA是T细胞依赖性的次级同种型 | IgG and IgA are the secondary isotypes of T cell independent antigens. |
概括– TCellDependentvs Independent Antigens
抗原是特定的分子,具有相应地在抗体产生中诱导特定免疫反应的能力。抗原呈递细胞通过MHC分子显示抗原。根据抗原与T细胞的相互作用,存在两种类型的抗原。它们是T细胞依赖性抗原和T细胞独立抗原。T细胞依赖性抗原在没有T细胞的帮助的情况下无法刺激抗体产生B细胞的直接激活。这些抗原由卵泡B细胞组成,由于存在记忆B细胞,可以诱导二次反应。T细胞非依赖性抗原具有在无T细胞帮助的情况下诱导B细胞直接刺激抗体的能力。它们可以进一步细分为两类。I型和II型。这是T细胞依赖性和T细胞独立抗原之间的差异。 Both types of antigens involved in different immune responses which lead to the production of antibodies by the activation of B cells.
下载T细胞依赖性与独立抗原的PDF版本
You can download PDF version of this article and use it for offline purposes as per citation note. Please download PDF version hereDifference Between T Cell Dependent and Independent Antigen
Reference:
1. “T dependent and t independent antigens.” LinkedIn SlideShare, 15 Jan. 2017. Accessed 3 Oct. 2017.Available here
2.Janeway, Charles A, and Jr. “B-Cell activation by armed helper T cells.”免疫生物学:免疫系统在健康和说ease. 5th edition., U.S. National Library of Medicine, 1 Jan. 1970. Accessed 3 Oct. 2017.Available here
Image Courtesy:
1. Altaileopard(公共领域)通过Commons Wikimedia
2. B细胞激活B细胞使Jeanne Kelly(公共领域)通过Commons WikimediaAvailable here
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