What is the Difference Between Steroidal and Nonsteroidal Anti inflammatory Drugs

Thekey differencebetween steroidal and nonsteroidal anti inflammatory drugs是类固醇抗炎药抑制磷脂酶A2酶以阻断炎症性级联反应，而非甾体类抗炎药抑制了环氧酶酶阻断炎症级联反应酶。

类固醇和非甾体类抗炎药是市场上两种不同类型的药物，可减少由于不同原因而减少人体炎症。They are widely used in medicine. Moreover, both of these molecules block the effects of inherent chemicals in the body called前列腺素促进炎症，发烧和疼痛。

内容

1.Overview and Key Difference
2.什么是类固醇抗炎药
3.What are Nonsteroidal Anti-inflammatory Drugs
4.Similarities – Steroidal and Nonsteroidal Anti-inflammatory Drugs
5.类固醇与非甾体类抗炎药的表格形式
6。Summary – Steroidal vs Nonsteroidal Anti-inflammatory Drugs

什么是类固醇抗炎药?

Steroidal anti-inflammatory drugs are a type of anti-inflammatory drug used to reduce inflammation in the human body. These drugs inhibit the phospholipase A2 enzyme from blocking the inflammatory cascade. Phospholipases, one of the main substances released during inflammation, are quickly converted to arachidonic acid by phospholipase A2. Later, arachidonic acid may enter two different arms of the inflammatory cascade. By following the pathway, it may be converted to prostaglandins by the enzyme cyclooxygenase. By following the other pathway, it may be converted toleukotrienes通过酶脂氧酶。类固醇抗炎药阻止了炎症级联反应的两个臂。

类固醇抗炎药可降低血管透明度，发红，水肿和疼痛。此外，他们保留时还具有额外的优势leukocytessequestered from the site of the inflammation by blocking the lipooxygenase arm of the inflammatory cascade. Steroids anti-inflammatory drugs may come from animals, plants, and human sources. They may constitute of sex steroids,皮质类固醇, and anabolic steroids. In the case of corticosteroids, they are used in a variety of conditions, including skin diseases, hormonal insufficiencies, and tumors. Corticosteroids are also primarily used in the treatment of joint pain and inflammation. However, they have narcotic effects and may become very addicting drugs for patients.

What are Nonsteroidal Anti inflammatory Drugs?

非甾体类抗炎药（NSAIDS）抑制环氧合酶阻止炎症级联反应。他们只堵塞了炎症级联的一只手臂。非甾体类抗炎药是减轻疼痛，炎症和发烧并防止血凝块的抗炎药类别的成员。NSAIDS通过抑制环氧合酶的酶活性（COX 1和COX2）来起作用。在细胞中，该酶分别参与称为前列腺素和血栓烷的关键生物学介质的合成，分别参与炎症和血液凝结。

非甾体类抗炎药的副作用是恶心，呕吐，过敏反应，胃肠道溃疡，出血，贫血，心脏病发作和肾脏疾病。一些最突出的NSAID是阿司匹林，布洛芬和萘普生。它们都在大多数国家 /地区的柜台上可用。

类固醇和非甾体类抗炎药之间有什么相似之处？

• 类固醇和非甾体类抗炎药是市场上两种不同类型的药物，可减少由于不同原因而减少人体炎症。
• Both drug classes can reduce inflammation, pain, and fever.
• 他们有副作用。
• They are easily available in the market.

What is the Difference Between Steroidal and Nonsteroidal Anti-inflammatory Drugs?

类固醇抗炎药抑制磷脂酶A2酶阻断炎性级联反应，而非甾体类抗炎药抑制了环氧酶阻断炎症级联反应酶。因此，这是类固醇和非甾体类抗炎药之间的关键区别。此外，类固醇抗炎药阻断了炎症级联反应的两个臂，而非甾体类抗炎药仅阻止炎症级联反应的一个手臂。

The below infographic presents the differences between steroidal and nonsteroidal anti-inflammatory drugs in tabular form for side-by-side comparison.

Summary – Steroidal vs Nonsteroidal Anti-inflammatory Drugs

Steroidal and nonsteroidal anti-inflammatory drugs are two different types of prominent anti-inflammatory drug classes. Steroidal anti-inflammatory drugs inhibit phospholipase A2 from blocking the inflammatory cascade. Nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase enzyme from blocking the inflammatory cascade. So, this summarizes the difference between steroidal and nonsteroidal anti inflammatory drugs.

Reference:

1.“”Corticosteroids.” Cleveland Clinic.
2. “NSAIDS。” NHS选择，NHS。

Image Courtesy:

1.“”Cortisol for injection” By LHcheM – Own work(CC BY-SA 3.0)通过Commons Wikimedia
2. “200mg布洛芬片” By Ragesoss – Own work(CC BY-SA 3.0)通过Commons Wikimedia