Difference Between Markovnikov and Anti-Markovnikov Rule

Key Difference – Markovnikov vs Anti-Markovnikov Rule

In the early 1870s, a Russian chemist named Vladimir Markonikov derived a rule based on a series of empirical observations. The rule was published as the Markovnikov’s rule.The Markovnikov’srule helps to predict the resulting formula ofalkane, when acompoundhaving the general formula of HX (HCl, HBr or HF) or H₂O is added to an asymmetric alkene (such aspropane). It is possible to reverse the minor and major products when the reaction conditions are changed, andthis process is referred to as Anti-Markovnikov addition.Thekey differencebetween Markovnikov rule and the anti-Markovnikov rule is explained below.

CONTENTS

1.Overview and Key Difference
2.What is Markovnikov Rule
3.What is Anti-Markovnikov Rule
4.Side by Side Comparison – Markovnikov vs Anti-Markovnikov Rule in Tabular Form
5.Summary

What is Markovnikov Rule?

The definition of Markovnikov rule is, when the addition of protic acid with the formula of HX (where X=halogen) or H₂O (considered as H-OH) to an alkene, hydrogen attaches to the double bonded carbon with the greater number of hydrogen atoms, while the halogen (X) attaches to the other carbon. Therefore, this rule is often interpreted as ‘the rich get richer’. The rule can be illustrated using the reaction of propene with hydrobromic acid (HBr) as follows.

The same rule is applied when an alkene reacts with water to formalcohol. Thehydroxylgroup (-OH) adds to the double-bonded carbon with the greater number of C-C bonds, while the hydrogen atom (H) adds to the other double bonded carbon that has more C-H bonds. Therefore, according to Markovnikov rule, when an HX is added to an alkene, the major product has H atom in the less substituted position while the X in the more substituted position. Therefore, this product is stable. However, it is still possible to form a less stable product, or we call it a minor product, in which H atom bonds to more substituted position of the C=C bond, while X bonds to the less substituted position.

The mechanism of the addition of HX to an alkene can be explained in two steps (See fig 02). First, the addition of a proton (H⁺)是发生C = C双键的烯烃reacts with H⁺of HX (in this case it’s HBr) to form a carbonation intermediate. Then reaction of anelectrophile and a nucleophileis taken place as the second step to form a newcovalent bond. In our case, Br^–reacts with carbonation intermediate which is positive in charge to form the final product.

What is Anti-Markovnikov Rule?

Anti- Markovnikov rule explains the opposite of the original statement of Markovnikov’s rule. When HBr is added to an alkene in the presence ofperoxide, H atom bonds to double-bonded carbon that has less C-H bonds, while Br bonds to the other carbon that has more C-H bonds. This effect is also known asKharash effectorperoxide effect. The anti- Markovnikov addition also takes place when reactants are exposed to ultraviolet light. This is the exact opposite of Markovnikov rule. However, the anti-Markovnikov rule is not the exact reverse process of Markovnikov addition as the mechanisms of these two reactions are entirely different.

Markovnikov reaction is an ionic mechanism, whereas anti-Markovnikov reaction is a free-radical mechanism. The mechanism takes place as a chain reaction and has three steps. The first step is the chain-initiating step, where photochemical dissociation of HBr or peroxide is taken place to form Br and H free radicals. Then in the second step, Br free radical attacks the alkene molecule to form two possible bromoalkyl free radicals. 2° free radical is more stable and formed predominantly.

During the final step, the more stable bromoalkyl free radical reacts with HBr forming anti-Markovnikov product plus another bromine free radical, which continuous the chain reaction. Unlike HBr, HCl and HI do not result in anti-Markovnikov products as they do not undergo free radical addition reaction. It is because H-Cl bond is stronger than H-Br bond. Even though H-I bond is much weaker, the formation of I₂is more preferred as C-I bond in relatively unstable.

What is the Difference Between Markovnikov and Anti Markovnikov Rule?

Markovnikov vs Anti Markovnikov Rule
Markovnikov Rule explains when the addition of protic acid with the formula of HX (where X= halogen) or H2O (considered as H-OH) to an alkene, hydrogen attaches to the double bonded carbon with the greater number of hydrogen atoms, while the halogen (X) attaches to the other carbon.	Anti-Markovnikov Rule explains when HBr is added to an alkene in the presence of peroxide, H atom bonds to double-bonded carbon that has less C-H bonds, while Br bonds to the other carbon that has more C-H bonds
Mechanism
Ionic mechanism	Free radical mechanism
Reactants
HCl, HBr, HI or H2O	Only HBr (not HCl or HI undergo this addition reaction)
Medium/Catalyst
No medium is required	Peroxide or ultraviolet must be present

Summary –Markovnikov vs Anti-Markovnikov Rule

Markovnikov and anti-Markovnikov are two types of addition reactions occurring between HX (HBr, HBr, HI and H₂O) and alkenes. Markovnikov reaction occurs when the addition of HX to an alkene, where H bonds to less substituted carbon atom of the double bond, while X bonds to the other double bonded carbon atom through an ionic mechanism. The anti-markovnikov reaction takes place when HBr (not HCl, HI or H2O) is added to an alkene, where Br bonds to less substituted double-bonded carbon, while H bonds to the other carbon atom, through a free radical mechanism. This is the difference between Markovnikov and Anti-Markovnikov Rule.

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Reference:

1.Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, and Shawn O. Farrell. (2012). Introduction to General, Organic, and Biochemistry, Cengage Learning Publications.
2.Murthy, C. P. (2008). University Chemistry(Vol. 1). New Age International
3.Bhagi, A, and Raj, G. (2010), Krishna’s I.A.S. Chemistry, Krishna Prakashan Media.

Image Courtesy:

1.’MarkovnikovRulePropeneHBr’ By V8rik (talk) – Own Work,(CC BY-SA 3.0)viaCommons Wikimedia
2.’HBr-Addition’By Eschenmoser – Own work (Public Domain) viaCommons Wikimedia
3.’Anti-markovnikov examples’ By Mfomich – Own work, (Public Domain) viaCommons Wikimedia