Thekeydifferencebetween CRP and homocysteine is that theC reactive protein (CRP) is a pentameric protein while the homocysteine is a non-proteinogenic alpha氨基酸.
Inflammation is a complex biological response developed against different harmful stimuli such as pathogens, damaged cells in the body, or irritants. It involves immune cells, molecular mediators and blood vessels. Moreover, different markers indicate possible inflammatory conditions. Hence, these markers are used at clinical levels to identify different disease conditions related to inflammation. C reactive protein (CRP) and homocysteine are two such markers.
内容
1.Overview and Key Difference
2.What is CRP
3.What is Homocysteine
4.Similarities Between CRP and Homocysteine
5.Side by Side Comparison – CRP vs Homocysteine in Tabular Form
6。概括
What is CRP?
C Reactive Protein (CRP) is a pentameric protein present in血浆. It is a member of a pentraxins protein family with a monomer of 224 amino acids. The molecular mass of CRP is 25,106 Da. The gene that encodes CRP protein is present on chromosome 1. Furthermore, the CRP levels drastically rise in response to inflammation. Also, the CRP synthesis occurs in the liver in response to signalling factors released by巨噬细胞and adipocytes during an inflammation.
Furthermore, CRP is an acute phase protein of hepatic origin. The increment in the level of CRP occurs due to the secretion of白介素-6 by T lymphocytes and macrophages. Hence, the first pattern recognition receptor (PRR) identified during inflammation is the CRP.
此外,CRP的生理作用涉及与溶物磷脂酰胆碱的结合,后者存在于垂死或死细胞表面上。绑定后,它通过补体组件1q(C1Q)激活补体途径。因此,这促进了巨噬细胞的吞噬作用,并清除凋亡细胞,坏死细胞和细菌。
What is Homocysteine?
同型半胱氨酸是一种非蛋白质生成α氨基酸,它是具有额外亚甲基桥的半胱氨酸氨基酸的同源物。人体无法从饮食中获得同型半胱氨酸。因此,同型半胱氨酸的生物合成是通过蛋氨酸的多步骤过程发生的,并去除末端碳甲基。通过B维生素,同型半胱氨酸有可能根据需要转化回蛋氨酸或半胱氨酸。
Besides, abnormal levels of homocysteine cause various disease conditions. Increment from the normal level of homocysteine causes hyperhomocysteinemia. And, this disease condition results in endothelial cell injury. It leads to blood vessel inflammation and converts to atherogenesis. Finally, it causes ischemic injury (restriction in the supply of blood to tissues). Therefore, hyperhomocysteinemia act as a possible risk for coronary heart disease. It occurs due to blocking of blood flow to the coronary arteries by an atherosclerotic plaque. Thus, this limits the supply of oxygenated blood to the heart.
高栓塞血症与中风,心脏病发作和血液凝块的发生之间存在相关性。但是,目前尚不清楚多型半胱氨酸血症是否是这种疾病的独立危险因素。同样,由于高栓塞性半胱氨酸血症,可能会出现早期妊娠丧失和神经管缺陷。
CRP和同型半胱氨酸之间有什么相似之处?
- CRP and Homocysteine are markers of inflammation.
- High levels of both types indicate disease conditions.
- 另外,它们都存在于血液中。
- Both can be measured at clinical levels.
- 此外,它们是炎症和其他疾病类型的可靠临床指标。
What is the Difference Between CRP and Homocysteine?
CRP is a protein while homocysteine is a non-proteinogenic amino acid. Therefore, this is the key difference between CRP and homocysteine. Furthermore, CRP synthesis occurs in the liver while homocysteine biosynthesis occurs from methionine through a metabolic pathway. Hence, this is also a difference between CRP and homocysteine.
以下infographic on the difference between CRP and homocysteine provides a more detailed comparison.
摘要 - CRP与同型半胱氨酸
Different markers indicate inflammatory reaction conditions in our body. Among the many different markers, C reactive protein and homocysteine are two important inflammatory markers. CRP is a pentameric protein present in blood plasma whose level rises due to inflammation. Accordingly, the liver is the organ that synthesizes CRP in response to signalling factors released by macrophages and adipocytes.
另一方面,同型半胱氨酸是一种非蛋白质生成α氨基酸,它是氨基酸半胱氨酸具有额外的甲基桥的同源物。因此,从正常同型半胱氨酸的正常水平的增量会导致高脑结膜血症,从而导致缺血性损伤。此外,高层结构血症也是冠心病的可能风险。因此,这是CRP和同型半胱氨酸之间的差异。
Reference:
1.”Homocysteine.”. “Homocysteine.” The Columbia Encyclopedia, 6th Ed, Encyclopedia.com, 2018.Available here
2.Protein.”, “C-Reactive. “C-Reactive Protein.” The Columbia Encyclopedia, 6th Ed, Encyclopedia.com, 2018.Available here
Image Courtesy:
1.”PDB 1b09 EBI”By Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute (Public Domain) viaCommons Wikimedia
2.”L-Homocysteine-3D-balls”By Ben Mills and Jynto (Public Domain) viaCommons Wikimedia
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