Difference Between Cortisone and Cortisol (Hydrocortisone)

Cortisone vs Cortisol (Hydrocortisone)

Cortisol and Cortisone are both类固醇. They share a similar core chemical structure which is common to all the cholesterol-like molecules. They comprise 4 fused Carbon rings and, therefore, have a very rigid structure. The difference between cortisol and cortisone lies in the difference of the functional groups present in the two molecules.

Cortisol

Cortisol is also known ashydrocortisone. It is a steroid hormone which is released by the adrenal cortex. This is a “stress hormone” that gets released in order to show “fight or flight response” at stressful conditions. Cortisol can increase blood sugar bygluconeogenesis. It is classified as a glucocorticoid which can stimulate liver glycogen formation. It also has the ability to suppress the immune system and acts as an anti-inflammatory compound. Thesystemic name of cortisolis(11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione. The CRH hormone released by下丘脑triggers secretion of ACTH hormone from theanterior pituitaryand then ACTH triggers the release of Cortisol.

Cortisol has the ability to reduce substances that are responsible for inflammatory response. Therefore, it is administrated as a drug for rheumatoid diseases and allergies. Sometimes it is also used to treat skin rashes and eczema. If the cortisol level in the body is constantly high, it can lead to proteolysis and hence muscle wasting. This can also reduce bone formation. Cortisol also has the ability to act as anantidiuretic hormone. When the level of cortisol declines the water excretion too declines.

Cortisone

Cortisone is also another steroidal hormone, a glucocorticoid to be specific which is released by adrenal glands. It also has the ability to act as an anti-inflammatory compound and anantidiuretic hormone. The皮质康酮的系统名称is17-hydroxy-11-dehydrocorticosterone. When it comes to glucocorticoid activity, cortisone could be considered as the inactive form of cortisol. Cortisone is activated to become cortisol by the hydrogenation of theketonegroup in the 17^thCarbon to analdehydegroup.

Cortisone, like cortisol, has the ability to elevate blood pressure in stressful conditions. It is also used as an anti-inflammatory drug and as a short term pain relief especially for joint pains.

之间的区别是什么皮质醇(hydrocortisone) and Cortisone?

•皮质醇和可的松都是类固醇。

•皮质醇和可的松在结构上不同。皮质醇有一个醛组，该醛连接到类固醇核心碳骨架的第17个碳。可可酮的酮组。

• Cortisol is the active form when it comes to glucocorticoid activity. Cortisone is a precursor that could be converted to cortisol upon hydrogenation of the ketone group at 17th position into an aldehyde group.

•皮质醇的半衰期为3小时，而可皮质康酮只有½小时。