Thekey differencebetween co and post translational modification is thatco-translational modification is a type ofproteinmodification which occurs during the synthesis while post-translational modification is a type of modification that occurs after the initial synthesis is completed.
蛋白质是活生物体的必不可少的大量营养素。基因通过gene expression. Gene expression takes place through two major steps:转录和翻译. Gene expression is a complex process which is tightly regulated in order to produce an accurate and fully functional protein. Hence, there are modifications occurring during the gene expression. There are three levels of protein modifications. They are pre translational, co-translational and post-translational modifications. Co-translational modifications take place during the translation process while post-translational modifications take place after translation or protein synthesis. As a result of all these modifications, a mature protein product which is crucial for cells is formed at the end of the gene expression.
Co translational modifications are a type of protein modifications that take place during translation. Therefore, these modifications happen during protein synthesis. Co-translational modifications mainly occur inRER. Newly synthesizing polypeptides undergo co-translational modifications. Some of the co-translational modifications are regulation of translation, protein folding and processing, myristoylation, prenylation and palmitoylation.N-linked glycosylation is a step involved in protein folding in the RER. Moreover, molecular chaperons in RER facilitate protein folding.
What is a Post Translational Modification?
- Co and post-translational modifications are two of the three levels of protein modifications.
- Both types are structural modifications.
- They take place during and after translation.
- Both co and post-translational modifications take place in RER.
Co-translational modification is a type of protein modification which happens during the translation while the post-translational modification is a type of protein modification which happens after translation. Thus, this is the key difference between co and post translational modification. Co translational modifications happen mainly in the RER while post-translational modifications happen in different organelles including RER, Golgi, endosomes, lysosomes and secretory vesicles.
Moreover, regulation of translation, protein folding and processing, myristoylation, prenylation and palmitoylation are several co-translational modifications while phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation and proteolysis are several post-translational modifications.
Below is a summary of the difference between co and post translational modification in tabular form.
概括– Co vs Post Translational Modification
1. Shandala, Tetyana, et al. “Protein: Cotranslational and Posttranslational Modification in Organelles.” Wiley Online Library, American Cancer Society, 17 Jan. 2011,Available here.
2.“翻译后修改的概述：Thermo Fisher Scientific - US。”翻译后修改概述|Thermo Fisher Scientific - 美国，Available here.