Difference Between Cholinergic and Anticholinergic

Thekey differencebetween cholinergic and anticholinergic is thatcholinergic agents mimic the action of乙酰胆碱而抗胆碱能剂阻止了乙酰胆碱的作用.

Acetylcholine is an organic compound. It functions as aneurotransmitterin the brain and body of many animals and humans. It is important in sending chemical messages between cells, neurons and among other cells such as muscle cells and gland cells. Both cholinergic and anticholinergic are related to acetylcholine. These refer to chemical agents that can regulate the neurochemical message transfer between neurons and cells.

内容

1.Overview and Key Difference
2.What is Cholinergic
3.What is Anticholinergic
4.Side by Side Comparison – Cholinergic vs Anticholinergic in Tabular Form
5.概括

What is Cholinergic?

Cholinergic agents are chemical compounds that can mimic the function of acetylcholine. These agents can mimic the function of butyrylcholine as well. “choline” is a component of the neurotransmitter acetylcholine. Theparasympathetic nervous systemis said to be entirely cholinergic because it uses acetylcholine almost exclusively to send messages between cells and targets. In addition, neuromuscular junctions and preganglionic neurons of the sympathetic nervous system are cholinergic. The receptors of merocrine sweat glands are also cholinergic.

可以产生，改变或释放乙酰胆碱或丁甘氨酸的物质或配体也称为胆碱能剂。此外，如果受体或突触使用乙酰胆碱作为神经递质，则它们也被称为胆碱能剂。

What is Anticholinergic?

抗胆碱能剂是可以阻止乙酰胆碱作用的物质。这种阻滞主要发生在central and peripheral nervous system. These agents can selectively block the binding of acetylcholine with receptors in nerve cells of the peripheral nervous system. There are three types of anticholinergic agents:

1. Antimuscarinic blockers
2. 神经节阻滞剂
3. Neuromuscular blockers

Anticholinergic drugs are very important in the field of medicine to treat various diseases such as dizziness, extrapyramidal symptoms, gastrointestinal disorders, insomnia, respiratory disorders, etc. However, there are side effects of using this drug as well.

1. Poor coordination
2. 失智
3. Decreased mucus production in the nose and throat
4. Dry mouth with increase dental caries
5. 体温升高，等等。

What is the Difference Between Cholinergic and Anticholinergic?

The key difference between cholinergic and anticholinergic is that cholinergic agents mimic the action of acetylcholine, whereas anticholinergic agents block the action of acetylcholine. Moreover, cholinergic agents can act on parasympathetic and sympathetic nervous systems, while anticholinergic agents act mainly on the central and peripheral nervous system. Besides, examples of cholinergic drugs include pilocarpine, physostigmine, etc. Meanwhile, examples of anticholinergic drugs include atropine, clidinium, Cogentin, etc.

以下信息图总结了表格形式的胆碱能和抗胆碱能之间的差异。

概括– Cholinergic vs Anticholinergic

The terms cholinergic and anticholinergic refers to chemical agents that can regulate the neurochemical message transfer between neurons and cells. The key difference between cholinergic and anticholinergic is that cholinergic agents mimic the action of acetylcholine whereas anticholinergic agents block the action of acetylcholine. Cholinergic agents can act on parasympathetic and sympathetic nervous systems while anticholinergic agents act mainly on the central and peripheral nervous system.

Reference:

1. “Cholinergic Drug.” Encyclopædia Britannica, Encyclopædia Britannica, Inc., 26 July 2019,Available here.
2. “Cholinergic.” Wikipedia, Wikimedia Foundation, 17 Dec. 2019,Available here.
3.“抗胆碱能。”维基百科，维基梅迪亚基金会，2020年3月11日，Available here.

Image Courtesy:

1. “Acetylcholine” By Vectorization: OmenBreeze – Own work based on: Choline-skeletal.png by Benjah-bmm27. (CC0) viaCommons Wikimedia
2. “Choline-skeletal” By Harbin – Own work (Public Domain) viaCommons Wikimedia