What is the Difference Between PCV13 and PPSV23

Thekey differencebetween PCV13 and PPSV23是PCV13（13价肺炎球菌结合疫苗）是一种疫苗肺炎其中包含13抗原from common serotypes, while PPSV23 (23-valent pneumococcal polysaccharide vaccine) is a vaccine against pneumonia that contains 23 antigens from common serotypes.

肺炎是一种呼吸道疾病，在世界范围内引起明显的发病率和死亡率。Streptococcus pneumoniaebacterium is the most commonly identified pathogen that causes community-acquired pneumonia. In the United States,S. pneumoniaeis responsible for 500,000 cases of pneumonia and 50,000 cases of bacteremia each year. In addition to the public health concerns, pneumonia also accounts for a huge cost to the health care system. There are two vaccines currently targetingS. pneumoniae。这两种疫苗是PCV13和PPSV23。

内容

1.Overview and Key Difference
2.What is PCV13
3.What is PPSV23
4.Similarities – PCV13 and PPSV23
5.PCV13 vs PPSV23 in Tabular Form
6。摘要 - PCV13 vs PPSV23

What is PCV13?

PCV13（13个价值肺炎球菌缀合物疫苗）是一种针对由肺炎链球菌引起的肺炎的疫苗。该疫苗含有13种来自常见血清型的抗原。PCV13的另一个名称是PREVNAR 13.这是一个共轭疫苗that is normally used to protect infants, young children, and adults against pneumonia caused by the bacteriumStreptococcus pneumoniae。It contains purified capsular polysaccharides of pneumococcal serotypes conjugated to acarrier protein。Normally this carrier protein is a diphtheria carrier protein. This conjugation improves the antibody response.

The world health organization recommends this conjugate vaccine in routine immunization of children. Moreover, this PCV13 conjugate vaccine is manufactured by Pfizer (formerly Wyeth) company. The thirteen serotypes of pneumococcus in this vaccine are 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F. PCV 13 was approved by European Union in December 2009. In February 2010, it was approved in the United States to replace the pneumococcal 7-valent conjugate vaccine.

这种疫苗的副作用是发红，疼痛，疼痛，嫩痛，发烧，食欲不振，烦恼，疲倦，头痛，发冷等。此外，患者应立即与医疗保健提供者联系，以寻求严重的过敏反应这种结合疫苗的疫苗接种。

What is PPSV23?

PPSV23（23个价值肺炎球菌多糖疫苗）是一种针对由肺炎链球菌引起的肺炎的疫苗。这个polysaccharide vaccinecontains 23 antigens from common serotypes. PPSV23 can prevent a pneumococcal disease similar to the PCV13 vaccine. In addition to pneumonia, PPSV23 can also prevent ear infections, sinus infections, meningitis and bacteremia.

PPSV23 is recommended for all adults 65 years or older and anyone 2 years or older with certain medical conditions. Generally, PPSV23 provides protection against 23 types of bacteria that cause pneumococcal disease. PPSV23 is very important for those who suffer from HIV/AIDS. The serotypes present in the vaccine are 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, and 33F. This vaccine also can give side effects such as redness, soreness, or pain where a shot is given, tiredness, weakness, swelling or thickening of the injection site, fever, muscle ache and severe allergic reactions, etc.

What are the Similarities Between PCV13 and PPSV23?

• PCV13 and PPSV23 are two vaccines that target the bacterium肺炎e。
• Both vaccines contain capsular polysaccharides of pneumococcal serotypes.
• 这些疫苗治疗肺炎球菌病。
• Both vaccines prevent ear infections, sinus infections, meningitis, bacteremia, in addition to pneumonia.
• PCV13中包含的13种血清型中的十二种是PPSV23共有的。

PCV13和PPSV23有什么区别？

PCV13 is a vaccine against pneumonia that contains 13 antigens from common serotypes, while PPSV23 is a vaccine against pneumonia that contains 23 antigens from common serotypes. So, this is the key difference between PCV13 and PPSV23. Furthermore, PCV13 covers a smaller number of pneumococcal serotypes but may induce effective, long-lasting immunity, while PPSV23 covers a greater number of pneumococcal serotypes but may not induce effective long-lasting immunity.

The below infographic lists the differences between PCV13 and PPSV23 in tabular form for side by side comparison.

摘要 - PCV13 vs PPSV23

Streptococcus pneumoniaeis the most commonly identified pathogen that causes community-acquired pneumonia. There are two vaccines currently targetingS. pneumoniae。它们是PCV13和PPSV23。PCV13可预防13种类型Streptococcus pneumoniaebacteria that cause pneumococcal disease, while PPSV23 protects against 23 types ofStreptococcus pneumoniae引起肺炎球菌疾病的细菌。因此，这是PCV13和PPSV23之间的关键区别。

Reference:

1.“”肺炎球菌结合疫苗信息声明。”疾病控制与预防中心，疾病控制与预防中心，2021年8月6日。
2. “肺炎球菌多糖疫苗信息声明。”疾病控制与预防中心，疾病控制与预防中心，2019年10月30日。

Image Courtesy:

1.“”Prevenar, Pneumococcal conjugate vaccine (PCV13)” By Whispyhistory – Own work(CC BY-SA 4.0)通过Commons Wikimedia
2. “Pneumovax 23” By Waddie96 – Own work(CC BY-SA 4.0)通过Commons Wikimedia