这key difference between MCAS and histamine intolerance是MCA是一种免疫学条件mast cellsinappropriately release excessive chemical mediators, while histamine intolerance is a condition where dietary histamine accumulates in the body.
组胺是一种参与人体局部免疫反应的氮化合物。它还调节生理功能,充当神经递质对于大脑,脊髓和子宫。它于1910年被发现。从那时起,它被认为是局部激素。作为不可或缺的一部分免疫系统,组胺可能参与MCAS等免疫系统疾病。它也可能参与组胺不平衡条件,例如组胺不耐症。MCAS和组胺不耐受是由于体内组胺过度累积的两种情况。
CONTENTS
1。概述和关键差异
2。What is MCAS
3。什么是组胺不耐受
4。Similarities – MCAS and Histamine Intolerance
5.MCAS vs组胺不耐受为表格形式
6.摘要 - MCAS vs组胺不耐受
What is MCAS?
Mast cell activation syndrome(mca)是一个类型的肥大细胞活化障碍and an immunological condition where mast cells inappropriately release excessive chemical mediators. These chemical mediators include leukotrienes, histamines, prostaglandins, and tryptase. There are no known causes for this disorder, but it appears to be inherited in some patients. This condition may be mild. However, it can exacerbate due to stressful life events. The symptoms include flushing, hives, itchiness, light-headedness, diarrhoea, nausea, congestion, coughing, and anaphylaxis.
MCAS仍然是一个鲜为人知的状况。此外,这是当前的研究主题。可以通过测量肥大细胞介质升高来诊断在实验室中。由于症状的异质性,MCA通常难以识别。世界卫生组织尚未发布MCAS的诊断标准。治疗方法包括肥大细胞稳定剂(Cromolyn钠),H1-抗组织胺(西替利嗪),H2-抗组织胺(Ranitidine),抗乳杆菌(Montelukast)和非甾体类抗炎抗炎药。
什么是组胺不耐受?
Histamine intolerance is a condition where dietary histamine accumulates in the body. The intolerance is caused usually by the gradual accumulation of extracellular histamine due to an imbalance. People naturally produce histamine along with an enzyme that is responsible for breaking histamine: diamine oxidase. Diamine oxidase deficiency causes the inability of histamine breakdown leading to histamine intolerance. The symptoms include headaches, nasal congestions, fatigue, hives, digestive issues, irregular menstrual cycle, nausea, vomiting, abdominal cramping, tissue swelling, irregular heart rate, anxiety, difficulty regulating body temperature, and dizziness.
大约1%的人口具有组胺不耐受。其中80%是中年人。有一些食品,例如酒精,发酵食品,干果,鳄梨,茄子,菠菜,贝类,老年奶酪等,含有较高的组胺,这会触发炎症反应。刺测试可用于诊断组胺不耐症。治疗方法包括抗组胺药,用于皮疹的局部类固醇霜和补充剂,以减少组胺,例如维生素C,B6,Zn,Cu,Cu,镁,槲皮素,DAO启动子。
What are the Similarities Between MCAS and Histamine Intolerance?
- MCAS和组胺不耐受是由于体内组胺过度累积的两种情况。
- 在这两种情况下,患者体内的肥大细胞数量正常。
- 这y cause similar symptoms such as rashes, hives, etc.
- 抗组胺药可用于治疗这两种情况。
What is the Difference Between MCAS and Histamine Intolerance?
MCAS是一种肥大细胞活化障碍,是一种免疫学疾病,肥大细胞不适当释放过多的化学介质,而组胺不耐症是饮食中组胺在体内积累的疾病。因此,这是MCA和组胺不耐受之间的关键区别。此外,在MCA中,肥大细胞具有高反应性,而在组胺不耐受中,肥大细胞没有过度反应性。
以下信息图列出了与表格形式的MCAS和组胺不耐受的差异,以与并排比较。
摘要 - MCAS vs组胺不耐受
组胺是一种参与人体局部免疫反应的氮化合物。MCAS和组胺不耐受是体内组胺过度淘汰的两个条件。MCAS是一种免疫学条件,肥大细胞不适当释放过多的化学介质,而组胺不耐症是饮食中组胺在体内积累的疾病。因此,这是MCA和组胺不耐受之间差异的摘要。
参考:
1. M. Frieri。“Mast Cell Activation Syndrome。”美国国家医学图书馆过敏和免疫学的临床评论
2.“”组胺不耐受:症状,饮食和治疗。”Amy Burkhart, MD, RD, 11 May 2021.
图片提供:
1。“Blausen 0018过敏反应” By Blausen.com staff (2014). “Medical gallery of Blausen Medical 2014” WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. – Own work(CC由3.0)via Commons Wikimedia
2.“”Rash”伊诺克劳(Enochlau) - 自己的作品(CC BY-SA 3.0)via Commons Wikimedia
米里亚姆says
As someone diagnosed with mast cell. And my children have had to deal with it all their lives too. This article feels simplistic about mast cell issues whether histamine intolerance can be clearly separated. I was disappointed as i feel the question is helpful but the content feels subjective and limited. For example anyone I know with mast cell would identify with all symptoms you have listed in both columns x