What is the Difference Between Hemophilia A and B and C

这关键区别在血友病A和B和C之间is that hemophilia A is due to the deficiency of凝血因子VIII, while hemophilia B is due to the deficiency of clotting factor IX and hemophilia C is due to the deficiency of clotting factor XI.

血友病aand B are due to an inheritedX连锁隐性trait with a defective gene located on the X chromosome. Males have one X chromosome, and females have two X chromosomes. In males, the individual diagnosed with hemophilia contain a defective gene on the X chromosome. Therefore, most patients with hemophilia are males. Hemophilia C does not follow any X-linked pattern since the mutation occurs in a gene located on chromosome 4. Therefore, hemophilia C affects both genders equally.

CONTENTS

1。概述和关键差异
2。什么是血友病A
3。什么是血友病B
4。什么是血友病C
5.Similarities – Hemophilia A and B and C
6.血友病A VS B VS c以表格形式
7.摘要 - 血友病A VS B vs c

什么是血友病A？

血友病A是由于缺乏血液凝血因子VIII引起的遗传性出血障碍。VIII因子对于血液凝结程序很重要。当发生小切割或出血损伤时，会发生一系列反应以帮助血凝块。这个过程称为coagulation cascade。它涉及称为凝血因子的特殊蛋白质。VIII因子就是这样的凝结因子。血友病A的重要部位是关节，肌肉，大脑和消化道。肌肉和关节出血，脑和消化道出血是血友病的迹象A.血友病A的其他症状是严重或轻度损伤的血液凝结不足；在严重的情况下，它可能导致自发出血。

Diagnosis for hemophilia A is made using coagulation factor assays. Most treatments for hemophilia include replacing the missing or deficient protein factor VIII. Therefore, the main medication is concentrated factor VIII called the clotting factor. There are two types of this factor: plasma-derived and recombinant. And, these factor therapies are injected into a vein.

什么是血友病B？

血友病bis a hereditary bleeding disorder caused due to the lack of blood clotting factor IX. Lack of factor IX is rare than other factors, and therefore, hemophilia B is a rare disorder. Symptoms of hemophilia B include easy bruising, urinary tract bleeding called hematuria, nose bleeding called epistaxis, and bleeding in joints known as hemarthrosis. Patients affected with hemophilia B show higher periodontal diseases with a lack of oral hygiene and health care.

血友病B的最突出症状是在牙齿或拔牙发射期间出血。严重的血友病B会引起口腔组织，嘴唇和牙龈的自发出血。IX因子缺乏会导致自发出血或轻度创伤，如果不立即治疗。血友病B的诊断是通过凝结筛查测试，凝结因子测定和出血评分进行的。血友病B的治疗包括因子IX和输血的静脉输注。

什么是血友病C？

血友病C，也称为血小板凝血素的先决性缺乏，由于血液凝结因子XI的缺乏，是一种温和的血友病形式。血友病C是一种常染色体隐性遗传，因为该基因位于4号染色体上。嗜血症C有时在患有红斑狼疮的个体中可见。患有血友病C的个体不会自发流血。因此，诸如出血之类的并发症最有可能在手术或严重受伤后发生。然而，血友病C的症状包括口腔出血，鼻子出血，尿液血液，产后出血和扁桃体出血。

Diagnosis of hemophilia C is dependent on prolonged activated partial thromboplastin time study. It is a blood test that characterizes the coagulation of blood with time. Treatment for hemophilia C is medication tranexamic acid during or after an incident of bleeding. Fresh frozen plasma or recombinant factor XI is injected in serious incidents.

血友病A和B和C之间有什么相似之处？

• 血友病a, B, and C are associated with the deficiency of blood clotting factors.
• 这y are genetic disorders.
• Moreover, all three types are responsible for spontaneous hemorrhages.
• Molecular techniques such as PCR can be used to diagnose all three conditions.

血友病A和B和C之间有什么区别？

由于缺乏血液凝血因子VIII，IX和XI，血友病A，B和C是遗传性出血疾病。因此，这是血友病A和B和C之间的关键区别。此外，血友病A和B主要在男性中看到，而血友病C则同样影响两个性别。此外，血友病A和B是X连锁隐性的，而血友病C是常染色体隐性。

以下信息图显示了与表格形式的血友病A和B和C之间的差异。

摘要 - 血友病A VS B vs c

血友病A是由于缺乏血液凝血因子VIII引起的遗传性出血障碍。血友病B是由于缺乏血液凝血因子IX引起的遗传性出血障碍。血友病C，也称为血小板凝血素的先决性缺乏，由于血液凝结因子XI的缺乏，是一种温和的血友病形式。血友病A和B是由于遗传的X连锁隐性特征，其基因位于X染色体上。相反，血友病C与染色体基因的缺陷有关。因此，这总结了血友病A和B和C之间的差异。

参考：

1。“血友病a。” MedlinePlus, U.S. National Library of Medicine.
2.“”血友病b。” MedlinePlus, U.S. National Library of Medicine.

图片提供：

1。“X连锁隐性(2)” By File:Autosomal recessive – en.svg: Domaina, Kashmiri and SUM1Derivative work: SUM1 – Based off of File:Autosomal recessive – en.svg（CC BY-SA 4.0）via Commons Wikimedia
2.“”血友病诊断图3” By Moutasem z – Own work（CC BY-SA 3.0）via Commons Wikimedia