COX 1和COX 2抑制剂有什么区别

Thekey differencebetween COX 1 and COX 2 inhibitors是Cox 1抑制剂是non-steroidal anti-inflammatory drugthat inhibits cyclooxygenase-1 enzyme expressed constitutively in most tissues while COX 2 inhibitor is a non-steroidal anti-inflammatory drug that inhibits cyclooxygenase-2 enzyme expressed in areas of inflammation.

Non-steroidal anti-inflammatory drugs (NSAIDS) usually provide anti-inflammatory,止痛剂, andantipyreticeffects. They are used in the treatment of a variety of diseases. Non-steroidal anti-inflammatory drugs inhibit a particular rate-limiting enzyme called cyclooxygenase (COX) involved in the production of prostaglandins. Two isoforms of this enzyme have been identified: COX 1 and COX 2. COX 1 inhibitor and COX 2 inhibitor are two non-steroidal anti-inflammatory drugs involved in the inhibition of cyclooxygenase 1 (COX 1) and cyclooxygenase 2 (COX 2), respectively.

内容

1.Overview and Key Difference
2.什么是Cox 1抑制剂
3.什么是Cox 2抑制剂
4.相似性 - COX 1和COX 2抑制剂
5.COX 1与COX 2抑制剂的表格形式
6。摘要 - COX 1 vs COX 2抑制剂

什么是Cox 1抑制剂?

COX 1 inhibitor is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase-1 enzyme. This enzyme is constitutively expressed in most tissues. Cyclooxygenase-1 (COX 1) isoform normally produces cytoprotective前列腺素. This enzyme is present in tissues, including gastrointestinal tract mucosa, kidneys, and platelets. Cyclooxygenase-1 isoform maintains the normal lining of the stomach and intestines. This isoform also protects the stomach from digestive juices. Moreover, Cyclooxygenase-1 isoform is involved in kidney and platelet function. Cyclooxygenase-1 enzyme produces prostaglandins that contribute to pain, fever, and inflammation. Therefore, COX 1 inhibitor is used to inhibit cyclooxygenase-1 isoform. Since the main role of cyclooxygenase-1 is to protect the stomach and intestine and contribute to blood clotting, the use of COX 1 inhibitor drugs can lead to unwanted side effects.

Traditional non-steroidal anti-inflammatory drugs such as ibuprofen, aspirin, and naproxen are inhibitors of both COX 1 and COX 2 isoforms as they are non-selective in their action. Traditional non-steroidal anti-inflammatory drugs are used to treat conditions like arthritis. Modern selective COX 1 inhibitors selectively inhibit only COX 1 isoform. Some examples of modern selective COX 1 inhibitors include ketorolac, flurbiprofen, ketoprofen, indomethacin, tolmetin, piroxicam, and meclofenamate. However, the inhibition of the COX 1 isoform can lead to side effects such as gastrointestinal ulcers and uncontrolled bleeding.

什么是Cox 2抑制剂?

COX 2抑制剂是一种非甾体类抗炎药，可抑制在炎症区域表达的环氧酶-2酶。选择性COX 2抑制剂具有笨重的侧链，该链链太大，无法定向进入环氧合酶-1酶的结合位点。但是它们能够对齐并与环氧合酶-2同工型结合。环氧酶-2酶在维持血管完整性中起主要作用。

环氧酶-2同工型的抑制导致内皮细胞的血管舒张前列腺素的产生降低。然而，由于成熟血小板上存在COX 2同工型，COX抑制剂不会抑制血小板的血栓烷。此外，Cox抑制剂被认为是增加心肌梗塞，充血性心力衰竭，中风，肺和全身性高血压的风险增加的因素。一些例子包括Cox 2抑制剂，包括苏氏酸，双氯芬酸，塞来昔布，Meloxicam，Etodolac等。

COX 1和COX 2抑制剂之间有什么相似之处？

• COX 1 inhibitor and COX 2 inhibitor are two non-steroidal anti-inflammatory drugs.
• They are involved in the inhibition of cyclooxygenase 1 (COX 1) and cyclooxygenase 2 (COX 2) enzymes that produce prostaglandins.
• COX 1和COX 2抑制剂都会引起严重的副作用。
• COX 1 and COX 2 inhibitors are selective in action than traditional non-steroidal anti-inflammatory drugs.

COX 1和COX 2抑制剂有什么区别?

COX 1抑制剂是一种非甾体类抗炎药，抑制环氧酶-1酶，在大多数组织中组成型表达，而Cox 2抑制剂是一种非甾体类抗炎性药物，可抑制环氧酶-2 enzyme，该药物抑制环氧酶在炎症区域表示。因此，这是COX 1和COX 2抑制剂之间的关键差异。此外，COX 1抑制剂的副作用包括胃肠道溃疡和不受控制的出血，而COX 2抑制剂的副作用包括发展心肌梗塞，充血性心力衰竭，中风，肺和全身性高血压。

The below infographic presents the differences between COX 1 and COX 2 inhibitors in tabular form for side by side comparison.

摘要 - COX 1 vs COX 2抑制剂

COX 1 inhibitor and COX 2 inhibitor are two non-steroidal anti-inflammatory drugs. They are selective than traditional non-steroidal anti-inflammatory drugs such as ibuprofen, aspirin, and naproxen. COX 1 inhibitor is a drug that inhibits cyclooxygenase-1 enzyme. COX 2 inhibitor is a drug that inhibits cyclooxygenase-2. So, this is the key difference between COX 1 inhibitor and COX 2 inhibitor.

Reference:

1.“环氧合酶1抑制剂”。概述| ScienceDirect主题。
2. Annette（Gbemudu）Ogbru，PharmD。“COX-2 Inhibitors: Drug List, Uses, Side Effects, Interactions.” RxList, 8 Apr. 2021.

Image Courtesy:

1.“”Flurbiprofen in COX-2” Ppruks - 通过Commons Wikimedia自己的作品（CC0）
2. “Etoricoxib molecule spacefill” By Jynto (more from this user) – Own work. created with Discovery Studio Visualizer. (CC0) via Commons Wikimedia