Difference Between Prostaglandins and Leukotrienes

Thekey difference在前列腺素和白细胞之间是prostaglandins are produced by all cell types and all parts of the body that deal with injury and illness while leukotrienes are produced byleukocytes.

Eicosanoids are a family of bioactive lipid mediators. They are oxygenated 20-carbon fatty acids synthesized from dietary essential fatty acids. They participate in the regulation of an array of physiological and pathological responses. Moreover, they show potent inflammatory properties and help in the development and regulation of immunological and inflammatory responses. Prostaglandins and leukotrienes are two types of eicosanoids derived from arachidonic acid. Prostaglandins enhance the vascular permeability effects ofhistamineand bradykinin while leukotrienes mediate leukocyte accumulation duringacute inflammation.

内容

1.Overview and Key Difference
2.What are Prostaglandins
3.什么是白细胞
4.Similarities Between Prostaglandins and Leukotrienes
5.Side by Side Comparison – Prostaglandins vs Leukotrienes in Tabular Form
6.概括

什么是前列腺素？

Prostaglandins are a family of 20 carbon fatty acid eicosanoids. They are synthesized from arachidonic acid via cyclooxygenase at the sites of tissues damage or infection. Therefore, they are produced in all most all cell types and all parts of the body that deal with injury and illness. They are widely distributed within the body.

Difference Between Prostaglandins and Leukotrienes

Figure 01: Prostaglandin

However, prostaglandins are short-lived. They break down quickly. Prostaglandins control processes like inflammation, blood flow, blood clot formation and induction of labour in our body. Moreover, prostaglandins regulate the female reproductive system. They function by acting on specific receptors.

什么是白细胞?

Leukotrienes are another group eicosanoids that act as inflammatory mediators. Leukocytes such asmast cells,嗜酸性粒细胞, etc. produce leukotrienes by the oxidation of arachidonic acid. An enzyme called arachidonate 5-lipoxygenase catalyzes the synthesis process. The production of leukotrienes is usually accompanied by the production of histamine and prostaglandins.

Key Difference - Prostaglandins vs Leukotrienes

Figure 02: Leukotrienes

白细胞有两种类型。第一组白细胞在炎症取决于中性粒细胞的条件下作用。第二组白细胞对嗜酸性粒细胞和肥大细胞诱导的哮喘的支气管收缩作用。总体而言，白细胞是炎症反应和引起哮喘和过敏反应的重要药物。

前列腺素和白三烯之间有什么相似之处？

Prostaglandins and leukotrienes are inflammatory mediators.
They are eicosanoids.
They are produced from arachidonic acid.
白细胞的产生通常伴随组胺和前列腺素的产生。
Both types are involved in the development and regulation of immunological and inflammatory responses.

前列腺素和白三烯有什么区别？

Prostaglandins and leukotrienes are two groups of eicosanoids. Prostaglandins are produced by almost all cell types of the body while leukotrienes are produced by leukocytes. So, this is the key difference between prostaglandins and leukotrienes. Furthermore, prostaglandins are generated by the phospholipase A2/cyclooxygenase pathway from arachidonic acids, while leukotrienes are generated by the 5-lipoxygenase pathway from arachidonic acid.

Moreover, functionally, prostaglandins are important in vasodilation, inflammation and regulation of the contraction of smooth muscle tissue. In contrast, leukotrienes are involved in asthmatic and allergic reactions and act to sustain inflammatory reactions.

下面的信息图总结了前列腺素和白三烯之间的差异。

摘要 - 前列腺素vs白细胞

前列腺素和白细胞是四种类型的eicosanoids中的两种，它们是生物活性脂质介质。它们是由称为花生四烯酸的20碳多不饱和脂肪酸产生的。前列腺素是由我们体内所有类型的细胞产生的。相比之下，白细胞仅由白细胞产生。前列腺素可以扩张血管，调节炎症，会引起疼痛并诱发发烧。白三烯有助于哮喘，关节炎和过敏反应等疾病。因此，这总结了前列腺素和白三烯之间的差异。