这关键区别paget病和湿疹之间Paget’s disease is a focal disorder of bone remodeling, and eczema is an炎症condition of the skin characterized by groups of vesicularlesions具有变化程度的渗出量和缩放。
Paget病发生是由于某些基因的突变,例如核因子Kappa B,Secestosom P62和骨蛋白蛋白蛋白蛋白。另一方面,湿疹是由于安装了不同的反应而发生的allergens。发病机理的这种差异是两种疾病之间的主要差异。
CONTENTS
1。概述和关键差异
2。What is Paget’s Disease
3。什么是湿疹
4。Side by Side Comparison – Paget’s Disease vs Eczema in Tabular Form
5.Summary
什么是paget病?
Paget病是一种骨骼重塑的局灶性疾病。Initially, there is an increase in the bone resorption which is followed by a compensatory increase in the new bone formation. The result is the formation of structurally abnormal bone tissue.
People above 40 years of age are the usual victims of this condition, and there is a female preponderance. A higher prevalence has been observed in the European region. The involvement of several genes including nuclear factor kappa B, sequestosome p62, and osteoprotegerin has been implicated in the pathogenesis of the Paget’s disease.
Clinical Features
- 骨痛(主要在脊柱或骨盆中)
- Joint pain
- 骨畸形
- Neurological deficits because of the compression of cranial nerves mainly II, V, VII and VIII. Spinal stenosis and hydrocephalus can also happen.
- 高输出心力衰竭
- Pathological fractures
- 有时也可能发生成骨的肉瘤
调查
- X-ray – lytic lesions can be seen in the initial stage followed by a mixed phase and in the most advanced stage, abnormal bone formation can be identified.
- Isotope bone scan can be used to identify the extent of bone involvement
- 血清碱性磷酸酶水平随尿羟基丙烯水平而增加
Management
Bisphosphonates are the drug of choice in the management. The drug course is given intermittently depending on the serum alkaline phosphatase level and urinary hydroxyproline level. Asymptomatic patients with lesions identified in the radiological images if there is a potential risk of getting complications such as fractures of the weight-bearing long bones.
什么是湿疹?
湿疹是皮肤的炎症状况,其特征是一组囊泡病变,具有变化的渗出液和缩放度。Vesicles form as a result of the edema in between the epidermal cells. There are different types of eczema. Atopic dermatitis is one of them. The other varieties of eczema include,
- 接触性皮炎
接触性皮炎是由外源性剂沉淀的皮炎,通常是一种化学物质。镍敏感性是最常见的接触过敏,影响了10%的女性和1%的男性。
Etiopathogenesis
Irritants than allergens mostly cause contact dermatitis. However, the clinical appearances of both seem to be similar. Allergic contact dermatitis is caused immunologically by type Ⅳ hypersensitivity reactions. The mechanism thorugh which irritants cause dermatitis varies, but the direct noxious effect on the skin’s barrier function is the most frequently observed mechanism.
这most important irritants associated with contact dermatitis are;
- Abrasives ex: frictional irritancy
- Water and other fluids
- Chemicals ex: acids and alkalis
- 溶剂和洗涤剂
大多数这些刺激物是慢性的影响,but a strong irritant causing necrosis of epidermal cells may produce a reaction within few hours. Dermatitis can be induced by repetitive and cumulative exposure to water abrasives and chemicals over several months or years. This commonly occurs in hands. Susceptibility of individuals with a history of atopic eczema to irritants, to have contact dermatitis is high.
临床表现
Dermatitis can affect any part of the body. When dermatitis appears at a particular site, that suggests a contact with a certain object. When a patient having a history of Nickel allergy presents with eczema on the wrist, it suggests an allergic response to a watch strap buckle. It is easy to list the possible causes by knowing the patient’s occupation, hobbies, past history and use of cosmetics or medicaments. Environmental sources of some common allergens are given below.
通过次要“自动敏化”扩散,有时会广泛化过敏性接触性皮炎。照片接触反应是由紫外线辐射局部或全身施用的药物激活引起的。
Management
这management of contact dermatitis is not always easy. This is due to many overlapping factors. The overriding objective is the identification of any offending allergen or irritant. Patch testing is useful in dermatitis of the face, hands, and feet since it helps to identify any allergens involved. The exclusion of an offending allergen from the environment is desirable to clear dermatitis.
但有些过敏原如镍或树脂difficult to eliminate. Moreover, it is impossible to exclude irritants. Contact of irritants during certain occupations is inevitable. Protective clothing should be worn, adequate washing and drying facilities should be provided in order to minimize the contact with such irritants. Secondary to avoidance measures, patients can use topical steroids in contact dermatitis.
Eczema herpeticum
特应性皮炎的儿童患疱疹病毒感染的风险更高。这可能是威胁生命的,
Nummular eczema
Coin-shaped lesions appear on the trunk and the legs
Paget’s disease of the breast
Eczema around the nipples and areola of women, which is most often due to an underlying carcinoma
地衣单纯形
This is characterized by the formation of a localized area of lichens due to rubbing
Neurodermatitis
皮肤的普遍瘙痒和干燥
Asteatotic dermatitis
Occurs in elderly people particularly on the legs
Stasis eczema
这些出现在静脉充血的区域
paget病和湿疹有什么相似之处?
- Both are diseases of the musculoskeletal system
What is the Difference Between Paget’s Disease and Eczema?
Paget病是一种骨骼重塑的局灶性疾病。湿疹是皮肤的炎症状况,其特征是一组囊泡病变,具有变化的渗出液和缩放度。遗传突变被认为是paget病的原因,而湿疹是由于过敏反应。
Clinical Features
Paget的临床特征包括骨痛(主要在脊柱或骨盆中),关节疼痛,骨骼畸形,神经系统缺陷,因为颅神经主要是II,V,VII和VIII。脊柱狭窄和脑积水也可能发生,高输出心力衰竭,病理骨折以及有时会发生成骨肉瘤。
Eczema can affect any part of the body. When dermatitis appears at a particular site, that suggests a contact with a certain object. When a patient having a history of Nickel allergy presents with eczema on the wrist it suggests an allergic response to a watch strap buckle. Therefore, it is easy to list the possible causes by knowing the patient’s occupation, hobbies, past history and use of cosmetics or medicaments.
调查
关于paget病;X射线 - 裂解病变可以在初始阶段看到混合阶段,在最先进的阶段,可以鉴定出异常的骨形成,同位素骨扫描可用于识别骨骼受累的程度和血清碱磷酸酶水平随尿羟基丙烯水平而增加。对于湿疹,皮肤刺测试可用于鉴定潜在的过敏原。
治疗和管理
对于Paget氏病,双膦酸盐是管理中首选的药物。根据血清碱性磷酸酶水平和尿羟基丙烯水平,该药物的间歇性给予间歇性。由于在任何一种情况下可能涉及的许多且经常重叠的因素,因此湿疹的管理并不总是那么容易。补丁测试在脸部,手和脚的皮肤炎中特别有用。它有助于识别任何涉及的过敏原。此外,在清除皮炎方面,应排除在环境之外的冒犯过敏原。
摘要 - Paget病与湿疹
Paget’s disease is a focal disorder of bone remodeling whereas eczema is an inflammatory condition of the skin characterized by groups of vesicular lesions with a variable degree of exudates and scaling. Mutations in certain genes are the cause of the Paget’s disease. Eczema, on the other hand, occurs because of hypersensitivity reactions mounted against various allergens. This is the main difference between Paget’s Disease and Eczema.
参考:
1. Parveen Kumar。Kumar and Clark’s Clinical Medicine。由迈克尔·克拉克(Michael L Clark)编辑,第八版。
图片提供:
1。’Paget’s disease in vertebra on CT’By James Heilman(CC BY-SA 4.0)通过下议院维基梅迪亚
2。’4149275665′ by Marek Isalski(CC BY-SA 2.0)通过Flickr
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