肌肉营养不良和肌无力的肌无力之间的差异

关键区别 - 肌肉营养不良与肌无力

Body movements happen as a result of the collaboration between muscles and neuronal mechanisms that control them. Therefore, any failure or collapse of these components can severely impair the mobility of a person. In myasthenia gravis and muscular dystrophy, there are such limitations to the body’s ability to move. A progressive loss of muscle mass and the resultant loss of muscle strength are the hallmark features of muscular dystrophy. On the other hand, myasthenia gravis is an自身免疫性障碍characterized by the production of抗体that block the transmission of impulses across the neuromuscular junction. The关键区别在两种障碍之间，在肌无力的肌无力中，问题是在神经肌肉连接处的水平，但在肌肉营养不良中，病变在肌肉中。

CONTENTS

1。概述和关键差异
2。What is Muscular Dystrophy
3。什么是肌无力
4。Similarities Between Muscular Dystrophy and Myasthenia Gravis
5。并排比较 - 表格形式的肌肉营养不良与肌无力
6。Summary

什么是肌肉营养不良？

A progressive loss of muscle mass and the resultant loss of muscle strength are the hallmark features of muscle dystrophy.基因突变特别是在肌营养不良蛋白基因中，被认为是这种疾病的原因。有许多肌肉营养不良的多种肌营养不良，其中杜钦肌营养不良是最常见的。

症状和体征

Early symptoms include:

• 肌肉疼痛僵硬
• 劳累困难
• 涉水步态
• 不平衡
• 学习困难

晚期表现包括：

• 由于的弱点resp呼吸道损伤iratory muscles
• 不动
• Cardiac problems
• 缩短肌肉和肌腱

调查s

通常，进行肌肉活检是为了识别肌肉营养不良的病理变异。

Treatment

• 没有确定的治疗，仅进行症状管理
• 基因疗法作为治愈肌营养不良的治疗
• Drugs such ascorticosteroids被给予控制炎症
• ACE抑制剂和β受体阻滞剂可用于管理心脏并发症
• 物理疗法可以作为药物疗法的辅助药物提供

什么是肌无力的Gravis？

肌无力重症是一种自身免疫性疾病，其特征是产生抗体，可阻断脉冲传播整个神经肌肉连接。这些抗体与突触后ACH受体结合，从而阻止ACH在突触裂to those receptors. Women are five times more affected by this condition than males. There is a significant association with other autoimmune disorders such as类风湿关节炎，，，，SLE, and autoimmune thyroiditis. Concurrent thymic增生has been observed.

临床表现

• 近端肢体肌肉，眼外肌肉和鳞茎肌肉的弱点
• There are fatigability and fluctuation with regard to the muscle weakness
• No muscle pain
• Heart is not affected but the respiratory muscles can be affected
• 反射也很疲倦
• Diplopia, ptosis, and dysphagia

调查s

• 血清中的抗ACH受体抗体
• tensilon测试，施用了一剂edrophonium剂量，这会导致症状的短暂改善，持续约5分钟
• 成像研究
• ESR和CRP

Management

• 抗胆碱酯酶（例如吡ido虫）
• 可以将免疫抑制剂（例如皮质类固醇）提供给对抗胆碱酯酶不反应的患者
• 胸腺切除术
• 血浆置换
• 静脉内免疫球蛋白

What is the Similarity Between Muscular Dystrophy and Myasthenia Gravis?

• Both can impair mobility of the patient severely.

肌肉营养不良和重症肌无力有什么区别？

肌肉营养不良与肌无力
A progressive loss of muscle mass and the resultant loss of muscle strength are the hallmark features of muscle dystrophy.	肌无力重症是一种自身免疫性疾病，其特征是产生抗体，可阻断脉冲传播整个神经肌肉连接。
缺点
缺点is in the muscles	缺陷在神经肌肉连接处
临床表现
Early symptoms include: 肌肉疼痛僵硬 劳累困难 涉水步态 不平衡 学习困难 晚期表现包括： 由于的弱点resp呼吸道损伤iratory muscles 不动 Cardiac problems 缩短肌肉和肌腱	Clinical features are, · There is weakness of proximal limb muscles, extraocular muscles ,and bulbar muscles · There are fatigability and fluctuation with regard to the muscle weakness ·没有肌肉疼痛 ·心脏不受影响，但呼吸肌可能会受到影响 ·反射也可疲劳 · Diplopia, ptosis ,and dysphagia
调查
通常，进行肌肉活检是为了识别肌肉营养不良的病理变异。	怀疑重症肌无力时进行了调查。 ·血清中的抗ACH受体抗体 · Tensilon test where a dose of edrophonium is administered which gives rise to a transient improvement of the symptoms that lasts for about 5 minutes ·成像研究 ·ESR和CRP
Management
·没有确定的治疗，仅进行症状管理 ·基因疗法作为治愈肌营养不良的治疗 ·药物（例如皮质类固醇）用于控制炎症 ·ACE抑制剂和β受体阻滞剂可用于管理心脏并发症 · Physiotherapy can be provided as an adjuvant to the pharmacotherapy	· Administration of anticholinesterases such as pyridostigmine ·可以给予对抗胆碱酯酶反应的患者，例如皮质类固醇等免疫抑制剂 ·胸腺切除术 ·血浆置换 · Intravenous immunoglobulins

概括 -肌肉营养不良与肌无力

A progressive loss of muscle mass and the resultant loss of muscle strength are the hallmark features of muscle dystrophy whereas myasthenia gravis is an autoimmune disorder characterized by the production of antibodies that block the transmission of impulses across the neuromuscular junction. In muscular dystrophy, the defect is in the muscles but in myasthenia gravis, the defect is at the neuromuscular junction. This is the difference between the two disorders.

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参考：

1。Kumar, Vinay, Stanley Leonard Robbins, Ramzi S. Cotran, Abul K. Abbas, and Nelson Fausto. Robbins and Cotran pathologic basis of disease. 9th ed. Philadelphia, Pa: Elsevier Saunders, 2010. Print.

图片提供：

1.'Senator Stabenow会见父母项目的代表肌肉营养不良（32781281061）’参议员Stabenow（公共领域）通过下议院维基梅迪亚
2。’Ptosis myasthenia gravis’By Mohankumar Kurukumbi, Roger L Weir, Janaki Kalyanam, Mansoor Nasim, Annapurni Jayam-Trouth. – Rare association of thymoma, myasthenia gravis and sarcoidosis : a case report. Journal of Medical Case Reports. 2008;2:245. doi:10.1186/1752-1947-2-245,(CC BY 2.0)通过下议院维基梅迪亚