Difference Between Intragenic and Extragenic Suppressor Mutation

Thekey differencebetween intragenic and extragenic suppressor mutation is thatintragenic suppressor mutation is asuppressor mutation发生在同一基因内。相反，外部抑制突变是在不同基因中发生的突变。

突变是基因的核苷酸序列的改变。抑制突变是第二个突变，可抑制phenotypiceffect of the first mutation. Suppression mutation occurs at a site distinct from the first mutation. It can restore the original function of the mutated gene. There are two types of suppression mutations. They are intragenic suppression mutation and intergenic (extragenic) suppression mutations.

内容

1.Overview and Key Difference
2.What is Intragenic Suppressor Mutation
3.What is Extragenic Suppressor Mutation
4.Similarities Between Intragenic and Extragenic Suppressor Mutation
5.并排比较 - 表格形式的基因内抑制剂突变
6。概括

What is an Intragenic Suppressor Mutation?

Intragenic suppressor mutation is one of the two types of suppression mutation. As the name suggests, the suppressor lies within the same gene of the first mutation. Therefore, the second mutation occurs within the same gene to alleviate or reverse the original mutation’s phenotypic effect.

有几种机制发生了基因内抑制突变。它们包括相同位置的替代品，补偿性突变，剪接的改变以及通过顺式敲除占主导突变的逆转。在大多数基因内抑制突变中，该突变以同一三重核苷酸的不同核苷酸进行，以代码子编码原始氨基酸。

What is an Extragenic Suppressor Mutation?

Extragenic suppressor mutation or intergenic suppressor mutation is the second type of suppression mutation. In this type of mutation, the suppressor lies in a different gene compared to the gene of the first mutation. Extragenic suppression mutation can occur in various ways such as alterations in splicing, translation or nonsense-mediated decay. Moreover, they can occur via bypass, dosage effects, product interaction, or removal of toxic products. Most extragenic suppressor mutations result in a product which can compensate for the dysfunction in the first mutation. Extragenic suppressor mutations are useful in identifying and studying interactions between molecules like proteins.

What are the Similarities Between Intragenic and Extragenic Suppressor Mutation?

• Intragenic and extragenic suppressor mutations are two types of suppression mutations.
• They are second mutations which occur at a site distinct from the location of the first mutation.
• Both types of mutations suppress the phenotypic effect of the first mutation.
• In other words, both types of mutations are able to restore the phenotype seen prior to the original background mutation.

What is the Difference Between Intragenic and Extragenic Suppressor Mutation?

Suppressor mutation is a second mutation that restores the function of a gene lost by a first mutation. A suppressor mutation that occurs within the same gene is known as intragenic suppressor mutation while a mutation which occurs in a different gene is known as extragenic suppressor mutation. So, this is the key difference between intragenic and extragenic suppressor mutation.

Below is a summary of the difference between intragenic and extragenic suppressor mutation in tabular form.

概括– Intragenic vs Extragenic Suppressor Mutation

Suppression mutations are second mutations that correct the original function of a mutated gene. Intragenic suppressor mutation occurs within the same gene where the original mutation occurred and restores the wild type phenotype. Extragenic suppressor mutation takes place in a different gene and corrects the phenotypic effect of the first mutation. Thus, this is the key difference between intragenic and extragenic suppressor mutation.

Reference:

“遗传抑制*。”。蠕虫标题图像，Available here.
“抑制突变。”维基百科,维基一块tion, 12 Dec. 2020,Available here.

Image Courtesy:

1. “Oncogene and tumour suppressor gene” By Philippe Hupé – Emmanuel Barillot, Laurence Calzone, Philippe Hupé, Jean-Philippe Vert, Andrei Zinovyev, Computational Systems Biology of Cancer Chapman & Hall/CRC Mathematical & Computational Biology, 2012,(CC BY-SA 3.0)viaCommons Wikimedia