Difference Between Heme and Hemin

Thekey differencebetween heme and hemin is that血红素包含ferrousion, whereas hemin contains ferric ion.

Heme and hemin areporphyrinprotein molecules. These are杂环高分子有机化合物,我们可以的名字。

CONTENTS

1.Overview and Key Difference
2.What is Heme
3.什么是hemin
4.Similarities Between Heme and Hemin
5.Side by Side Comparison – Heme vs Hemin in Tabular Form
6.概括

What is Heme?

Heme is a biochemical substance that is necessary to bind oxygen in the bloodstream. This substance is produced from biosynthesis in both the bone marrow and the liver. In the field of microbiology, the term heme refers to a coordination complex containing an iron ion coordinated to a porphyrin that acts as a tetradentate ligand and to one or two axial ligands.

通常，包括血红素在内的血蛋白具有许多生物学功能，例如双原子气体的运输，化学催化，双原子气体检测和电子转移。血红素铁充当电子转移或氧化还原化学期间电子的来源或下沉。

There are different types of heme molecules such as heme A, heme B, heme C, and heme O. These molecules have different chemical formulas and different functional groups as well. Among these types, heme B is the most common form, but heme A and heme C are also equally important. In addition, there can be some rare forms of heme as well, which include heme I, which is a derivative of heme B that covalently attaches to the protein residue of lactoperoxidase. Similarly, heme M is derived from heme B, which tends to covalently bond to the active site of myeloperoxidase. Heme D is also a derivative of heme B, consisting of a propionic acid side chain at the C-6 position.

When considering the production of heme proteins, the enzymatic pathway of heme production is named the porphyrin synthesis, and here all the intermediates are tetrapyrroles that are chemically named as porphyrins.

The degradation of heme protein molecules begins inside the macrophages of the spleen, which can remove old and damaged erythrocytes from the circulation.

什么是hemin

Hemin is a type of porphyrin containing chlorine, and it can form from heme groups, including heme B. This compounds’ structure is named protoporphyrin IX, and it contains a ferric iron ion containing a coordinating chloride ligand. In chemical terms, the hemin molecule is different from heme-compound hematin because of the chloride ion in hemin in the place of the coordinating hydroxide ion in hematin.

This substance is produced in our human body endogenously, e.g. during the turnover of old red blood cells. However, this substance can also form as a result of hemolysis or vascular injury. Moreover, several proteins in human blood also bind to hemin, e.g. hemopexin and serum albumin.

血红素和Hemin之间有什么相似之处？

• Heme and hemin are organic compounds.
• Both are coordination complexes.
• They contain iron ions.

What is the Difference Between Heme and Hemin?

血红素和血红素是卟啉蛋白分子。血红素是一种生化物质，是在血液中结合氧气所必需的，而Hemin是一种含有血红素组的卟啉的卟啉，包括血红素B。血红素和Hemin之间的关键差异是血红素含有纤毛离子，而hemin hemin hemin hemin包含铁离子。此外，血红素不含氯化原子，而Hemin含有氯化原子。

Below is a summary of the difference between heme and hemin in tabular form.

概括– Heme vs Hemin

血红素和血红素是卟啉蛋白分子。The key difference between heme and hemin is that heme contains ferrous ion, whereas hemin contains ferric ion. Furthermore, hemin molecules contain chloride atoms in the chemical structure, whereas heme does not contain chloride atoms.

Reference:

1.诺德奎斯特，理查德。“主题。”Thinkco，2021年2月16日，Available here.

Image Courtesy:

1. “Mboxygenation” By Smokefoot – Own work(CC BY-SA 4.0)viaCommons Wikimedia
2. “Hemin edit1” By Impz – Own work(CC BY 3.0)viaCommons Wikimedia