Folate vs Folic Acid
Chemically, both folic acid and folate might sound more or less the same as folate is the ionized form of the acid after losing aprotonmaking it a carboxylateanion。However, this distinction between folic acid and folate is more of a biological nature. Here both these are referred to as a nutrient and more correctly a dietary supplement as they are forms of water soluble vitamin B. It is essential to maintain the correct amount of B vitamin in the body as it is a vital vitamin for many bodily functions. But humans cannot synthesize folate within the body and, therefore, needs to be taken through diet, to meet the daily requirements. The words folic acid and folate are derived from the Latin word ‘folium’ which means ‘leaf’.
Folic Acid
Folic acid does not naturally occur in food. Other supplements are often used when the required amounts of folate in the body is not obtained naturally through food. Folic acid is one such type, but it is a synthetic form, and the way folic acid is metabolized is quite different from the way folate is metabolized in the dietary system within the body.
In order to enter the main folate metabolic cycle, folate or any other type of supplement used (i.e. folic acid) should be converted into ‘tetrahydrofolate’ (THF). Therefore to obtain this product, folic acid undergoes an initial reduction (addition of electrons/H atoms) followed by a methylation step (attaching a ‘methyl’ group) in theliver, and thereafter the conversion to THF requires an additional酶called ‘dihydrofolate reductase’. The proper activity of this enzyme is essential in order to breakdown folic acid efficiently and to produce the required amount of THF in order to meet the body’s vitamin B requirement.
另一方面,酶的活性较小,或者较高的叶酸消耗超过有限的叶酸会导致无代谢的叶酸收集到血液中,并可能导致癌症。此外,由于存在未代谢的叶酸,因此需要掩盖叶酸,最终可能会遭受维生素B缺乏症的困扰。这就是为什么最好从食物中自然获得叶酸,而不是过度融合补充剂的原因。
Therefore, folic acid itself is not biologically active; it becomes biologically important only after the conversion of tetrahydrofolate and other derivatives into dihydrofolic acid in the liver.
Folate
Folate is the general term used for a group of water soluble B vitamins and refers to various THF derivatives naturally found in food. The best and the healthiest way to fulfill one’s folate requirement is through natural foods as other forms of dietary folate supplements are paired with many health risks when taken too much. But the adequate consumption of folate rich natural food is essential for health. The human body requires folate to synthesize and repair脱氧核糖核酸, to aid rapidcell divisionand growth especially during infancy and pregnancy. Folate is also required for the production of healthy红细胞为了防止贫血条件。与叶酸不同,叶酸自然代谢为THFsmall intestineand enters the metabolic cycle faster with fewer enzyme dependencies than folic acid.
Sources for folate rich food includes leafy vegetables (spinach,broccoli,lettuce), fruits (bananas, lemons),cereals, okra, asparagus, tomato juice,mushroomsetc.
What is the difference between Folic Acid and Folate?
• Folate is a form of vitamin B naturally occurring in food while folic acid is the synthetic form of this vitamin.
• Themetabolismof folic acid in the human body requires the action of an extra enzyme called ‘dihydrofolate reductase’ in the liver, whereas folate enters the metabolism cycle faster.
• Higher consumption of folic acid (through supplements) may lead to cancer, whereas there’s no such health hazard associated with the consumption of folate through natural foods.
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