What is the Difference Between AstraZeneca and Pfizer

Thekey differencebetween AstraZeneca and Pfizer is that阿斯利康是一个DNA vaccineused against新冠肺炎disease, while Pfizer is anmRNA vaccineused against COVID19 disease.

COVID19 is a serious infectious disease that is caused by a new新冠病毒. People who suffer from this virus experience mild to moderate respiratory illness and recover without any special treatment. Older people and those who suffer from underlying medical conditions like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illnesses. The mass vaccination process for COVID 19 disease started in 2020. Currently, four vaccines are authorized and recommended by the WHO: AstraZeneca, Pfizer, Moderna, and Janssen (J&J).

内容

1.Overview and Key Difference
2.What is AstraZeneca
3.What is Pfizer
4.Similarities Between AstraZeneca and Pfizer
5.并排比较 - 表格形式的阿斯利康与辉瑞
6.概括

什么是阿斯利康？

阿斯利康是一种针对Covid 19疾病的DNA疫苗。阿斯利康公司（Astrazeneca Company）与牛津大学合作，于2020年制造这种疫苗。它显示出90％的抗Covid 19疾病疗效。通过这种疫苗，将遗传指示提供给细胞，以使Covid19病毒的尖峰蛋白刺激人类的免疫反应。在这种疫苗中，DNA实际上用作触发细胞制成峰值蛋白的遗传指导。阿斯利康疫苗使用另一种方法将其遗传指导引入细胞。因此，这种疫苗使用adenovirus, which normally infects chimpanzee as a vector to deliver DNA into the cell.

The genetic instructions are inserted into the adenovirus vector for making the SARS COV2 spike protein. The adenovirus infects the human cell and delivers the DNA into the cytoplasm of the human cell. The cell recognizes the DNA material and places it in the nucleus. The ribosomes transcribe the instruction set to make the spike protein. Then the spike protein causes the immune response to make antibodies and activates T cells, B cells, etc.

What is Pfizer?

辉瑞是一种针对Covid-19疾病的mRNA疫苗。这种疫苗是由辉瑞-Biontech公司于2020年开产的。它也称为“ Tozinameran或Bnt162b2”。该疫苗已批准为12岁以上的人。加拿大卫生部在2020年12月首次授权这种疫苗。该疫苗使用人类细胞读取的mRNA来生产蛋白质。为了保护mRNA疫苗，辉瑞-biontech将mRNA包裹在脂质纳米颗粒制成的油泡中，然后再递送到细胞。

The cell reads the mRNA sequence and builds spike proteins. Then the mRNA from the vaccine is eventually destroyed by the cell. Later, these spike proteins are recognized by the immune system. This causes immune responses (antibody production and T cell and B cell activation) and protection from COVID19 infection in future. Pfizer mRNA vaccine has a 95% efficacy. Furthermore, this vaccine should be stored in an ultra-cold freezer between -80 °C and -60 °C temperatures.

What are the Similarities Between AstraZeneca and Pfizer?

• 两者都是疫苗的类型。
• They are both used against the COVID19 virus.
• Both have approximately 90% efficacy.
• 这些疫苗使用诸如DNA或遗传物质mRNA.
• They show side effects.

阿斯利康和辉瑞之间有什么区别？

阿斯利康是一个DNA vaccine used against COVID19 disease. Pfizer is an mRNA vaccine used against COVID19 disease. So, this is the key difference between AstraZeneca and Pfizer. Furthermore, AstraZeneca can be stored in normal refrigerator temperatures, such as between 36 °F and 46 °F. In contrast, Pfizer should be stored in sub-zero temperatures, such as between -4 °F and -94 °F.

下面的信息图表列出了阿斯利康和辉瑞疫苗之间的差异，以便并排比较。

概括– AstraZeneca vs Pfizer

There are many vaccines simultaneously in the pipeline for COVID 19 infectious disease. AstraZeneca and Pfizer are two vaccines that are listed in the WHO emergency use listing (EUL). AstraZeneca is a DNA vaccine, while Pfizer is an mRNA vaccine used against COVID19 disease. So, this is the summary of what is the difference between AstraZeneca and Pfizer.

Reference:

1. Smith, Jake. “Here’s How the AstraZeneca COVID-19 Vaccine Compares to Those Available in the U.S.” Prevention, 3 May 2021,Available here.
2. “Pfizer-BioNTech COVID-19 Vaccine Overview and Safety.” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention,Available here.

Image Courtesy:

1. RWENDLAND的“ Covid-19-2019 Astrazeneca疫苗小瓶和NHS记录卡” - 自己的工作(CC BY-SA 4.0)viaCommons Wikimedia
2. “Pfizer-Biontech Covid-19疫苗（2020）D” By U.S. Secretary of Defense –（CC由2.0）viaCommons Wikimedia