两性霉素B和脂质体两性霉素B之间有什么区别| Compare the Difference Between Similar Terms

这两性霉素B和脂质体两性霉素B之间的关键区别is that amphotericin B is an antifungal medication that contains amphotericin B deoxycholate solution, while liposomal amphotericin B is an antifungal medication that consists of a unilamellar liposomal vesicle made up of a mixture of phosphhatidylcholine,胆固醇, and distearoyl phosphatidylglycerol in aqueous media that contains amphotericin B.

Antifungal medicines are used to treat fungal infections that commonly affect the skin, hair, and nails. The common fungal infections that are treated with antifungal medicines include癣, athlete’s foot, fungal nail infection, vaginal thrush, andthrush。两性霉素B和脂质体两性霉素B是两种常见的抗真菌药物。但是，一些真菌感染，例如aspergillosis，影响肺部和影响大脑的真菌脑膜炎，需要在医院中进行治疗。

1。概述和关键差异
2。什么是两性霉素B
3。What is Liposomal Amphotericin B
4。相似性 - 两性霉素B和脂质体两性霉素B
5。两性霉素B与脂质体两性霉素B的表格形式
6.Summary – Amphotericin B vs Liposomal Amphotericin B

什么是两性霉素B？

Amphotericin B is an antifungal medication that contains amphotericin B deoxycholate solution. Amphotericin B is used to treat fungal infections in neutropenic patients, crptococcal meningitis in HIV infection, fungal infection, and leishmaniasis. This original formulation uses sodium deoxycholate, which improves its solubility. Amphotericin B deoxycholate (ABD) is administrated intravenously. As the original formulation of amphotericin B, it is often referred to as conventional amphotericin B.

图01：两性霉素B

两性霉素B通过与固醇结合破坏真菌细胞壁的合成来发挥其抗真菌作用。这导致细胞壁中孔的形成，从而允许细胞成分泄漏。此外，在过去的40年中，两性霉素B脱氧胆酸盐一直是侵入性真菌感染的金标准。由于常规两性霉素B的肾脏毒性，广泛的研究导致了几种新的抗真菌剂的发展，包括两性霉素B，板谱唑唑和冰虫蛋白的脂质配方。

什么是脂质体两性霉素B？

脂质体两性霉素B是一种抗真菌药物，由一个单层脂质体囊泡组成，由磷脂酰胆碱，胆固醇和脱磷脂酰磷脂酰甘油的混合物组成，在水性培养基中的水性培养基中，含有含量素的配方均具有良好的效率。因此，脂质体制剂的肾脏毒性少于两性霉素B脱氧胆酸盐。此外，脂质体两性霉素B的相关反应较少。但是，脂质体两性霉素B比常规两性霉素B贵。这种抗真菌药物可用于治疗系统的真菌感染，隐球菌脑膜炎，内脏利什曼病，Candida aurisfungemia,组织胞浆菌病。

图02：脂质体两性霉素B

AmBisome (LAMB) is a liposomal formulation of amphotericin B that is normally introduced through injections. Furthermore, it was originally developed by Nexstar Pharmaceuticals and approved by the FDA in 1997. Liposomal amphotericin B is marketed by Gllead in Europe and licensed to Astellas Pharma for marketing in the United States and Sumitomo Pharmaceuticals in Japan.

两性霉素B和脂质体两性霉素B之间有什么相似之处？

两性霉素B和脂质体两性霉素B是两种常见的抗真菌药物。
两种抗真菌药物均含有两性毒素B作为主要抗真菌剂。
它们被静脉注射给患者。
两种抗真菌药物都具有相同的机制：通过与固醇结合来破坏真菌细胞壁的合成。

两性霉素B和脂质体两性霉素B有什么区别？

两性霉素B（原始）是一种含有两性霉素B脱氧乙酸溶液的抗真菌药物，而脂质体两性霉素B是一种抗真菌药物，由单层脂质体囊泡组成，由磷脂型脂质体囊泡组成，由磷脂型磷脂素，杂菌素和磷脂磷脂磷脂磷脂磷脂磷脂磷脂含量磷脂磷脂，两性霉素B.因此，这是两性霉素B和脂质体两性霉素B之间的关键差异。此外，两性霉素B的耐受性和更高的毒性比脂质体两性霉素B。

下面的信息图列出了两性霉素B和脂质体两性霉素B的差异，以并排比较。