Difference Between Zinc Citrate and Zinc Gluconate

Thekey differencebetween zinc citrate and zinc gluconate is that柠檬酸锌的母体化合物citric acidwhereas the parent compound of zinc gluconate is gluconic acid.

Zinc citrate and zinc gluconate are two forms of dietary supplements that we use to prevent zinc deficiency.Zincis an essential mineral that our body can easily absorb. Therefore, if we do not get enough amount of zinc, we may have to take these dietary supplements as directed by the doctor. Let us go into more details on these compounds.

1.Overview and Key Difference
2.What is Zinc Citrate
3.What is Zinc Gluconate
4.Side by Side Comparison – Zinc Citrate vs Zinc Gluconate in Tabular Form
5.Summary

What is Zinc Citrate?

Zinc citrate is the zinc salt of citric acid. The chemical formula of this compound is C₁₂H₁₀O₁₄Zn₃. Its molar mass is 574.3 g/mol. Therefore, this compound contains three zinc cations (Zn⁺²) associated with two citrate ions. This compound is well-known as a dietary supplement that is useful in preventing zinc deficiency. Typically, we take this orally as a capsule or as a tablet.

However, due to the presence of zinc, this may have a metallic taste. It is a side effect of the treatment. However, taking a small amount of beverage after taking the tablet can avoid this unusual taste. Moreover, this treatment may irritate the digestive tract, resulting in an upset stomach. Another important side effect is, we may get flu-like symptoms including fever, sore throat, chills, etc.

What is Zinc Gluconate?

Zinc gluconate is the zinc salt of gluconic acid. The chemical formula of this compound is C₁₂H₂₂O₁₄Zn. It has the molar mass, 455.68 g/mol. It contains one zinc cation (Zn⁺²) associated with two anions of gluconic acid. Moreover, it is a popular dietary supplement and a good source of zinc. We can find gluconic acid in natural sources, but for the preparation of the supplement, industries produce gluconic acid via the fermentation of glucose byAspergillus nigeror some species of fungi.

Difference Between Zinc Citrate and Zinc Gluconate

Figure 01: Zinc Gluconate Structure

More importantly, this compound is used to treat a common cold. We can use it in lozenges to treat the cold symptoms. When considering the side effects of this compound, anosmia (loss of smell) is a reported side effect. However, this compound is relatively safe than other zinc supplements.

What is the Difference Between Zinc Citrate and Zinc Gluconate?

Zinc citrate is the zinc salt of citric acid. The chemical formula is C₁₂H₁₀O₁₄Zn₃and the molar mass of is 574.3 g/mol. Also, the parent compound of this compound is citric acid. Whereas, the zinc gluconate is the zinc salt of gluconic acid. The chemical formula is C₁₂H₂₂O₁₄Zn and the molar mass of is 455.68 g/mol. Here, the parent compound is gluconic acid. Therefore, the key difference between zinc citrate and zinc gluconate is their respective parent compounds. Although Zinc citrate has many side effects including metallic taste, upset stomach, flu-like symptoms, etc. zinc gluconate has only a few side effects such as anosmia, hence it is relatively safe.

Summary – Zinc Citrate vs Zinc Gluconate

Zinc supplements are very important because zinc is an essential mineral. Therefore, zinc citrate and zinc gluconate are two forms of supplements. The difference between zinc citrate and zinc gluconate is that the parent compound of zinc citrate is citric acid whereas the parent compound of zinc gluconate is gluconic acid.

Reference:

1. “ZINC Citrate.” National Center for Biotechnology Information. PubChem Compound Database, U.S. National Library of Medicine.Available here
2.Uddin, Rae. “Zinc Citrate Side Effects.” LIVESTRONG.COM, Leaf Group, 14 Aug. 2017.Available here
3. “ZINC Gluconate.” National Center for Biotechnology Information. PubChem Compound Database, U.S. National Library of Medicine.Available here