硫胺素单硝酸盐和盐酸硫胺素之间的差异

Key Difference – Thiamine Mononitrate vs Thiamine Hydrochloride

硫胺素单硝酸盐和盐酸硫胺素都是硫胺素的来源（维生素B1）。硫胺素mononitrate is prepared from Thiamine hydrochloride by removing chloride ion and mixing the final product with a nitric acid.This is thekey difference在本文中将讨论硫胺素单硝酸盐和盐酸硫胺素之间的进一步差异

What is Thiamine Mononitrate?

硫胺素mononitrate (IUPAC name3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium nitrate) is defined by the CAS number 532-43-4 and the EINECS number 208-537-4. The molecular formula for Thiamine mononitrate is C₁₂H₁₇N₄OS.NO₃. The structural formula of Thiamine mononitrate is as follows.

硫胺素mononitrate is also known asmononitrate de thiamine, nitrate de thiamine. It is also known by the generic names of Thiamine such asantiberiberi factorandantiberiberi vitamin.

硫胺素mononitrate is a stable nitrate salt, which occurs as a white crystalline powder with a faint characteristic odor and bitter taste. It is prepared from Thiamine hydrochloride and is considered as nutritional additive. It has a shelf life of 36 months at 25°C.

硫胺素mononitrate is used to treat beriberi, general malnutrition, and malabsorption. It is the source which used in food fortification. Thiamine mononitrate is generally recognized as safe (GRAS) as per the US Food And Drug Administration (FDA). But Thiamine mononitrate has the potential to elicit mild to severe allergic reactions as it is a synthetic compound.

What is Thiamine Hydrochloride?

硫胺素hydrochloride (IUPAC name 3-[(4-amino-2-methylpyrimidin-5-yl)methyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride hydrochloride) is identified by the CAS number 67-03-8, the EINECS number 200-641-8 and the FLAVIS number 16027. The molecular formula for Thiamine hydrochloride is C₁₂H₁₇N₄OS.CL.HCl。盐酸硫胺素的结构公式如下所示。

硫胺素盐酸盐是硫胺素的盐酸盐。硫胺素盐酸盐是白色或几乎白色的无味粉末。它是有氧代谢，细胞生长，神经冲动和乙酰胆碱合成的必不可少的维生素。它被认为是一种营养添加剂，在25°C的保质期为36个月。

What is the difference between Thiamine Mononitrate and Thiamine Hydrochloride?

Characteristics of Thiamine Mononitrate and Thiamine Hydrochloride

Water Absorption:

硫胺素mononitrate:硫胺素单硝酸盐没有吸湿性。

盐酸硫胺素：硫胺素hydrochloride is hygroscopic.

Stability:

硫胺素mononitrate:硫胺素mononitrate is more stable than Thiamine hydrochloride.

盐酸硫胺素：硫胺素hydrochloride is less stable than Thiamine mononitrate.

Molecular Weight:

硫胺素mononitrate:硫胺素mononitrate has a molecular weight of 327.36.

盐酸硫胺素：硫胺素hydrochloride has a molecular weight of 337.3.

Melting Point:

硫胺素mononitrate:硫胺素mononitrate has a melting point of 198°C.

盐酸硫胺素：硫胺素hydrochloride has a melting point of 248-250 °C.

Density:

硫胺素mononitrate:硫胺素单硝酸盐的密度为0.35 g/ml。

盐酸硫胺素：硫胺素盐酸的密度为0.4 g/ml。

Manufacturing Process:

硫胺素mononitrate:硫胺素mononitrate is obtained from Thiamine hydrochloride

盐酸硫胺素：硫胺素hydrochloride is obtained by the use of an ion exchange resin from Thiamine sulfate

Purity Criteria:

硫胺素mononitrate:硫胺素mononitrate is >97

盐酸硫胺素：硫胺素hydrochloride is >93.5

Reference

硫胺素[Online]. Available: https://en.wikipedia.org/wiki/Thiamine.

硫胺素mononitrate[Online]. Available: https://en.wikipedia.org/wiki/Thiamine_mononitrate.

EUROPEAN FOOD SAFTY AUTHORITY, I. 2011. Scientific Opinion.EFSA Journal,9,8

Image Courtesy:

“Thiamine mononitrate” By WildCation – Own work(CC BY-SA 4.0)viaCommons Wikimedia

“Thiamin” By NEUROtiker – Own work (Public Domain) viaCommons Wikimedia