Thekey differencebetween synthesis and retrosynthesis is that合成是organic compounds, whereas retrosynthesis is the technique solving problems regarding organic synthesis.
尽管术语的合成和逆合合成听起来相似,但它们是表达两种不同含义的两个不同术语。However, there is a relationship between them as well; retrosynthesis simply explains synthesis. In this article, we are using the term synthesis to explain the specific branch of chemical synthesis which involves organic synthesis. The production of a certain compound may have different possible routes of synthesis and we can determine the suitable route by comparing all the routes using retrosynthesis.
内容
1.Overview and Key Difference
2.什么是综合
3.What is Retrosynthesis
4.并排比较 - 综合与表格的回合合成
5。概括
什么是综合?
Synthesis is the construction of organic compounds. It is a specific branch of chemical synthesis which refers to the organic synthesis. Generally, organic compounds are complex than inorganic compounds. Therefore, the synthesis processes of these organic compounds are also complicated. A few different areas of organic synthesis include total synthesis, semisynthesis, methodology,立体选择性synthesis, etc.
The term total synthesis refers to the complete synthesis of organic compounds. Here, the starting materials are simple and natural precursors or petrochemical compounds. There are two approaches we can use to obtain a total synthesis: linear synthesis approach and convergent synthesis approach. In a linear synthesis approach, we can use a series of reaction steps, one after another, to synthesize the desired chemical compound. Convergent synthesis approach involves the individual production of separate pieces and combination at the end to obtain the desired product.
什么是反转合作?
Retrosynthesis is the technique of solving problems regarding organic synthesis. Therefore, this is an analysis. In this technique, we transform a target molecule into simple precursor molecules, without considering the reaction or thereagentsused during this transformation. Thereafter, we have to examine each precursor molecule using the same method. We have to do this until we reach a simpler, commercially available precursor molecule. Often, a synthesis process has more than one route for the production of the desired product. In that case, retrosynthesis is very useful in identifying these different routes and comparing them to determine the most suitable and effective route.
In this technique, there are different terms; we need to know the definitions. Retron refers to the simplest chemical compound that allows the transformation mentioned above. A retrosynthetic tree is a diagram showing all possible routes of synthesis. Synthon is a compound that can assist the transformation, while the target is the desired final product.
What is the Difference Between Synthesis and Retrosynthesis?
尽管术语的合成和逆合合成听起来相似,但它们是表达两种不同含义的两个不同术语。The key difference between synthesis and retrosynthesis is that the synthesis is the construction of organic compounds. But, retrosynthesis is the technique solving problems regarding organic synthesis. Therefore, the term synthesis refers to the production of the desired product, while the term retrosynthesis refers to the analyzing of the production process. There can be different possible routes for the production of the same compound. Here, we can use retrosynthesis for the determination of the most suitable and effective route.
Below infographic summarizes the difference between synthesis and retrosynthesis.
摘要 - 合成与回合合成
尽管术语的合成和逆合合成听起来相似,但它们是表达两种不同含义的两个不同术语。合成和逆合合成之间的关键区别在于合成是有机化合物的构建,而返回合成是解决有关有机合成问题的技术。在那里,合成是指生产过程,而返回合成是指生产过程的分析。这意味着;某个化合物的产生可能具有不同的合成途径,我们可以通过比较所有使用折叠合成的途径来确定合适的途径。
Reference:
1. “9.9 An Introduction to Organic Synthesis.” Chemistry LibreTexts, Libretexts, 5 June 2019,Available here.
2.“有机合成”。Wikipedia,Wikimedia基金会,2019年11月8日,Available here.
3. “Retrosynthetic Analysis.” Wikipedia, Wikimedia Foundation, 14 July 2019,Available here.
Image Courtesy:
1. “BHC synthesis of ibuprofen 2” By Me, I modified it – Wikimedia Commons: File:BHC synthesis of ibuprofen.png, (CC0) viaCommons Wikimedia
2.通过Commons Wikimedia
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