Difference Between Seminoma and Nonseminoma

Key Difference – Seminomavs Nonseminoma

Testicular肿瘤可以根据其特征形态特征将其分为不同的亚组。Seminomasand nonseminomas are arguably the two most frequently encountered varieties of neoplastic lesions in the malegonads。静态肿瘤是germ cell由类似于原始生殖细胞或早期肿瘤和非膜质肿瘤的细胞组成的肿瘤，含有未分化的embryonic stem cells可以区分不同的细胞系。因此，seminomas具有分化的细胞，与由未分化的细胞组成的非膜瘤不同，这些细胞有可能沿着任何细胞谱系分化。This can be considered as thekey differencebetween these tumors.

内容

1.Overview and Key Difference
2.什么是精子瘤
3.What is Nonseminoma
4.Similarities Between Seminoma and Nonseminoma
5.Side by Side Comparison – Seminoma vs Nonseminoma in Tabular Form
6。概括

什么是精子瘤?

静态肿瘤是germ cell tumors composed of cells that resemble primordial germ cells or early gonocytes. These are the commonest type of germ cell tumors with a peak incidence in the third decade of life.

这些肿瘤起源于前体病变，称为肿瘤内生殖细胞肿瘤（ITGCN）。青春期后，这种病变在子宫内发展并发展为肿瘤。ITGCN的显微镜检查显示，具有肿大的正常生殖细胞的大小是正常生殖细胞的两倍nucleusand a clear细胞质。

There are two main morphological varieties of seminomatous tumors as,

• Seminomas
• 精子细胞囊肿

Seminomas

These are the commonest type of germ cell tumors with a peak incidence in the third decade of life. A similar tumor called the dysgerminoma arises in the ovaries. Seminomas contain 12p isochromosome and express NANOG and OCT3/4. A fair majority of these tumors have KIT mutations also.

从形态上讲，经典的精液瘤是一种大肿瘤，形状是圆形的或多面体的。有一个发达的细胞膜，具有透明或水的细胞质。大多数细胞具有带有突出核的中央核的扩大。大约15％的精瘤含有合成型成素细胞，在这种情况下，血清HCG水平升高。

精子细胞瘤

符号肿瘤的这一子集主要影响65岁以上的老年男性。与经典的精瘤相反，精子细胞瘤是缓慢生长的肿瘤病变，发病率极低。由于这些肿瘤的生长速度缓慢，因此它们具有出色的prognosis。

精子细胞囊肿are composed of medium-sized cells with an eosinophilic cytoplasm.

What is Nonseminoma?

非肿瘤瘤tous tumors contain undifferentiated embryonic stem cells that can differentiate among different cell lines.

非膜质肿瘤的子类别是

• 胚胎癌
• Yolk sac tumor
• Choriocarcinoma

胚胎癌

这些肿瘤通常出现在20-30岁的年龄组中，比精液瘤更具侵略性。胚胎癌具有肾小管或肺泡类型的组织学排列。

Yolk Sac Tumors

这是3岁以下的婴儿和儿童中最常见的睾丸肿瘤。尽管上述年龄段的预后非常好，但成年人的蛋黄囊肿瘤可能会威胁生命。从组织学上讲，这些肿瘤是未包容的，外观粘稠。乳头状结构也很少在其中发现。

Choriocarcinoma

Choriocarcinomas are extremely rare but highly aggressive tumors accounting for less than 1% of the total testicular tumors. They do not give rise to an enlargement of the testicles and will be presented as a palpable nodule. There are two cell types in these tumors as syncytiotrophoblasts and cytotrophoblasts.

What is the Similarity Between Seminoma and Nonseminoma?

• Both are different varieties of testicular tumors.

What is the Difference Between Seminoma and Nonseminoma?

Seminoma vs Nonseminoma
静态肿瘤是germ cell tumors composed of cells that resemble primordial germ cells or early gonocytes.	非肿瘤瘤tous tumors contain undifferentiated embryonic stem cells that can differentiate among different cell lines.

摘要 - 精子瘤vs Nonseminoma

静态肿瘤是germ cell tumors composed of cells that resemble primordial germ cells or early gonocytes whereas nonseminomatous tumors are the masses that contain undifferentiated embryonic stem cells that can differentiate among different cell lines. Seminomas have differentiated cells, but nonseminomas have undifferentiated cells. This can be taken as the key difference between these tumors.

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Reference:

1.Kumar, Vinay, Stanley Leonard Robbins, Ramzi S. Cotran, Abul K. Abbas, and Nelson Fausto. Robbins and Cotran pathologic basis of disease. 9th ed. Philadelphia, Pa: Elsevier Saunders, 2010.

Image Courtesy:

1.非神经精液（2）淋巴结转移(CC BY-SA 3.0)viaCommons Wikimedia
2.’Testicle’ (Public Domain) viaCommons Wikimedia