Key Difference – Liposome vs胶束
两亲分子由hydrophilic头部和疏水性尾巴。因此,它们包含两者的部分特性polar and nonpolar. Depending on the type of charge they carry and other parameters, amphipathic molecules could be of various types. Liposome and micelle are amphipathic molecules.脂质体s are composed of a bilayer of amphipathic molecules where the two layers of molecules are arranged in two concentric circles. Micelles are closed脂质单层的地方脂肪酸are either present in the core or at the surface.This is thekey difference在脂质体和胶束之间。
内容
1.Overview and Key Difference
2.What is Liposome
3.什么是胶束
4.脂质体和胶束之间的相似性
5.Side by Side Comparison – Liposome vs Micelle in Tabular Form
6。概括
What is Liposome?
脂质体是由两倍分子的双层组成的结构,其中两个分子排列在两个同心圆中。在这种分子的排列中,外层亲水头被排列,它们向外指向外部环境。内部亲水性核由内层的亲水头形成。两层的疏水尾巴在两个同心环之间排列。
The formation of a liposome occurs by a process where the dry lipid molecules are hydrated through a nonpolar solvent that is followed an agitation process (mechanical induction). The major sources for liposome formation are phospholipid molecules along withcholesterol. The types of liposomes vary according to how they are formed. This criterion of liposome classification depends on the extent of mechanical agitation and the use of a polar solvent in some instances. These types of liposomes include Small Unilamellar Vesicles (SUV), Large Unilamellar Vesicles (LUV), Large Multilamellar Vesicles (MLV) and Multivesicular Vesicles (MVV).
在人体中,脂质体被富含网状内皮系统的器官吸收。因此,脂质体的主要目标是药物递送,它针对这些器官。为了靶向特定的肿瘤细胞,将脂质体涂有特殊聚合物。相对脂质体的生产过程成本高昂。因此,这些脂质体仅在viral infectiontreatment and tumor cell killing. Drug administration is achieved via the parenteral route.
什么是胶束?
胶束is defined as a lipid molecule that is arranged in a spherical form in aqueous solution. Micelles are formed in response to the amphipathic nature of fatty acids. Micelles are composed of both hydrophilic regions and hydrophobic regions. The hydrophilic regions are polar head groups whilst the hydrophobic regions are the long hydrophobic chains (tails). The polar head groups usually involve in the formation of the outside layer of the micelles since they have the ability to interact with water due to their polar nature. The hydrophobic tails are present inside of the structure to prevent the interaction with water due to their nonpolar nature.
由胶束产生的脂肪酸包含一个与两个烃链相反的烃链。该结构使脂肪酸能够发展出球形形状,从而减少了脂肪酸分子本身内发生的空间障碍。胶束的尺寸从02 nm到20 nm不等。大小在很大程度上取决于胶束的组成和浓度。由于分子的两亲性,胶束也自发地形成水。
In the context of the human body, micelles help in absorption of lipid and fat-soluble vitamins such asvitamin A,D, E andK. They also help thesmall intestine在吸收肝脏的必需脂质和维生素中gallbladder.
脂质体和胶束之间有什么相似之处?
- 脂质体和胶束均由两亲分子组成。
- 脂质体和胶束都是囊泡结构。
- 脂质体和胶束都有重要的药物应用。
- 脂质体和胶束在靶向药物输送中都起着重要作用。
- 脂质体和胶束的形成大大增加了特定温度。
What is the Difference Between Liposome and Micelle?
脂质体vs Micelle |
|
脂质体is a structure that consists of a bilayer of amphipathic molecules where the two layers of molecules are arranged in two concentric circles. | 胶束是在水溶液中以球形形式排列的脂质分子的结构。 |
Constituents | |
脂质体s are formed mainly by phospholipid molecules such as cholesterol etc. | 胶束s are formed by surfactant molecules such as detergents, emulsifiers etc. |
地层温度 | |
脂质体formation occurs at the transition temperature. | Kraft temperature is the minimum temperature value of micelle formation. |
概括–脂质体vs胶束
Amphipathic molecules contain partial polar and partial nonpolar properties. Liposomes and micelles fall under the category of amphipathic molecules. The liposomes are composed of a bilayer of amphipathic molecules where the two layers of molecules are arranged in two concentric circles. The formation of a liposome occurs by a process where the dry lipid molecules are hydrated through a nonpolar solvent. It is completed with physical agitation. Liposomes are used only during viral infection treatment and tumor cell killing since the production process is costly. Micelles are closed lipid monolayers where the fatty acids are either present in the core or at the surface. Micelles help in absorption of lipid and fat-soluble vitamins; vitamin A, D, E and K. This is the difference between liposome and micelle.
Reference:
1.“结构生物化学/脂质/胶束。”结构生物化学/脂质/胶束 - Wikibooks,开放世界的开放书籍。Available here
2.“胶束和脂质体之间的显着差异。”生物学方向。Available here
3.Akbarzadeh,Abolfazl等。“脂质体:分类,准备和应用。”纳米级研究信,第1卷。8,不。1,2013,p。102.,doi:10.1186/1556-276x-8-102
Image Courtesy:
1.’liposome necon-en’by supermanu - 自己的工作,(CC BY-SA 3.0)通过Commons Wikimedia
2.’Phospholipids aqueous solution structures’By Mariana Ruiz Villarreal ,LadyofHats – Own work, (Public Domain) viaCommons Wikimedia
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