Thekey difference在L和S冠状病毒之间L冠状病毒表现出“ CT”单倍型having the codon of Leucine at T28,144 while S coronavirus exhibits a ‘TC’ haplotype having the codon of Serine at C28,144.
严重的急性呼吸综合征冠状病毒2或SARS-COV-2是冠状病毒疾病 - 共同19. The virus was previously known as 2019 novel coronavirus. This virus is genetically closely related to the coronavirus responsible for theSARSoutbreak of 2003. Hence, the novel coronavirus is named based on the relationship with SARS-CoV-1. COVID 19 is a respiratory disease which transmits via droplets and physical contact. The most common symptoms of COVID 19 are fever, dry cough, tiredness and shortness of breath.
Researchers in China have found out two strains of SARS-CoV-2 that are circulating among the human population. They are “L” and “S” types. These two strains are very similar to each other. L lineage is the major (approximately 70%) while S is the minor (approximately 30%). Both L and S lineages exhibit complete linkage between the two SNPs located at location 8,782 and 28,144.
内容
1.Overview and Key Difference
2.What is L Coronavirus
3.What is S Coronavirus
4.L和S冠状病毒之间的相似之处
5。并排比较Ta - L和S冠状病毒bular Form
6。概括
What is L Coronavirus?
L coronavirus is one of the two strains of SARS-CoV-2. It is found to be prevalent in the early stages of COVID 19 outbreak in Wuhan. L coronavirus originated from the older S coronavirus. This strain is more aggressive and is responsible for 70% of COVID 19 cases around the world.
L lineage exhibits a complete linkage between the two SNPs at location 8,782 (ORF1AB:T8517C,同义词)和28,144(ORF8: C251T, S84L). It exhibits a ‘CT’ haplotype since T28,144 is in the codon of Leucine. Furthermore, L lineage had accumulated a significantly higher number of derived mutations than S lineage.
什么是冠状病毒?
S coronavirus is the second lineage of SARS-CoV-2. It is the older version. It is believed that L type is derived from S type. S coronavirus accounts for approximately 30% COVID cases. S type strains continuously infect new patients because it is less severe, and people carry it for a longer time before taking medicines. Therefore, it increases the risk of transmission. Similar to L lineage, S lineage shows complete linkage in two SNPs. Moreover, it exhibits “TC” haplotype having codon of Serine in the C28,144.
L和S冠状病毒之间有什么相似之处?
- SARS-COV-2已演变为两个称为“ L”和“ S”类型的主要谱系。
- Whole-genome comparisons further confirm the separation of the L and S lineages
- These strains indicate that the virus is mutating.
- L和S冠状病毒在位置8,782(ORF1AB:T8517C,同义词)和28,144(ORF8:C251T,S84L)中均显示了SNP的完整联系。
- 两个谱系的传输或复制率可能不同。
What is the Difference Between L and S Coronavirus?
L and S coronaviruses are two strains of SARS-CoV-2. L coronavirus is the more prevalent strain, which is one of the two strains of SARS-CoV-2. S coronavirus is a less severe strain of SARS-CoV-2. So, this is the key difference between L and S coronavirus. L coronavirus is responsible for about 70% cases while S coronavirus is responsible for about 30% cases.
Moreover, another difference between L and S coronavirus is that the L lineage exhibits a ‘CT’ haplotype while the S lineage exhibits a ‘TC’ haplotype.
The below infographic tabulates more differences between L and S coronavirus.
概括– L vs S Coronavirus
L and S are two strains of SARS-CoV-2. They are more similar to each other. But, “L” coronavirus is more prevalent and is responsible for more than 70% of cases while “S” coronavirus is responsible for about 30% of the cases. Moreover, L lineage exhibits ‘CT” haplotype while S lineage exhibits a ‘TC’ haplotype. S lineage is evolutionary more related to animal coronaviruses. L lineage, on the other hand, had accumulated a significantly higher number of derived mutations than S lineage. Thus, this summarizes the difference between L and S coronavirus.
Reference:
1.麦克纳马拉,亚历山大。“冠状病毒:侵略性'L型'菌株影响70%的病例。”英国广播公司科学焦点杂志,2020年4月7日,Available here.
2. Tang, Xiaolu, et al. “On the Origin and Continuing Evolution of SARS-CoV-2.” OUP Academic, Oxford University Press, 3 Mar. 2020,Available here.
Image Courtesy:
1. “SARS-CoV-2 without background” ByCDC/ Alissa Eckert, MS; Dan Higgins, MAM – This media comes from the Centers for Disease Control and Prevention's Public Health Image Library (PHIL) (Public Domain) viaCommons Wikimedia
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