Thekey difference在氟康唑和伊曲康唑之间，尽管两者都是抗真菌药物，但fluconazole is not active againstAspergilluswhereas Itraconazole is active againstAspergillus. Therefore, itraconazole has a broad range of activity than fluconazole.
The trade name of fluconazole isDiflucan, and the trade name of itraconazole isSporanox.
内容
1.Overview and Key Difference
2.What is Fluconazole
3.What is Itraconazole
4.Side by Side Comparison – Fluconazole vs Itraconazole in Tabular Form
5.概括
What is Fluconazole?
Fluconazole is an antifungal medication for treating fungal infections including candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and pityriasis versicolor. The chemical formula of fluconazole is C13H12F2N6O, and the molar mass is 306.27 g/mol. The melting point is around 138-140°C.
Figure 01: The Skeletal Structure of Fluconazole
Fluconazole falls into the class of azoles, which are antifungals. However, it is different from other azole antifungals by the presence of a triazole ring instead of an imidazole ring (as in other azoles). In addition, fluconazole is for the oral use (unlike imidazole antifungals). Fluconazole works best againstCandidaspecies, some dimorphic fungi, and dermatophytes.
Side Effects:
Common side effects of fluconazole include rashes, headache, dizziness, nausea, diarrhoea, etc. Some rare side effects include oliguria, seizures, alopecia, liver failure, etc. There are very rare adverse effects as well. Ex: prolonged QT interval.
What is Itraconazole?
Itraconazole is an antifungal medication to treat fungal infections such as aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. The routes of administration are oral or IV (intravenously). Specifically, this medication is useful in treatingAspergillusinfections. Moreover, recent studies have shown that this medicine has anticancer properties as well.
Itraconazole的化学公式是C35H38Cl2N8O4，摩尔质量为705.24 g/mol。它具有非常复杂的化学结构。这种化合物表现出手性。因此是一种外星人混合物。Itraconazole的熔点为170°C。
Figure 02: The Chemical Structure of Itraconazole
Side Effects:
The common side effects of Itraconazole include nausea, vomiting, diarrhoea, rash, and headache. There are some rare side effects as well; such side effects include elevated alanine aminotransferase levels, congestive heart failure, liver failure, etc.
What is the Difference Between Fluconazole and Itraconazole?
氟康唑与Itraconazole |
|
| Fluconazole is an antifungal medication mainly used to treat infections caused byCandidaspecies, some dimorphic fungi, and dermatophytes. | Itraconazole is an antifungal medication mainly used to treat aspergillosis and blastomycosis. |
| Chemical Formula | |
| C13H12F2N6O. | C35H38Cl2N8O4 |
| Molar Mass | |
| 306.27 g/mol。 | 705.24 g/mol。 |
| Melting Point | |
| Around 138-140°C. | 170°C. |
| Treatment AgainstAspergillusInfection | |
| Not active againstAspergillus. | Active againstAspergillus. |
| Side Effects | |
| Rashes, headache, dizziness, nausea, diarrhoea, etc. | Nausea, vomiting, diarrhoea, rash, and headache. |
摘要 - 氟康唑与Itraconazole
Fluconazole and Itraconazole are two important antifungal medications. The key difference between fluconazole and Itraconazole is that the fluconazole is not active againstAspergilluswhereas itraconazole is active againstAspergillus.
Reference:
1. “Itraconazole-A Very Low Bioavailability BCS Class II Drug Case Study.” DisperSol Technologies.Available here
2.“氟康唑。”氟康唑|C13H12F2N6O |Chemspider。Available here
3. “Fluconazole.” Wikipedia, Wikimedia Foundation, 30 Apr. 2018.Available here
Image Courtesy:
1.’Fluconazole skeletal formula’By Vaccinationist – PubChem, (Public Domain) viaCommons Wikimedia
2.’Itraconazole’By Shaddack – Own work using: ChemWindow, (Public Domain) viaCommons Wikimedia
发表评论