The key difference between Creatinine Clearance and GFR relies on the type of test that helps analyze each measurement.Creatinine clearance analysis takes place via urine test whereas GFR analysis takes place via a blood test.
肾的健康取决于efficiency and accuracy of kidney functioning. Therefore, the three main steps of urine formation are vital for renal health. The three main steps areultrafiltration, selective再吸收, and tubular secretion. Ultrafiltration takes place in theglomerulus,并且肌酐清除率和GFR都与超滤过程的效率有关。
内容
1.Overview and Key Difference
2.What is Creatinine Clearance
3.什么是GFR
4.肌酐清除与GFR之间的相似之处
5.Side by Side Comparison – Creatinine Clearance vs GFR in Tabular Form
6。概括
什么是肌酐清除?
Creatinine is a waste product that results from the normal breakdown process of muscle tissue. Ultrafiltration filters creatinine into the urine during urine production in kidneys and there is no reabsorption of creatinine into the bloodstream. Creatinine clearance is the amount of blood filtered by kidneys in each minute in order to make blood free of creatinine. In a healthy woman, the creatinine clearance is about 95 mL per minute. In a healthy man, the creatinine clearance is 120 mL per minute. Therefore, our kidneys make 95-120 ml of blood free from creatinine per minute.
肌酐清除测试的主要功能是预测肾功能。因此,肌酐清除率水平显示了肾脏过滤血液的能力以及超滤过程在尿液形成中的效率。一个简单的尿液测试揭示了肌酐的间隙。为了进行此测试,应在过去24小时内收集一个人的尿液。然后,可以估计尿液样品中存在的肌酐水平。由于有必要收集尿液24小时,因此测试可能有些不便。但是,诊断某些肾脏状况是一个重要的测试。
什么是GFR?
Glomerular Filtration Rate (GFR) is the rate at which blood passes through the glomerulus during ultrafiltration. During glomerular filtration, all blood constituents except blood cells are filtered into the tubular network of thenephron通过Bowman’s capsule. The filtration takes place according to a pressure gradient. The glomerular filtration takes place in nephron during urine formation. Thus, the glomerular filtration test determines the functionality of the kidney.
GFR test is done via blood sample analysis. The blood creatinine levels determine the glomerular filtration rate. In addition to blood creatinine levels, parameters such as age, ethnicity, gender, height and weight affect the glomerular filtration rate.
肌酐清除和GFR之间有什么相似之处?
- 肌酐清除率和GFR都可以预测超滤过程的效率。
- They measure the creatinine levels; however, the source differs.
- Both predict the renal health of an individual.
- Moreover, they depend on factors such as age, gender, weight, etc.
What is the Difference Between Creatinine Clearance and GFR?
Creatinine clearance test and GFR test are two tests to measure the efficiency of the kidneys during its filtration step. However, the sources of the two tests are different; the source of creatinine clearance is a urine sample while the source of GFR is the blood. So, this is the key difference between creatinine clearance and GFR.
The below infographic summarizes the difference between Creatinine Clearance and GFR.
概括– Creatinine Clearance vs GFR
Creatinine clearance and GFR measure the efficiency of kidneys during ultrafiltration. Creatinine is the marker to measure the efficiency of the kidneys. In this context, creatinine clearance is the amount of blood filtered by kidneys in each minute in order to make blood free of creatinine. In contrast, GFR measures the blood creatinine levels to analyze the glomerular filtration rate. Age and gender play a major role in determining both the measurements. So, this summarizes the difference between creatinine clearance and GFR.
Reference:
1.Simetić,Lucija等。“肌酐清除率和估计的肾小球滤过率 - 当它们可互换时。”美国国家医学图书馆,2015年9月,美国国家医学图书馆,Available here.
Image Courtesy:
1. “Creatinine” By Jesse – Own work(CC BY-SA 3.0)viaCommons Wikimedia
2. “Anatomy and physiology of animals Filtration in the glomerulus capsule” By The original uploader was Sunshineconnelly at English Wikibooks. – Transferred from en.wikibooks to Commons by Adrignola using CommonsHelper(CC BY 3.0)viaCommons Wikimedia
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