本构和调节的胞吐作用之间的差异|比较类似术语之间的差异

Thekey differencebetween constitutive and regulated exocytosis is thatin constitutive exocytosis, secretory materials are continuously released, while in regulated exocytosis, secretory materials are stably accumulated in secretory vesicles as storage sites.

Exocytosis is the process by which cells release molecules to the outside of the cell. By exocytosis, cells transport molecules to the质膜许多细胞也将蛋白质释放到细胞外液. In addition, cells communicate with each other via a variety of signalling molecules. Intracellular signalling molecules are released by secretory vesicles. There are two types of exocytosis as constitutive exocytosis and regulated exocytosis. Cells carry out constitutive exocytosis to transfer molecules from the Golgi network to the outer surface of the cell. In constitutive exocytosis, secretory materials are continuously released. On the other hand, cells carry out regulated exocytosis in response to specific conditions, signals or biochemical triggers. In regulated exocytosis, secretory materials are released in a highly regulated manner into secretoryvesicles.

内容

1.Overview and Key Difference
2.什么是构型胞吐作用
3.What is Regulated Exocytosis
4.Similarities Between Constitutive and Regulated Exocytosis
5.Side by Side Comparison – Constitutive vs Regulated Exocytosis in Tabular Form
6。概括

什么是组成型胞吐作用？

组成型胞吐作用是两种类型的胞吐作用之一。细胞进行构成胞吐作用，以将分子从高尔基网络转移到细胞的外部环境。它是胞吐作用的默认途径，对于运输诸如在质膜中起作用的受体之类的蛋白质很重要。

Difference Between Constitutive and Regulated Exocytosis

Figure 01: Constitutive vs Regulated Exocytosis

Moreover, in constitutive exocytosis, secretory materials are released continuously. The rate of constitutive exocytosis is well controlled. This rate depends on their rate of production, which is regulated by transcription and translation. But unlike regulated exocytosis, secretory materials are not released in a regulated manner.

What is Regulated Exocytosis?

Regulated exocytosis is a more specialized form of exocytosis that is triggered when a cell receives a signal from the outside. Cells carry out regulated exocytosis in response to specific conditions, signals or biochemical triggers. Cells release materials in a highly regulated manner. Secretory materials are first accumulated in secretory vesicles in regulated exocytosis. In this way, cells release cytokines, hormones, neurotransmitters, neuropeptides and other small signalling molecules.

图02：受调节的胞吐作用

Regulated exocytosis forms the basis for many intercellular signalling processes. There are two pathways of regulated exocytosis. The first pathway primarily secretes polypeptides while the second pathway primarily secretes low-molecular-weight substances.

What are the Similarities Between Constitutive and Regulated Exocytosis?

组成型和调节的胞吐作用是两种类型的胞吐作用。
The fundamental pathway and the basic mechanism for regulated and constitutive exocytosis are similar.

What is the Difference Between Constitutive and Regulated Exocytosis?

Exocytosis can be constitutive or regulated. In constitutive exocytosis, secretory materials are released continuously. But, in regulated exocytosis, secretory materials are released into secretory vesicles on-demand via secretagogues and signal transduction. So, this is the key difference between constitutive and regulated exocytosis.

More differences between constitutive and regulated exocytosis are shown in tabular form in the below infographic.

概括– Constitutive vs Regulated Exocytosis

组成型和调节的胞吐作用是两种类型的胞吐作用。在构型胞吐作用中，分泌材料连续释放。不涉及秘密的囊泡或储存囊泡。这对于运输诸如在质膜中起作用的受体之类的蛋白质很重要。另一方面，受调节的胞吐作用以调节方式发生。分泌材料通过分泌囊泡释放。当单元从外部接收信号时，它会触发。细胞因子，激素，神经递质和其他小信号分子的释放是通过调节的胞吐作用发生的。因此，这是组成型和调节胞吐作用之间差异的摘要。

Reference:

1. Gerber, Stefan H., and Thomas C. Südhof. “Molecular Determinants of Regulated Exocytosis.” Diabetes, American Diabetes Association, 1 Feb. 2002,Available here.
2.阿尔伯茨，布鲁斯。“从反式高尔基网络到细胞外部的运输：胞吞作用。”细胞的分子生物学。第四版，美国国家医学图书馆，1970年1月1日，Available here.