Thekey difference在钙调蛋白和肌钙蛋白C之间钙调蛋白只能与钙ions whereas troponin C is able to bind with both calcium andmagnesium离子。
Calmodulin and troponin C are proteins ineukaryotes。Both act as calcium-binding messenger proteins. More importantly, calmodulin can bind with only calcium while troponin C can bind with both calcium and magnesium.
内容
1.Overview and Key Difference
2.What is Calmodulin
3.What is Troponin C
4.Side by Side Comparison – Calmodulin vs Troponin C in Tabular Form
5.概括
什么是钙调蛋白?
Calmodulin refers to the calcium modulated protein. It can be found in all eukaryotic cells. It can also act as a multifunctional intermediate calcium-binding protein. This protein acts as an intercellular target for secondary messenger calcium ions. Moreover, for the activation of the calmodulin protein, the binding of the secondary messenger calcium ions is neccessary. Once it is activated, it can act as a part of the calcium signal transduction pathway.
When considering the structure of this protein, it is a small protein having about 148amino acids。它大约有两个球状区域。这些区域中的每一个都包含两个可以与钙离子结合的EF手基序。这些球状区域之间有一个灵活的接头区域。因此,钙调蛋白分子具有四个用于钙离子结合的位点。
Moreover, the calmodulin protein can bind with a variety of target molecules. Therefore, it is very important to have flexibility in this protein. The generic shape of the non-polar grooves in the binding sites allows it to bind with a variety of targets.
What is Troponin C?
Troponin C is a protein that exists as a part of the troponin complex. There are four EF motifs in the troponin C molecule for the bonding of calcium ions. Moreover, this protein exists as a component in thin filaments in combination with actin and tropomyosin.
肌钙蛋白C分子包含两个裂片:N叶和C叶。C叶作为结构成分很重要,有助于与肌钙蛋白I的N结构域结合。此外,C叶也能够与钙离子或镁离子结合。但是,N叶仅与钙离子结合。它是该蛋白质的调节叶,并在与钙离子进行竞标后,它可以与肌钙蛋白I的C结构域结合。
There are two subtypes of troponin C as slow troponin and fast troponin. Moreover, there are a number of mutations for this protein as well. These mutations can cause structural alterations of troponin C and in the binding of calcium and magnesium ions as well. These mutations can cause abnormalities in muscle contractions.
What is the Difference Between Calmodulin and Troponin C?
Calmodulin and troponin C are proteins in eukaryotes. Both these proteins have four EF-hand motifs that can bind with calcium (and/or magnesium) ions. However, the key difference between calmodulin and troponin C is that calmodulin can bind with only calcium ions whereas troponin C is able to bind with both calcium and magnesium ions.
Below infographic summarizes the difference between calmodulin and troponin C .
概括– Calmodulin vs Troponin C
Calmodulin and troponin C are proteins in eukaryotes. The key difference between calmodulin and troponin C is that calmodulin can bind with only calcium ions whereas troponin C is able to bind with both calcium and magnesium ions.
Reference:
1.Issa, Ziad F., et al. “Ventricular Arrhythmias in Inherited Channelopathies.”Clinical Arrhythmology and Electrophysiology: A Companion to Braunwalds Heart Disease, 2012, pp. 645–684., doi:10.1016/b978-1-4557-1274-8.00031-2.
Image Courtesy:
1.“钙调蛋白”用户Magnus Manske en.wikipedia – Originally from en.wikipedia: 13:27, 22 June 2004 Magnus Manske 564×519 (34,897 bytes) ({{PD}}) (Public Domain) viaCommons Wikimedia
2. Arcadian的“ Troponino” - Troponino.jpg通过Commons Wikimedia
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