Key Difference – BCellReceptorvs T Cell Receptor
The defense system of the body is mainly developed with the presence of白细胞反对入侵的行为病原体如virusesandbacteria。不同ent types of leukocytes with different functions are present in the human body.B cells and T cells是涉及启动特定的主要白细胞immune responses。B细胞在特定的生产中起作用antibodies参与humoral adaptive immunity。T细胞参与细胞介导的适应性反应。两个细胞都启动了不同的反应。在B细胞和T细胞中发现的受体分别称为B细胞受体和T细胞受体。抗原的检测过程根据白细胞的类型为B细胞或T细胞。B细胞受体与可溶性抗原结合,该抗原自由存在,而T细胞受体仅在主要组织相容性复合物(MHC)上显示抗原才能识别抗原。这是关键区别在B细胞受体和T细胞受体之间。
CONTENTS
1。概述和关键差异
2。What is B Cell Receptor
3。What is T Cell Receptor
4。B细胞受体和T细胞受体之间的相似性
5.Side by Side Comparison – B Cell Receptor vs T Cell Receptor in Tabular Form
6.Summary
What is B Cell Receptor?
B细胞受体(BCR)是位于B细胞外表面上的跨膜受体蛋白。在骨髓中产生B细胞以及成熟。B细胞发育是由功能性B细胞受体的产生引发的(pre-BCR)。前BCR由两个组成immunoglobulinheavy chains and two surrogate light chains. These chains cooperate with IgA and IgB which are signaling molecules. The BCRs which is also known as integral membrane proteins reside in many identical copies at the surface of the B cells.
B细胞受体复合物是由一个反gen binding subunit (MIg) which is made of two immunoglobulin heavy chains and two immunoglobulin light chains and a disulphide- linked heterodimer of Ig-alpha and Ig–beta proteins together, that make up a signaling subunit. The heavy chains of BCRs consist of gene segments like 51 VH, 25 DH, 6 JH and 9 CH. 51 VH segments that encode the N terminal of the antibody. This N terminal of the antibody includes the first two hyper-variable regions. 25 DH segment is a diversity gene segment which encodes the third part of the hyper-variable region. 6 JH is the joining gene segment which encodes the V region, and the 9 CH segment encodes the C region of the BCR.
BCR具有特定的结合位点,该位点与称为抗原决定因素的抗原区域结合。结合由非共价力,受体表面的互补性和抗原决定剂的表面辅助。如果BCR存在于B淋巴细胞,,,,it transmits intracellular signals which help in the regulation of cell growth and differentiation while also binding to specific antigens to generate an immune response. Memory cells that move through the circulation to produce immune responses are also produced by the activation of BCRs. The antigens which are bound to this, occur with the engulfment by the B cells due to receptor-mediated内吞作用。然后将抗原消化成小片段,后来显示在II类组织相容性分子内部的细胞表面。
什么是T细胞受体?
T细胞受体(TCR) is found on the surface of T lymphocytes. TCRs function is to recognize foreign particles known as antigens to initiate an immunological response. During normal conditions, the body develops and produces many T cells, and each of the cells possesses a unique TCR on its surface. The development of TCR occurs due to the recombination of genes which encode TCRs prior to the encounter of antigens. In the surface of a T cell, identical TCRs occur in larger quantities. The antigens which bind with the TCRs are small peptide particles which are epitopes that occur through the phagocytosis of the foreign pathogen. These表位由主要的组织相容性复合物(MHC)分子显示。
T cells are of two types.Cytotoxic T cells(Tc) and助手T细胞(Th). The TCRs present on Tc cells recognize foreign epitopes which are presented by MHC Class I molecules. They possess the ability to differentiate nonself (foreign) antigens from self-antigens. Therefore, it prevents the occurrence of immune responses against the body’s own cells. Th cells recognize antigens displayed on MHC Class II molecules. A surfaceglycoproteinCD8in Tc cells andCD4在外国表位与两种类型T细胞的结合过程中涉及到。CD4和CD8共受体分别识别在MHC II类和MHC I类分子上介绍的抗原。
TCR是由两个链组成的跨膜异二聚体。TCR的典型结构在传输信号方面不足。这是由于它们拥有的短细胞质链。为了克服这些情况,TCR会关联CD3跨膜蛋白。CDS复合物由不同的亚基组成,包括CDE,CDG,CDD和Z(CDZ)。这会开发能够传递信号的TCR复合物。
由于有可能通过TCR结合自我抗原,一旦抗原与TCR绑定,它不会立即引发免疫反应。这称为T细胞耐受性。为了引发免疫反应,T细胞(TCR)需要以源自抗原呈现细胞的共刺激分子形式的第二个信号。
What are the Similarities Between B Cell Receptor and T Cell Receptor?
- Both receptors are integral membrane proteins.
- 作为许多相同的副本,在细胞表面上存在。
- Both types possess unique binding sites.
- Both types of receptors are encoded by genes that are assembled through recombination of segments of DNA.
- Both receptors bind to the antigenic determinant portion of the antigen, and the binding occurs through noncovalent forces.
B细胞受体和T细胞受体有什么区别?
B细胞受体与T细胞受体 |
|
B细胞受体是位于B细胞外表面上的跨膜受体蛋白。 |
T细胞受体is an antigen recognizing molecule present on the surface of T lymphocytes. |
Recognition of Epitope-antigens | |
B细胞受体识别可溶性抗原。 | T细胞受体识别MHC I类和MHC II类分子上显示的抗原。 |
摘要 - bCellReceptorvs T Cell Receptor
B cells and T cells are important components of the immunity system. Both cells possess cell surface receptors known as BCR and TCR respectively. Both receptors are integral membrane proteins and present on the cell surface as many identical copies. Both BCR and TCR possess unique binding sites. They differ in the process of the recognition of antigens. The BCRs detect and bind to soluble antigens that are present freely whilst TCR only recognize antigens when displayed on Major Histocompatibility Complex (MHC). This is the difference between B cell receptor and T cell receptor.
Download the PDF Version of B Cell Receptor vs T Cell Receptor
您可以下载本文的PDF版本,并根据引文注释将其用于离线目的。请在此处下载PDF版本之间的区别B cell Receptor and T cell Receptor
参考:
1。“B-Cell Receptor Complex.” Thermo Fisher Scientific.在这里可用
2.“家。”T细胞受体(TCR)概述|Thermo Fisher科学。在这里可用
3. libretexts。“ 18.4:B淋巴细胞和抗体。”生物学库,库,2017年1月2日。在这里可用
图片提供:
1. Minimuns的CD22和B细胞受体信号传导过程的'shemsatic表示 - 使用PowerPoint绘制(CC BY-SA 3.0)通过下议院维基梅迪亚
2。’TCRComplex’(CC BY-SA 3.0)通过下议院维基梅迪亚
Leave a Reply