What is the Difference Between T2 and T4 Bacteriophage

Thekey differencebetween T2 and T4 bacteriophageis that in T2 bacteriophage, enzyme DNA Topo II is coded by the two genes 39 and 60m, while in T4 bacteriophage, this enzyme is coded by the three genes 39, 60, and 52.

噬菌体是一种感染细菌的病毒。Bacteriophages are bacteria eaters since they destroy host cells once infected. There are many types of bacteriophages with reference to morphology and nucleic acid. T2 bacteriophage and T4 bacteriophage are two such types. Both types infect and killEscherichia coli。

内容

1.Overview and Key Difference
2.What is T2 Bacteriophage
3.What is T4 Bacteriophage
4.Similarities – T2 and T4 Bacteriophage
5.T2 vs T4噬菌体以表格形式
6.摘要 - T2 VST4噬菌体

什么是T2噬菌体？

T2噬菌体是一种感染和杀死的病毒E. coli。It is known as enterobacteria-phage T2. Bacteriophage T2 belongs to the phylum Uroviricota, family Myoviridae, genus Tequatrovirus and speciesEscherichia病毒T4。T2噬菌体的基因组由线性双链DNA组成。DNA链的末端由重复组成。T2噬菌体具有由两个基因39和60编码的噬菌体酶。39蛋白具有ATPase活性，并且60具有复杂的形成功能。

T2 bacteriophage attaches to the surface of the bacterium by proteins or tail fibers and injects its genetic material (either DNA or RNA) into the host cell. The injected genetic material interferes with the bacterium cell structure and machinery. It uses the bacteriumribosomesto replicate and synthesize viral cellular components such as viral proteins. Therefore, new T2 bacteriophages originate from the infected bacterial cell and become responsible for the lysis of bacterial cells when releasing new viral progeny. New T2 macrophages continue the infection of new bacterial cells.

What is a T4 Bacteriophage?

T4 bacteriophage is a virus that infectsE.coliand eventually kills the bacterium. It is known asEscherichia virus T4。T4噬菌体是一种双链DNA病毒。它属于Myoviridae家族和tevenviridae的亚家族。T4噬菌体通过lytic cyclebut not thelysogenic cycle。The double-stranded DNA of the T4 bacteriophage is about 169 kbp long. It encodes 289 proteins. The genome of T4 is terminally redundant and consists of eukaryotic similar intron sequences.

Compared to other types of bacteriophages, T4 bacteriophage is a relatively large virus with dimensions of 90 nm width and 200 nm length. The tail portion of the T4 bacteriophage is hollow and passes the nucleic acid to the infecting bacteria upon attachment. The tail is a complex structure in T4 bacteriophages with a high number of proteins for attachment and function. T4 bacteriophage consists of 3 genes to encode viral proteins. They are gene 39, 60, and 52.

What are the Similarities Between T2 and T4 Bacteriophage?

• Both are viruses that infect大肠杆菌。
• They have double-stranded DNA.
• T2和T4噬菌体都经历了裂解周期，导致细菌死亡。
• They hijack the bacterial cell mechanism to produce viral proteins.

What is the Difference Between T2 and T4 Bacteriophage?

T2 bacteriophage has two genes 39 and 60, to code DNA Topo II enzyme, while T4 bacteriophage has three genes 39,60, and 52 to code DNA Topo II enzyme. Thus, this is the key difference between T2 and T4 bacteriophage. Moreover, the tail portion of the T2 bacteriophage is not complex when compared to the tail of the T4 bacteriophage.

The below infographic presents the differences between T2 and T4 bacteriophage in tabular form for side by side comparison。

Summary – T2 vs T4 Bacteriophage

噬菌体是一种感染细菌的病毒。在感染过程中，噬菌体附着在易感细菌上，释放遗传物质并感染宿主细胞。T2噬菌体和T4噬菌体是两种类型的类型。两种类型感染并杀死Escherichia coli.T2噬菌体由由两个基因39和60编码的噬菌酶组成。T4噬菌体由3个基因组成，用于编码病毒蛋白。它们是基因39、60和52。与T4噬菌体的尾巴相比，T2噬菌体的尾部不复杂。T2和T4噬菌体都经历了裂解周期，从而导致细菌细胞死亡。因此，这是T2和T4噬菌体之间差异的摘要。

Reference:

1.“”Bacteriophage。” Encyclopædia Britannica, Encyclopædia Britannica, Inc.
2. G;, Gary TP; Colowick NE; Mosig. “A Species Barrier between Bacteriophages T2 and T4: Exclusion, Join-Copy and Join-Cut-Copy Recombination and Mutagenesis in the Dctpase Genes。” Genetics, U.S. National Library of Medicine.

Image Courtesy:

1.“”Structure of a Myoviridae bacteriophage 2”切尔西·邦纳（Chelsea Bonnain），迈亚·布雷特巴特（Mya Breitbart）和克里斯汀·N·巴克（Kristen N.(CC BY-SA 4.0)via Commons Wikimedia
2. “T4likevirus virion“ 经过ViralZone，Sib Swiss生物信息学研究所：Tevenvirinae -(CC BY 4.0)via Commons Wikimedia