Thekey differencebetween CD55 and CD59is that CD55 is a protein that regulates the complement system by inhibiting aggregation of C3 convertases of the classical and alternative pathways and forming complement membrane attack complexes, while CD59 is a protein that regulates the complement system by preventing C9 from polymerizing and forming complement membrane attack complexes.
补体膜攻击复合物是由于宿主的补体系统的作用而在病原体细胞膜表面形成的蛋白质复合物。补体膜攻击复合物的形成触发病原体细胞裂解。有不同的分子可以调节补体系统和补体膜攻击复合物的形成。因此,CD55和CD59是两种通过抑制补体膜攻击复合物的形成来调节补体系统的蛋白质。
内容
1.Overview and Key Difference
2.What is CD55
3.What is CD59
4.Similarities – CD55 and CD59
5.CD55vs CD59 in Tabular Form
6。摘要 - CD55 vs CD59
What is CD55?
CD55, also known ascomplement decay-accelerating factor或者DAF, is a protein that regulates the complement system by inhibiting aggregation of C3 convertases of the classical and alternative pathways and forming complement membrane attack complex. CD55 regulates the complement system on the cell surface. It usually recognizes C4b and C3b fragments formed during the activation of C4 (classical and alternative pathway) and C3 (alternative pathway). Interaction of CD55 with C4b of classical and lectin pathways interferes with the conversion of C2 to C2b, thereby preventing the formation of C4b2a (C3 convertase in classical and lectin pathway). On the other hand, when CD55 interacts with C3b of the alternative pathway, it interferes with the conversion of factor B to Bb by factor D. Thus, this prevents the formation of C3bBb (C3 convertase in the alternate pathway). Therefore, CD55 basically inactivates C3 convertases, which indirectly prevents the formation of the membrane attack complex.
此外,该糖蛋白是由CD55人类的基因。CD55is also broadly distributed among造血和非脊髓细胞。另外,它也是Cromer血型系统的决定因素。
CD59是什么?
CD59is a protein that regulates the complement system by preventing C9 from polymerizing and forming a complement membrane attack complex. It is also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin. CD59 is a glycoprotein, and it is encoded by theCD59人类的基因。它是LU结构蛋白。此外,CD59属于LY6/UPAR/α-神经毒素蛋白家族。
CD59通过糖磷脂酰肌醇(GPI)锚固连接到宿主细胞。通常,当补体激活导致C5B678在宿主细胞上沉积时,CD59可以防止聚合和形成补体膜攻击复合物。CD59还可以向细胞发出信号以执行主动措施,例如endocytosisof the CD59-CD9 complex. Furthermore, themutations影响GPI锚的降低了CD59的表达,这导致一种称为阵发性夜间血红蛋白尿症的疾病。
What are the Similarities Between CD55 and CD59?
- CD55and CD59 are two proteins that regulate the complement system by inhibiting the formation of complement membrane attack complexes.
- 两者都是糖蛋白。
- 影响GPI锚的突变降低了CD55和CD59的表达,从而导致一种称为阵发性夜间血红蛋白尿的疾病。
- 它们对于调节宿主免疫反应非常重要。
What is the Difference Between CD55 and CD59?
CD55is a protein that regulates the complement system by inhibiting aggregation of C3 convertases of the classical and alternative pathways and forming complement membrane attack complexes, while CD59 is a protein that regulates the complement system by preventing C9 from polymerizing and forming complement membrane attack complex. Thus, this is the key difference between CD55 and CD59. Furthermore, CD55 is encoded by theCD55人类中的基因,而CD59由CD59人类的基因。
以下信息图显示了与表格形式的CD55和CD59之间的差异.
摘要 - CD55 vs CD59
CD55and CD59 are two glycoproteins. CD55 regulates the complement system by inhibiting aggregation of C3 convertases of the classical and alternative pathways and forming complement membrane attack complex. On the other hand, CD59 regulates the complement system by preventing C9 from polymerizing and forming a complement membrane attack complex. So, his is the key difference between CD55 and CD59.
Reference:
1.“”衰减加速因子”。概述|三英洁具ceDirect Topics.
2. “CD59”。概述|三英洁具ceDirect Topics.
Image Courtesy:
1.“”Protein CD55 PDB 1h03” By Emw – Own work(CC BY-SA 3.0)via Commons Wikimedia
2. “CD592j8b”(CC BY-SA 4.0)via Commons Wikimedia
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