关键区别 - 肌钙蛋白与肌球蛋白
在学习肌钙蛋白和肌动蛋白之间的差异之前,正确理解肌肉收缩和放松的机制很重要。肌肉纤维由肌原纤维。肌原纤维由在称为肉瘤的部分中排列的长蛋白组成,这些蛋白是条纹肌肉组织的基本构件。Saromere有两个组件,称为薄细丝,由肌动蛋白和肌球蛋白蛋白质分别。肌球蛋白和肌动蛋白的厚细丝在肌膜中彼此排列。这两种蛋白质在每个肌节中的相互作用导致肌膜缩短,这又导致肌肉收缩。在肌膜收缩期间,厚细丝中的肌球蛋白头与肌动蛋白在薄丝中结合,并将细丝朝向中心。肉瘤的末端将其拉近在一起,缩短肌肉纤维的长度。钙离子是肌膜收缩所必需的。当钙离子浓度升高时,肌肉收缩和低肌肉时,肌肉就会放松。肌钙蛋白和tropomyosin是两种蛋白质,可通过钙结合调节肌节收缩。当存在钙离子时,钙与肌钙蛋白结合并去除肌球蛋白。它暴露于肌动蛋白中的肌球蛋白结合位点。 When the muscle is relaxed, tropomyosin blocks the myosin binding sites in the actin filaments. The key difference between troponin and tropomyosin is that肌钙蛋白释放肌动蛋白丝的肌球蛋白结合位点尽管肌球蛋白阻止结合位点。
CONTENTS
1。概述和关键差异
2。什么是肌钙蛋白
3。什么是tropomyosin
4。肌钙蛋白和tropomyosin之间的相似之处
5。并排比较 - 表格形式的肌钙蛋白与tropomyosin
6。Summary
什么是肌钙蛋白?
As explained above, Troponin is a type of protein that regulates sarcomere contraction via calcium binding. Troponin is thus associated with actin filaments.
当钙离子和ATP存在,钙离子与肌钙蛋白结合。当钙离子与肌钙蛋白结合时,它会通过从肌动蛋白丝中去除肌动蛋白丝上的肌球蛋白结合位点在肌动蛋白丝上的暴露。因此,肌球蛋白(厚细丝)与肌动蛋白(薄细丝)结合,并将细丝朝向中心。它导致肉皮收缩并缩短其长度。
肌钙蛋白作为三种调节蛋白(肌钙蛋白C,肌钙蛋白I和肌钙蛋白T)的复合物存在。肌钙蛋白负责肌肉收缩。
什么是tropomyosin?
肌球蛋白is another type of regulatory protein associated with thin filaments of myofibrils. When the muscle is in a relaxed form, tropomyosins block the myosin binding sites on the actin filaments. Tropomyosins are positioned on the actin filaments in such a way that the binding of myosin heads to binding sites on the actin filaments is prevented. When the contact between myosin and actin is prevented, muscle contraction stops. However, when there are enough calcium ions and ATP, tropomyosin is able to roll away tropomyosin from the actin filaments. When tropomyosins are detached from the actin filaments, myosin binding sites are exposed and interaction between actin and myosin is facilitated. Myosin’s binding to actin causes cross bridge formation and contraction of the muscle.
tropomyosin是两条链α螺旋线圈线圈蛋白。肌动蛋白经常分为两组。肌肉真皮球蛋白同工型和非肌肉肌球蛋白同工型。
肌钙蛋白和肌动球蛋白之间有什么相似之处?
- 肌钙蛋白和原肌球蛋白是调控蛋白of muscle contraction.
- 肌钙蛋白和肌霉素附着在肌动蛋白丝上。
- Both are present in myofibrils.
肌钙蛋白和肌霉素有什么区别?
肌钙蛋白与肌球蛋白 |
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肌钙蛋白暴露于肌动蛋白丝中的肌球蛋白结合位点。 | 肌球蛋白覆盖肌球蛋白结合的肌动蛋白上的活性位点。 |
Muscle Movement | |
Troponin facilitates contraction. | 肌球蛋白可防止收缩,并使肌肉放松。 |
Summary – Troponin vs Tropomyosin
Troponin and tropomyosin are two regulatory proteins associated with actin filaments of myofibrils. Both are involved in the regulation of muscle cell contraction. Troponin causes the removal of tropomyosin from the actin filaments and exposure of myosin binding sites on actin filaments. Tropomyosins block myosin binding sites on actin filaments. Troponin facilitates sarcomere contraction while tropomyosin facilitates muscle relaxation. This is the difference between troponin and tropomyosin.
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References:
1。“Troponin.” Wikipedia. Wikimedia Foundation, 20 June 2017. Web.在这里可用。2017年7月8日。
2。“The Sliding Filament Model of Contraction.” Muscle Fiber Contraction and Relaxation. N.p., n.d. Web.在这里可用。2017年7月8日。
图片提供:
1. Jeff16的“肌动蛋白肌球蛋白” - 自己的工作(CC BY-SA 4.0)通过下议院维基梅迪亚
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