Thekey differencebetween trichloroacetic acid and trifluoroacetic acid is thattrichloroacetic acid is a colourless to white crystalline solid compound, whereas trifluoroacetic acid occurs as a colourless liquid.
Trichloroacetic acid and trifluoroacetic acid are organic acid compounds we can categorize ascarboxylic acids由于存在–COOH官能团。
内容
1.Overview and Key Difference
2.What is Trichloroacetic Acid
3.What is Trifluoroacetic Acid
4.Side by Side Comparison –Trichloroacetic Acid vs Trifluoroacetic Acid in Tabular Form
5.概括
What is Trichloroacetic Acid?
三氯乙酸是具有化学式（CL）的有机化合物3-c-c-ooh。It is also named as TCA acid, TCAA, or as trichloroethanoic acid. It is an analogue of醋酸; the three hydrogen atoms bonded directly to the carbon atom in acetic acid are replaced by three氯atoms in trichloroacetic acid molecule. There are salts and esters of trichloroacetic acid that are collectively named as trichloroacetates.
Figure 01: Chemical Structure of Trichloroacetic Acid
Furthermore, this substance occurs as a colourless to white crystalline solid compound. It also has a sharp, pungent odour. We can prepare this compound through the reaction between chlorine and acetic acid in the presence of a suitable catalyst. In addition to this, we can produce the same compound through the oxidation of trichloroacetaldehyde.
三氯乙酸有多种用途，包括用于沉淀大分子（例如DNA，RNA和蛋白质）的生物化学中的用途，用于化妆品治疗（例如化学果皮），作为用于疣化学的局部用药。
什么是三氟乙酸？
Trifluoroacetic acid is an organic compound having the chemical formula (F)3-c-c-ooh。它是一种有机氟化化合物，是乙酸的结构类似物，乙酰基组中所有三个氢原子都被氟原子取代。
Figure 02: Chemical Structure of Trifluoroacetic Acid
Moreover, this substance occurs as a colourless liquid having a pungent, vinegar-like odour. It is miscible with water. When considering the acidic strength, trifluoroacetic acid is a stronger acid than acetic acid due to the high electronegativity of fluorine atoms and the consequent electron-withdrawing nature of the trifluoromethyl group, which weakens the strength of the oxygen-hydrogen bond.
Industrially, we can prepare trifluoroacetic acid by the electrofluorination of acetyl chloride or acetic anhydride followed by the hydrolysis of the resulting product. However, this compound also occurs naturally in seawater but in trace amounts.
There are some important uses of trifluoroacetic acid. It is the precursor to many other fluorinated compounds such as trifluoroacetic anhydride. It is also useful as a reagent in organic synthesis reactions due to its properties such as volatility, solubility in organic solvents, acidic strength, etc. However, this substance is corrosive due to high acidity and is harmful when inhaled.
What is the Difference Between Trichloroacetic Acid and Trifluoroacetic Acid?
Trichloroacetic acid and trifluoroacetic acid are organic acid compounds we can categorize as carboxylic acids due to the presence of –COOH functional group. The key difference between trichloroacetic acid and trifluoroacetic acid is that trichloroacetic acid is a colourless to white crystalline solid compound, whereas trifluoroacetic acid occurs as a colourless liquid. Moreover, trichloroacetic is composed of chlorine, carbon, oxygen and hydrogen atoms while trifluoroacetic is composed of fluorine, carbon, oxygen and hydrogen atoms.
The below infographic summarizes the differences between trichloroacetic acid and trifluoroacetic acid in tabular for side by side comparison.
概括– Trichloroacetic Acid vs Trifluoroacetic Acid
三氯乙酸是具有化学式（CL）的有机化合物3-C-C-OOH, while trifluoroacetic acid is an organic compound having the chemical formula (F)3-c-c-ooh。The key difference between trichloroacetic acid and trifluoroacetic acid is that trichloroacetic acid is a colourless to white crystalline solid compound, whereas trifluoroacetic acid occurs as a colourless liquid.
Reference:
1. “Trifluoroacetic Acid.” ScienceDirect,Available here.
Image Courtesy:
1. “Trichloroacetic acid structure” By Yikrazuul (talk) – Own work (Public Domain) viaCommons Wikimedia
2. “Trifluoroacetic acid” By Yikrazuul (talk) – Own work (Public Domain) viaCommons Wikimedia
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