Difference Between Stem Cell Differentiation and Self Renewal

Thekey differencebetween stem cell differentiation and self renewal is the basis of the effect they create.While stem cell differentiation is the process in which normal stem cells likeembryonic stem cellsconvert into specialized cells with functional and structural properties, self renewal is the process of cell regeneration.

Stem cells are a group of cells that possess the ability to differentiate into different types of cells during their development. They show various development patterns on the basis of their cellular function and structure. Aging of cells is also an aspect that is looked upon, and self-renewal plays an important role in delaying the process of aging.

内容

1.Overview and Key Difference
2.What is Stem Cell Differentiation
3.什么是自我更新
4.Similarities Between Stem Cell Differentiation and Self Renewal
5.Side by Side Comparison – Stem Cell Differentiation vs Self Renewal in Tabular Form
6。概括

What is Stem Cell Differentiation?

干细胞分化是一个多步骤过程，正常细胞转换为具有特殊功能的专用细胞。增殖细胞通过改变细胞结构，适应性，代谢和细胞敏感性而进行专业化。遵循这些变化，细胞获得了特殊功能的能力。

The process of stem cell differentiation is mediated through the activity of酶，激素, cell signaling pathways. It is truly a genetically controlled process. Therefore, alteration of the genetic composition may lead to an abnormal cell differentiation pattern.

The type of stem cells can vary as全能，多能,multipotent, oligopotent and unipotent based on their ability to differentiate. Totipotent stem cells can differentiate into any type of cells. Pluripotent stem cells also have wide spectra of differentiation; however, it is limited. In contrast, multipotent stem cells can differentiate into a related group of cell types. Out of the different types of stem cells, the embryonic stem cells are of particular interest as they can differentiate into many different cell types upon proliferation.

什么是自我更新?

自我更新，细胞更新或细胞再生是指细胞在损伤或损失时再生的自然过程。细胞的自我更新能力基于细胞的类型不同。因此，他们的续签率也可能有所不同。细胞更新的主要过程是有丝分裂。它们在细胞分裂过程中保持染色体数，并产生与母细胞相同的子细胞。这允许精确的细胞自我更新。自我更新过程是一个受控过程，许多细胞信号传导机制有助于此过程。

在考虑干细胞时，自我更新是干细胞的分裂，以使更多的干细胞保持不变状态。因此，自我更新既具有多能力和组织再生潜力。

干细胞分化和自我更新之间有什么相似之处？

• Both processes are mediated by mitosis.
• Cell signaling is an important factor in determining the accuracy of both processes.
• Genetics play an important role in regulating both differentiation and renewal.
• 突变可能导致异常of both phenomena.
• In both phenomena, the rate of occurrence may vary with the type of cells.
• Differentiation and self renewal take place following cell proliferation.

干细胞分化和自我更新有什么区别？

干细胞分化和自我更新是两个受严格调节的过程。两者都发生在干细胞中，并根据它们在细胞发育过程中带来的影响而分化。干细胞分化是指将未分化的细胞区分为指定功能的专用细胞的过程。同时，自我更新是指细胞分裂以制造更多细胞。因此，这是干细胞分化和自我更新之间的关键区别。

概括– Stem Cell Differentiation vs Self Renewal

Stem cell differentiation and self renewal are two important phenomena that take place during the development of a cell. Stem cells are non-differentiated cells. However, following various signaling mechanisms, stem cells convert into differentiated cell types. Following differentiation, a particular cell can engage in its functionality. Self renewal of a cell takes place as a regeneration mechanism to delay the aging process. Both are thoroughly regulated by signaling mechanisms and genetic factors. Therefore, abnormality of cellular activities could be due to the alterations in cell differentiation and self renewal processes. This is the summary of stem cell differentiation and self renewal.

Reference:

1.“ 3.6细胞分化。”解剖学和生理学，OpenStax，2013年3月6日，Available here.
2.席尔瓦，哈罗多。“衰老和干细胞更新。”Stembook [Internet]。，美国国家医学图书馆，2008年7月15日，Available here.

Image Courtesy:

1. “Final stem cell differentiation (1)” By Haileyfournier – Own work(CC BY-SA 4.0)viaCommons Wikimedia