Thekey differencebetween partition coefficient and distribution coefficient is that thepartition coefficient refers to the concentration of un-ionized chemical species of a compound whereas the distribution coefficient refers to the concentration of both ionized and un-ionized chemical species of a compound.
The two terms partition coefficient and distribution coefficient are usually used interchangeably because both these terms nearly express the same idea about the distribution of a chemical species between two mediums. However, these terms differ from each other depending on the chemical species we are considering in the calculation.
内容
1.Overview and Key Difference
2.What is Partition Coefficient
3.What is Distribution Coefficient
4.Side by Side Comparison – Partition Coefficient vs Distribution Coefficient in Tabular Form
5.概括
What is Partition Coefficient?
分区系数是在两个不混溶的阶段的混合物中的非电离物种的浓度之比。我们通常将这种现象表示为“ P”。这两个不同的阶段应相互平衡,以确定该两相系统的分区系数。该比率代表了solubility该混合物中的每个非电离物种。
Generally, the two immiscible phases we consider here are solvents. Mostly, it is a water-organic solvent system. Therefore, we often considerhydrophilic–hydrophobicsystems when determining the partition coefficient. There, the partition coefficient is a measure of thelipophilicityor the hydrophobicity of the solute that we are interested at. This phenomenon is very important in determining drug distribution throughout our body.
什么是分配系数?
Distribution coefficient is the ratio of the concentration of both ionized and un-ionized species of a compound in a mixture of two immiscible phases. We can denote this phenomenon as “D”. Here, one of the two immiscible phases is essentially water or an aqueous solution. The other phase is usually a hydrophobic phase which is immiscible with water (or any other aqueous phase we use here). Usually, we give this value as a logarithmic value because it is a very small value.
What is the Difference Between Partition Coefficient and Distribution Coefficient?
尽管我们可以互换使用术语分区系数和分布系数,但它们彼此不同。分区系数和分布系数之间的关键区别在于,术语分配系数是指化合物的未电离化学物种的浓度,而该术语分布系数是指一个化合物的电离化学物质和未电离化学物质的浓度。
When considering the two immiscible phases, in determining partition coefficient, we mostly use a combination of water and a hydrophobic phase while in determining the distribution coefficient we essentially use an aqueous phase with another suitable phase.
下面的表总结了差异een partition coefficient and distribution coefficient.
概括– Partition Coefficient vs Distribution Coefficient
尽管我们可以互换使用术语分区系数和分布系数,但它们彼此不同。这些术语彼此不同,具体取决于我们考虑的每个计算的化学物种。分区系数和分布系数之间的关键区别在于,术语分配系数是指化合物的未电离化学物种的浓度,而该术语分布系数是指一个化合物的电离化学物质和未电离化学物质的浓度。
Reference:
1.“Partition Coefficient.”Wikipedia, Wikimedia Foundation, 23 Sept. 2019,Available here.
2. “Partition Coefficient.” ScienceDirect Topics,Available here.
3. Oscarson, Dennis W., and Harold B. Hume. “Effect of the Solid: Liquid Ratio on the Sorption of
Sr2 and Cs on Bentonite.” Adsorption of Metals by Geomedia, 1998, pp. 277–289.,
doi:10.1016/b978-012384245-9/50013-x.
Image Courtesy:
1. “Partitioning coefficient (Kd)” By Perdula – Own work(CC BY-SA 3.0)viaCommons Wikimedia
发表评论